Treatment of lipid pool

• US 20020147480A1
• Filed: 04/04/2001
• Published: 10/10/2002
• Est. Priority Date: 04/04/2001
• Status: Abandoned Application

• Current Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Mamayek, Donald S.
• Application Number:
  US09/826,762
• Publication Number:
  US 20020147480A1
• Time in Patent Office: Days
• US Class Current: 607/105
• CPC Class Codes: A61B 18/08 by means of electrically-heated probes
• CPC Class Codes: A61B 2017/00101 using an array of thermosensors
• CPC Class Codes: A61B 2017/22002 preventing restenosis

Abstract

A method and apparatus for solidifying inflamed and unstable plaque on the interior of a blood vessel including inserting a catheter assembly into a human blood vessel while the assembly is in a first, collapsed configuration, advancing the catheter assembly through the blood vessel, stopping at predetermined intervals and expanding the catheter assembly to a second, expanded configuration such that a plurality of temperature detectors contact the interior wall of the blood vessel. The areas of increased temperature are indicative of inflamed and unstable plaque, which is to be stabilized using at least one multi-temperature device, such as a Peltier device, to solidify the plaque and reduce the possibility of a myocardial infarction.

Claims

1. A method of solidifying plaque on the interior of a blood vessel comprising the steps of:

inserting a catheter assembly having an expandable portion into the blood vessel while the expandable portion is in a collapsed configuration;

advancing the assembly in the blood vessel;

stopping at a plurality of predetermined locations along the blood vessel and expanding the expandable portion to an expanded configuration such that a plurality of temperature detectors contact the interior wall of the blood vessel;

sensing variation in blood vessel temperature at the plurality of predetermined locations along the interior wall of the blood vessel; and

applying thermal energy to, or removing thermal energy from, areas of increased temperature to reduce the possibility of leakage of the plaque into the blood vessel.

2. The method of claim 1 wherein the step of applying or removing thermal energy involves the use of at least one multi-temperature device having a hot side and a cold side and being powered by an electrical current having a polarity.

3. The method of claim 2 wherein the catheter assembly further includes a therapy plate positioned in between the at least one multi-temperature device and the interior of the blood vessel wall;

the therapy plate having a tissue-contacting surface adapted to abut the interior of the blood vessel wall.

4. The method of claim 3 wherein the step of sensing blood vessel wall temperature variation further includes using temperature sensors located on the tissue-contacting surface of the therapy plate to sense variations in blood vessel tissue temperature.

5. The method of claim 4 further including the step of detecting the temperature of the therapy plate by using additional sensors imbedded within the therapy plate.

6. The method of claim 4 wherein the temperature sensors include thermocouples, thermistors or the like.

7. The method of claim 2 further including the step of reversing the polarity of the electrical current to change the hot side to the cold side and the cold side to the hot side.

8. The method of claim 2 further including the step of removing additional, undesired energy caused by the at least one multi-temperature device by using a heat exchanger as a heat sink.

9. The method of claim 8 wherein the step of removing undesired energy includes circulating fluid through an aperture in the heat exchanger.

10. The method of claim 2 wherein the at least one multi-temperature device includes a plurality of Peltier devices stacked one on top of another to increase the overall energy differential.

11. The method of claim 8 wherein the step of removing undesired energy includes using the blood circulating through an aperture in the heat exchanger to carry away the additional, undesired energy caused by the multi-temperature device.

12. The method of claim 8 wherein the heat exchanger includes an aperture lined with internal starburst fins.

13. The method of claim 8 wherein the thermal exchanger includes a serrated blood-contacting plate having a plurality of recesses.

14. The method of claim 1 further including the step of removing the solidified plaque resultant from the procedure.

15. The method of claim 14 wherein the solidified plaque is removed using atherectomy.

16. The method of claim 1 wherein the catheter assembly includes an expander, a heat exchanger, a therapy plate and at least one Peltier device.

17. The method of claim 16 wherein the expander is a balloon adapted to be inflated.

18. The method of claim 16 wherein the at least one Peltier device includes a plurality of Peltier devices stacked one on top of another to increase the overall energy differential.

19. The method of claim 16 further including a temperature control to monitor the temperature of the therapy plate.

20. The method of claim 16 further including a control box having a readout for artery wall temperature and therapy plate temperature.

