Compositions and methods for cleaning contact lenses

• US 20020141899A1
• Filed: 09/26/2001
• Published: 10/03/2002
• Est. Priority Date: 09/28/2000
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Tsao, Fu-Pao
• Granted Patent: US 7,022,654 B2
• Time in Patent Office: Days
• US Class Current: 422/28
• CPC Class Codes: A61L 12/124 Hydrogen peroxide; Peroxy compounds
• CPC Class Codes: A61L 12/128 neutralised with catalysts
• CPC Class Codes: C11D 1/008 Polymeric surface-active agents
• CPC Class Codes: C11D 3/0026 Low foaming or foam regulating compositions
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/3947 Liquid compositions

Abstract

A composition for disinfecting a contact lens comprising an effective disinfecting amount of hydrogen peroxide and a surfactant comprising a copolymer of hydrophobe and hydrophile blocks the structure:

HO-(hydrophobe)_x-(hydrophile)_y-(hydrophobe)_x-H

or

HO-(hydrophile)_y-(hydrophobe)_x-(hydrophile)_y-H

where x and y are integers reflecting the respective hydrophile and hydrophobe blocks of said copolymer; and the hydrophile component of the block copolymer constitutes less than 50 weight percent of the block copolymer. The block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53; 0.1%, at 50° C.) of less than 1 mm.

Claims

1. A composition for disinfecting a contact lens comprising an effective disinfecting amount of hydrogen peroxide and a surfactant comprising a low-foaming or non-foaming copolymer of hydrophobe and hydrophile blocks of the structure:

HO-(hydrophobe)_x-(hydrophile)_y-(hydrophobe)_x-HorHO-(hydrophile)_y-(hydrophobe)_x-(hydrophile)_y-H

wherein x and y are integers reflecting the respective hydrophile and hydrophobe blocks of said copolymer; and

the hydrophile component of the block copolymer constitutes less than 50 weight percent of the block copolymer.

2. A composition for disinfecting a contact lens as claimed in claim 1, wherein said hydrophile is polyoxyethylene.

3. A composition for disinfecting a contact lens as claimed in claim 2, wherein said hydrophobe is polyoxypropylene.

4. A composition for disinfecting a contact lens as claimed in claim 3, wherein said block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53;

0.1%, at 50°

C.) of less than 1 mm.

5. A composition for disinfecting a contact lens as claimed in claim 4, wherein said block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53;

0.1%, at 50°

C.) of about 0 mm.

6. A composition for disinfecting a contact lens as claimed in claim 1, wherein the hydrophile constitutes from about 10 to 50 weight percent of the block copolymer.

7. A composition for disinfecting a contact lens as claimed in claim 6, wherein the hydrophile constitutes about 40 weight percent of the block copolymer.

8. A composition for disinfecting a contact lens as claimed in claim 1, wherein the molecular weight of the hydrophobe block is from about 1200 and about 3100.

9. A composition for disinfecting a contact lens as claimed in claim 8, wherein the molecular weight of the hydrophobe is from about 1000 and about 2500.

10. A composition for disinfecting a contact lens as claimed in claim 9, wherein the molecular weight of the hydrophobe is approximately 1700.

11. A composition for disinfecting a contact lens as claimed in claim 1, wherein said surfactant is present in the range of about 0.005% to about 0.8%.

12. A composition for disinfecting a contact lens as claimed in claim 11, wherein said surfactant is present in the range of about 0.01% to about 0.5%

13. A composition for disinfecting a contact lens as claimed in claim 12, wherein said surfactant is less than 0.1% by weight of the solution.

15. A composition for disinfecting a contact lens as claimed in claim 14, wherein said block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53;

0.1%, at 50°

C.) of about 0 mm.

16. A composition for disinfecting a contact lens as claimed in claim 15, wherein the polyoxyethylene component of the block copolymer constitutes about 40 weight percent of the block copolymer.

17. A composition for disinfecting a contact lens as claimed in claim 14, wherein the molecular weight of the polyoxypropylene block is from about 1200 and about 3100.

18. A composition for disinfecting a contact lens as claimed in claim 17, wherein the molecular weight of the polyoxypropylene block is approximately 1700.

19. A composition for disinfecting a contact lens as claimed in claim 14, wherein said surfactant is present in the range of about 0.005% to about 0.8%.

20. A composition for disinfecting a contact lens as claimed in claim 21, wherein said surfactant is less than 0.1% by weight of the solution.

21. A composition for disinfecting a contact lens as claimed in claim 14, wherein hydrogen peroxide is present in a concentration of about 0.5% to about 6% by weight.

