Method to incorporate N-(4-hydroxyphenyl) retinamide in liposomes
First Claim
1. A method of preparing a pharmaceutical retinoid composition, comprising the step of admixing at least one retinoid or a derivative thereof with dimyristoyl phosphatidylcholine, soybean oil, tertiarybutyl alcohol and water, wherein said admixing produces a mixture comprising liposomes in combination with the at least one retinoid or derivative thereof.
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Abstract
Disclosed herein are simple and unique methods of methods of preparing liposomal compositions of N-(4-hydroxyphenyl) retinamide (4HPR) and/or other retinoids. Also disclosed are liposomal 4HPR compositions prepared by such methods, and use of such compositions in the treatment of diseases, such as breast cancer. This invention further provides methods for improving the efficacy of N-(4-hydroxyphenyl) retinamide (4HPR) as a chemopreventive agent in the presence of agents that potentiates its ability increase the expression of inducible nitric oxide synthase (iNOS, and NO production in cells.
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Citations
130 Claims
- 1. A method of preparing a pharmaceutical retinoid composition, comprising the step of admixing at least one retinoid or a derivative thereof with dimyristoyl phosphatidylcholine, soybean oil, tertiarybutyl alcohol and water, wherein said admixing produces a mixture comprising liposomes in combination with the at least one retinoid or derivative thereof.
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42. A method of preparing a pharmaceutical retinoid composition, comprising the step of admixing N-(4-hydroxyphenyl) retinamide or a derivative thereof with dimyristoyl phosphatidylcholine, soybean oil, tertiarybutyl alcohol and water, wherein said admixing produces a mixture comprising liposomes in combination with the N-(4-hydroxyphenyl) retinamide or a derivative thereof.
- 43. A pharmaceutical retinoid composition comprising N-(4-hydroxyphenyl) retinamide, or a derivative thereof, encapsulated in a lipid material, wherein said lipid material comprises dimyristoyl phosphatidylcholine and soybean oil.
- 54. A method of treating a subject having cancer, comprising administering to said individual a therapeutically effective amount of a composition comprising N-(4-hydroxyphenyl) retamide, or a derivative thereof, encapsulated in a lipid material, wherein said lipid material comprises dimyristoyl phosphatidylcholine and soybean oil.
- 61. A method for increasing growth inhibitory effects of fenretinide on a cell comprising providing to a cell, in combination with fenretinide, one or more agents that increases the level of nitric oxide (NO) in said cell.
- 91. A method for treating cancer in a subject comprising providing to said subject, in combination, fenretinide and one or more agents that increases the level of nitric oxide (NO) in cancer cells in said subject.
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120. A composition of matter comprising fenretinide and an agent that increases the level of nitric oxide (NO) in a cell.
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129. A kit comprising fenretinide and at an agent that increases the level of nitric oxide (NO) in a cell.
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130. A method for inhibiting metastasis in a subject having cancer comprising providing to said subject, in combination, fenretinide and one or more agents that increases the level of nitric oxide (NO) in cancer cells in said subject.
Specification