21. The method of claim 2 wherein the multi-temperature device is a Peltier device.

22. An apparatus for solidifying plaque on the interior wall of a blood vessel comprising:

a catheter assembly for insertion into and advancement through a blood vessel, wherein the catheter assembly is to be stopped at predetermined intervals along the blood vessel; and

at least one multi-temperature device having a hot side and a cold side for solidifying plaque on the interior wall of the blood vessel.

23. The apparatus of claim 22 further including a plurality of temperature detectors for contacting the interior wall of the blood vessel and identifying areas of increased temperature indicative of inflamed and/or unstable plaque.

24. The apparatus of claim 22 wherein the catheter assembly is in a collapsed configuration during insertion and advancement through the blood vessel.

25. The apparatus of claim 24 wherein the catheter assembly is in an expanded configuration during solidification of the plaque.

26. The apparatus of claim 25 wherein the at least one multi-temperature device is powered by an electrical current having a polarity.

27. The apparatus of claim 22 wherein the catheter assembly includes a therapy plate positioned in between the at least one multi-temperature device and the interior of the blood vessel wall;

the therapy plate having a tissue-contacting surface adapted to abut the interior of the vessel wall.

28. The apparatus of claim 27 further including temperature sensors located on the tissue-contacting surface of the therapy plate for sensing variations in blood vessel tissue temperature.

29. The apparatus of claim 28 further including additional sensors imbedded within the therapy plate for detecting the temperature of the therapy plate.

30. The apparatus of claim 28 wherein the temperature sensors are thermocouples or thermistors.

31. The apparatus of claim 26 wherein the polarity of the electrical current can be reversed to change the hot side to the cold side and/or vice-versa.

32. The apparatus of claim 22 wherein the catheter assembly includes a heat exchanger for removing additional, undesired energy caused by the at least one multi-temperature device.

33. The apparatus of claim 32 wherein the heat exchanger has an aperture extending the length of the heat exchanger for the passage of blood.

34. The apparatus of claim 33 wherein blood is used to carry away the additional, undesired energy caused by the at least one multi-temperature device.

35. The apparatus of claim 33 wherein the aperture is lined with internal starburst fins.

36. The apparatus of claim 32 wherein the heat exchanger includes a serrated blood-contacting plate having a plurality of recesses.

37. The apparatus of claim 22 wherein the solidified plaque resultant from the procedure is to be removed using atherectomy.

38. The apparatus of claim 22 wherein the catheter assembly includes an expander, a heat exchanger, a therapy plate and at least one multi-temperature device.

39. The apparatus of claim 38 wherein the expander is an elastic balloon adapted to be inflated with a fluid.

40. The apparatus of claim 38 wherein the at least one multi-temperature device includes a plurality of multi-temperature devices stacked one on top of another to increase the overall energy differential.

41. The apparatus of claim 38 further including a temperature control to monitor the temperature of the therapy plate.

42. The apparatus of claim 38 further including a control box having a readout for artery wall temperature and therapy plate temperature.

43. The apparatus of claim 22 wherein the catheter assembly includes a catheter having an electrode on its distal tip.

44. The apparatus of claim 43 wherein the at least one multi-temperature device comprises a Peltier diode for cooling and heating the electrode.

45. The apparatus of claim 44 further including a heat exchanger.

46. The apparatus of claim 22 wherein the multi-temperature device includes a Peltier device.

47. The apparatus of claim 40 wherein the multi-temperature devices include Peltier devices.

49. The method of claim 48 wherein the step of applying or removing thermal energy involves the use of at least one Peltier device having a hot side and a cold side and being powered by an electrical current having a polarity.

50. The method of claim 49 wherein the catheter assembly further includes a therapy plate positioned in between the at least one Peltier device and the interior of the blood vessel wall;

the therapy plate having a tissue-contacting surface adapted to abut the interior of the blood vessel wall.

51. The method of claim 50 wherein the step of sensing blood vessel temperature variation further includes using temperature sensors located on the tissue-contacting surface of the therapy plate to sense variations in blood vessel tissue temperature.

52. The method of claim 51 further including the step of detecting the temperature of the therapy plate by using additional sensors imbedded within the therapy plate.

53. The method of claim 51 wherein the temperature sensors include thermocouples or thermistors.

54. The method of claim 49 further including the step of reversing the polarity of the electrical current to change the hot side to the cold side and the cold side to the hot side.

