Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
First Claim
1. A method of monitoring and evaluating the status of a tumor undergoing treatment, comprising the steps of:
- (a) monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment with an in situ sensor unit;
(b) transmitting data associated with the at least one monitored physiological parameter from the in situ positioned sensor unit to a receiver located external to the subject;
(c) analyzing the transmitted data to determine a condition of the tumor;
(d) repeating steps (a), (b), and (c) periodically at a plurality of sequential points in time; and
(e) evaluating a tumor treatment strategy.
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Accused Products
Abstract
Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor'"'"'s condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.
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Citations
68 Claims
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1. A method of monitoring and evaluating the status of a tumor undergoing treatment, comprising the steps of:
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(a) monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment with an in situ sensor unit;
(b) transmitting data associated with the at least one monitored physiological parameter from the in situ positioned sensor unit to a receiver located external to the subject;
(c) analyzing the transmitted data to determine a condition of the tumor;
(d) repeating steps (a), (b), and (c) periodically at a plurality of sequential points in time; and
(e) evaluating a tumor treatment strategy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A tumor monitoring system for evaluating the efficacy of radiation or drug treatment and/or identifying enhanced active treatment windows, comprising:
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at least one sensor unit comprising a plurality of sensor elements and associated sensor electronics, wherein a plurality of said plurality of sensor elements are configured for in vivo in situ contact with a cancerous tumor in a subject undergoing treatment, and wherein said sensor elements are configured to detect a plurality of different physiological parameters associated with the tumor and wirelessly transmit data associated with the detected parameters; and
a remote receiver in wireless communication with said at least one sensor, said receiver configured to receive the transmitted data, wherein said receiver is spatially separate from said at least one sensor and positioned external to the subject, wherein said at least one sensor unit has an implanted service life of at least about 6-10 weeks. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 55, 56, 57, 58, 59, 60, 61, 62)
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54. A computer program product for monitoring and analyzing the condition of a tumor undergoing treatment, the computer program product comprising:
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a computer readable storage medium having computer readable program code means embodied in said medium, said computer-readable program code means comprising;
computer readable program code means for commencing a first wireless data transmission from an in situ sensor with at least one sensor element, the at least one sensor element positioned in a subject proximate to a tumor undergoing treatment to monitor at least one physiological or biological parameter of the tumor, the data transmission including data corresponding to the output of the at least one sensor element;
computer readable program code means for commencing a second wireless data transmission the in situ sensor temporally separate from the first wireless data transmission; and
computer readable program code means for tracking variation between the first and second data transmissions to provide a dynamic behavioral model of the tumor'"'"'s response to the treatment.
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63. An implantable biocompatible sensor unit, comprising:
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an in situ sensor body having at least one sensor element configured for in vivo contact of a tumor and to output data responsive to at least one sensed condition, and a transmitter coil and associated electronic components configured for wireless transmittal of the sensor output data to a spatially remote receiver, said sensor body being encapsulated in a biocompatible material, and wherein said sensor element is configured on said sensor body with a biocompatible active sensor surface, wherein said sensor unit is inductively powered, and wherein said sensor body is configured as a substantially cylindrically shaped body having opposing first and second ends, and wherein said sensor is sized and configured to be injectable via a large bore canula into a subject.
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64. An implantable biocompatible sensor unit, comprising:
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a primary sensor body portion with operating electronics positioned thereon; and
a plurality of arms extending outwardly therefrom, each of said arms having distal portions containing at least one sensor element thereon and having at least one signal path between said operating electronics in said first body portion to each of said sensor elements in each of said arms. - View Dependent Claims (65, 66, 67)
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68. An implantable biocompatible sensor, comprising:
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an implantable satellite sensor; and
an associated plurality of injectable discrete dependent sensors, wherein each of said discrete dependent sensors have at least one sensor element thereon, and wherein said plurality of discrete dependent sensors are in wireless communication with said satellite sensor, and wherein said satellite sensor is in wireless communication with an externally located receiver.
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Specification