22. A composition for disinfecting a contact lens as claimed in claim 21, wherein hydrogen peroxide is present in a concentration of 2% to 6% by weight.

23. A composition for disinfecting a contact lens as claimed in claim 21, further comprising a hydrogen peroxide stabilizer;

wherein said stabilizer comprises a diphosphonic acid alkanol.

24. A composition for disinfecting a contact lens as claimed in claim 23, wherein said stabilizer comprises diethylene triamine penta-(methylenephosphonic acid) or a occularly compatible salt thereof;

wherein said stabilizer is about 0.006 and about 0.02% by weight of the composition.

25. A composition for disinfecting a contact lens as claimed in claim 22, further comprising a buffer to maintain said composition at a pH of about 4 to about 9.

26. A composition for disinfecting a contact lens as claimed in claim 25, wherein said buffer is selected from the group consisting of basic acetates, phosphates, borates, nitrates, sulfates, tartrates, lactates, carbonates, bicarbonates, and mixtures thereof;

wherein said buffer is present in the range of 0.001% to 2%.

27. A composition for disinfecting a contact lens as claimed in claim 26, wherein said phosphate buffer is selected from the group consisting of monobasic phosphates, dibasic phosphates, and mixtures thereof;

wherein said phosphate buffer is present in the range of from about 0.05% to about 0.30%.

28. A composition for disinfecting a contact lens as claimed in claim 27, further comprising a tonicity component to provide the solution with a tonicity of from 50 to 400 mosmol/kg;

wherein said tonicity component is selected from the group consisting of water soluble salts compatible with ocular tissue.

30. A composition for disinfecting a contact lens as claimed in claim 29, wherein said block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53;

0.1%, at 50°

C.) of about 0 mm.

31. A composition for disinfecting a contact lens as claimed in claim 30, wherein the polyoxyethylene component of the block copolymer constitutes less than 50 weight percent of the block copolymer.

32. A composition for disinfecting a contact lens as claimed in claim 30, wherein said stabilizer comprises diethylene triamine penta-(methylenephosphonic acid) or a occularly compatible salt thereof and is present in the composition in an amount between about 0.001 and about 0.03% by weight of the solution.

33. A composition for disinfecting a contact lens as claimed in claim 30, wherein said buffer is selected from the group consisting of sodium dibasic phosphate (Na₂HPO₄), sodium monobasic phosphate (NaH₂PO₄), potassium monobasic phosphate (KH₂PO₄), and mixtures thereof;

and said phosphate buffer is present in the range of from about 0.05% to about 0.30%.

34. A composition for disinfecting a contact lens as claimed in claim 30, wherein said tonicity component is sodium chloride and provides said solution with a tonicity of from 250 to 350 mosmol/kg.

35. A composition for disinfecting a contact lens as claimed in claim 29, comprising from 2 to 6% hydrogen peroxide;

and between 0.01% and 0.10% polyoxyethylene/polyoxypropylene block copolymer;

wherein the polyoxyethylene component of the block copolymer constitutes about 40 weight percent of the block copolymer; and

wherein the molecular weight of the polyoxypropylene block of the copolymer is approximately 1700.

37. A method of disinfecting a contact lens as claimed in claim 36, wherein said step of neutralizing comprises contacting said solution with a metal catalyst.

38. A method of disinfecting a contact lens as claimed in claim 37, wherein the lens is ready for insertion into the eye without a step of manually rubbing the lens.

14. A composition for disinfecting a contact lens comprising an aqueous solution of an effective disinfecting amount of hydrogen peroxide and a polyoxyethylene/polyoxypropylene block copolymer having the structure:

29. A composition for disinfecting a contact lens comprising an aqueous solution of:

hydrogen peroxide;

a buffer compatible with ocular tissue;

a hydrogen peroxide stabilizer comprising a diphosphonic acid alkanol;

a tonicity component; and

polyoxyethylene/polyoxypropylene block copolymer having the structure;

 

wherein x and y are integers reflecting the respective polyethylene oxide and polypropylene oxide blocks of said copolymer.

36. A method of disinfecting a contact lens comprising the steps of:

(a) contacting a contact lens with an aqueous solution of an effective disinfecting amount of hydrogen peroxide and a polyoxyethylene/polyoxypropylene block copolymer having the structure;

wherein x and y are integers reflecting the respective polyethylene oxide and polypropylene oxide blocks of said copolymer; and

the polyoxyethylene component of the block copolymer constitutes less than 50 weight percent of the block copolymer;

wherein said block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53;

0.1%, at 50°

C.) of less than 1 mm; and

(b) neutralizing said hydrogen peroxide by catalytic decomposition.