55. The method of claim 49 further including the step of removing additional, undesired energy caused by the at least one Peltier device by using a heat exchanger as a heat sink.

56. The method of claim 55 wherein the step of removing undesired energy includes circulating fluid through an aperture in the heat exchanger.

57. The method of claim 49 wherein the at least one Peltier device includes a plurality of Peltier devices stacked one on top of another to increase the overall energy differential.

58. The method of claim 55 wherein the step of removing undesired energy includes using the blood circulating through an aperture in the heat exchanger to carry away the additional, undesired energy caused by the Peltier device.

59. The method of claim 49 wherein the heat exchanger includes an aperture lined with internal starburst fins.

60. The method of claim 49 wherein the thermal exchanger includes a serrated blood-contacting plate having a plurality of recesses.

61. The method of claim 48 further including the step of removing the solidified plaque resultant from the procedure.

62. The method of claim 61 wherein the solidified plaque is removed using atherectomy.

63. The method of claim 48 wherein the catheter assembly includes an expander, a heat exchanger, a therapy plate and at least one Peltier device.

64. The method of claim 63 wherein the expander is a balloon adapted to be inflated.

65. The method of claim 63 wherein the at least one Peltier device includes a plurality of Peltier devices stacked one on top of another to increase the overall thermal energy differential.

66. The method of claim 63 further including a temperature control to adjust and monitor the temperature of the therapy plate and vessel temperature.

67. The method of claim 63 further including a control box having a readout for artery wall temperature and therapy plate temperature.

69. The apparatus of claim 68 further comprising at least one temperature sensor located on the tissue-contacting surface of the therapy plate for sensing a variation in blood vessel tissue temperature.

70. The apparatus of claim 69 further including an additional sensor embedded in the therapy plate for detecting the temperature of the therapy plate.

71. The apparatus of claim 69 wherein the temperature sensor is a thermocouple or thermistor.

72. The apparatus of claim 68 wherein the heat exchanger has an aperture extending the length of the heat exchanger for the passage of blood.

73. The apparatus of claim 72 wherein blood carries away the additional energy generated by the at least one Peltier device.

74. The apparatus of claim 72 wherein the aperture is lined with internal starburst fins.

75. The apparatus of claim 72 wherein the heat exchanger includes a serrated blood-contacting plate having a plurality of recesses.

76. The apparatus of claim 68 wherein the catheter assembly includes an elastic balloon adapted to be inflated with a fluid.

77. The apparatus of claim 68 wherein the at least one Peltier device includes a plurality of Peltier devices stacked one on top of another to increase the overall energy differential.

78. The apparatus of claim 68 further including a temperature control to monitor the temperature of the therapy plate.

79. The apparatus of claim 68 further including a control box having a digital readout for blood vessel wall temperature and therapy plate temperature.

80. The apparatus of claim 68 wherein the catheter assembly includes a catheter having an electrode on its distal tip.

48. A method of solidifying plaque on the interior of a blood vessel comprising the steps of:

inserting a catheter assembly into the blood vessel;

advancing the assembly in the blood vessel;

stopping at a plurality of predetermined locations along the blood vessel such contact the interior wall of the blood vessel;

sensing variation in blood vessel temperature at the plurality of predetermined locations along the interior wall of the blood vessel using a plurality of temperature detectors; and

applying thermal energy to, or removing thermal energy from, areas of increased temperature to reduce the possibility of leakage of the plaque into the blood vessel.

68. An apparatus for solidifying plaque on the interior wall of a blood vessel comprising:

a catheter assembly having a collapsed configuration and an expanded configuration, the catheter assembly being in the collapsed configuration during insertion into and advancement through a blood vessel, the catheter assembly being in the expanded configuration during solidification of the plaque;

at least one Peltier device having a hot side and a cold side for solidifying plaque on the interior wall of the blood vessel, the at least one Peltier device being powered by an electrical current having a polarity wherein the polarity of the electrical current can be reversed to change the hot side to the cold side and/or vice-versa;

a plurality of temperature detectors adapted to contact the interior wall of the blood vessel to identify areas of increased temperature indicative of inflamed and/or unstable plaque;

a heat exchanger which removes undesired energy generated by the at least one Peltier device; and

a therapy plate positioned in between the at least one Peltier device and the interior of the blood vessel wall, the therapy plate having a tissue-contacting surface adapted to contact the interior of the vessel wall.