Spatiotemporal and geometric optimization of sensor arrays for detecting analytes fluids
First Claim
1. A flow-through fluid analysis system for detecting an analyte in a fluid flow, comprising:
- a sensor array having a first face and a second face, the sensor array including one or more first sensors and one or more fluid channels extending from the first face to the second face, at least one of the first sensors being located at a first position in the sensor array in contact with the first face of the sensor array, the one or more first sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow;
a fluid flow system for introducing a fluid flow containing an analyte to the sensor array, such that upon introduction of a fluid flow to the sensor array a pressure differential is created between the first and second faces of the sensor array; and
a processor configured to receive the response generated by the one or more first sensors and to process the response to detect at least one analyte in a fluid flow.
6 Assignments
0 Petitions
Accused Products
Abstract
Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.
198 Citations
73 Claims
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1. A flow-through fluid analysis system for detecting an analyte in a fluid flow, comprising:
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a sensor array having a first face and a second face, the sensor array including one or more first sensors and one or more fluid channels extending from the first face to the second face, at least one of the first sensors being located at a first position in the sensor array in contact with the first face of the sensor array, the one or more first sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow;
a fluid flow system for introducing a fluid flow containing an analyte to the sensor array, such that upon introduction of a fluid flow to the sensor array a pressure differential is created between the first and second faces of the sensor array; and
a processor configured to receive the response generated by the one or more first sensors and to process the response to detect at least one analyte in a fluid flow. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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27. A method of detecting an analyte in a fluid flow, comprising:
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providing a sensor array having a first face and a second face, the sensor array including one or more first sensors and one or more fluid channels extending from the first face to the second face, at least one of the first sensors being located at a first position in the sensor array in contact with the first face of the sensor array, the one or more first sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow;
exposing the sensor array to a fluid flow including an analyte under conditions sufficient to create a pressure differential between the first and second faces of the sensor array;
measuring a response for the one or more first sensors; and
detecting the presence of the analyte in the fluid based on the measured response.
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53. A sensor array for detecting an analyte in a fluid, comprising:
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one or more substrates, each substrate having a first surface;
one or more sensors in contact with the substrates, the sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid, each sensor having a sensor volume, the sensor volume for at least one of the sensors being substantially optimized to cause the first sensor to generate an optimized response upon exposure of the sensor array to at least one target analyte. - View Dependent Claims (54, 55, 56, 57, 59, 60, 61, 62, 63, 64, 65)
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58. A sensor array for detecting an analyte in a fluid flow, comprising:
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a substrate having a first surface and a second surface;
one or more sensors in contact with the first surface, the one or more sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow; and
one or more fluid channels extending from the first surface to the second surface.
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66. A sensor array for detecting an analyte in a fluid flow, the sensor array having a first face and a second face, the sensor array comprising:
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one or more substrates, each substrate forming a plate having a length, a width, and a depth, such that the length and the width in combination define a pair of substrate faces and the width and the depth in combination define a first substrate edge and a second substrate edge, the first substrate edge for each of the substrates being aligned with the first face of the array;
a plurality of sensors configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow, the sensors including one or more first sensors sensors, each of the first sensors being located along one of the first substrate edges, the sensors also including one or more second sensors, each of the second sensors being located along one of the substrate faces; and
one or more fluid channels extending along one or more of the substrate faces from the first face of the array to the second face of the array. - View Dependent Claims (67, 68, 69, 70, 71)
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72. A method of fabricating a sensor array for detecting an analyte in a fluid, comprising:
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providing a substrate having a surface and a sampling headspace proximate to the surface;
identifying a sampling headspace volume Vl for at least a portion of the sampling headspace, and a partition coefficient K of at least one target analyte in a sensing material;
calculating a sensor volume based on the sampling headspace volume and the partition coefficient; and
fabricating a sensor on the surface proximate to the at least a portion of the sampling headspace, the sensor including an amount of the sensing material derived from the calculated sensor volume. - View Dependent Claims (73)
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Specification