DEPRENYL COMPOUNDS TO TREAT VIRAL INFECTIONS AND REDUCE TISSUE DAMAGE ASSOCIATED THEREWITH
First Claim
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1. A method of treating a viral infection, comprising administering to a subject in need thereof a therapeutically effective amount of a deprenyl compound, such that treatment of the viral infection occurs.
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Abstract
Methods for treating viral infections are disclosed. The methods of the invention are useful for inhibiting viral infection in a subject and for preventing reducing tissue damage associated with viral infections. The method can include the step of administering to a subject in need thereof a therapeutically effective amount of a deprenyl compound, such that treatment of a viral infection occurs.
12 Citations
23 Claims
- 1. A method of treating a viral infection, comprising administering to a subject in need thereof a therapeutically effective amount of a deprenyl compound, such that treatment of the viral infection occurs.
- 9. A method of inhibiting replication of a virus in a virus-infected cell, comprising contacting the virus-infected cell with an effective amount of a deprenyl compound, such that the affinity of GAPDH for viral RNA is decreased and viral replication in the virus-infected cell is inhibited.
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14. A method for decreasing the affinity of GAPDH for viral RNA, the method comprising contacting GAPDH with a deprenyl compound, such that the affinity of GAPDH for viral RNA is decreased.
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18. A method for inhibiting replication of a virus in a virus-infected cell, comprising inhibiting colocalization of GAPDH with PML such that replication of the virus in the virus-infected cell is inhibited.
- 20. A method for inhibiting tissue damage due to viral infection, comprising administering to a subject in need thereof an effective amount of a deprenyl compound such that prevention of tissue damage due to viral infection occurs.
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