Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused skeletal muscle tissue
First Claim
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1. A method for amelioration of organ tissue injury caused by reperfusion of blood flow following a period of ischemia, which comprises:
- administering to an individual in need of such treatment an effective amount of a composition which includes a compound which binds to a receptor for glucagon-like peptide-1, in a pharmaceutical carrier.
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Abstract
Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like peptide-1. The invention relates to both the method and compositions for such treatment.
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Citations
23 Claims
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1. A method for amelioration of organ tissue injury caused by reperfusion of blood flow following a period of ischemia, which comprises:
administering to an individual in need of such treatment an effective amount of a composition which includes a compound which binds to a receptor for glucagon-like peptide-1, in a pharmaceutical carrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22)
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14. The method of metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue, said method comprising:
administering to an individual in need of such treatment an effective amount of a composition comprising GLP-1 in a pharmaceutical carrier.
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23. A composition for use in metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue, comprising:
an effective amount of GLP-1 in combination with a pharmaceutically effective carrier.
Specification