Method and system for mass spectroscopy
First Claim
1. A method of determining the ratio of mass to charge of an ion comprising:
- a. pulsed ionizing intact analyte ions from a sample to be analyzed;
b. simultaneously i.) damping said intact ions to reduce energy spread of said ions substantially without fragmentation, and ii.) linearly accelerating said intact ions to provide a substantially continuous beam thereof; and
c. determining ratio of mass to charge of said ions.
2 Assignments
0 Petitions
Accused Products
Abstract
A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.
14 Citations
66 Claims
-
1. A method of determining the ratio of mass to charge of an ion comprising:
-
a. pulsed ionizing intact analyte ions from a sample to be analyzed;
b. simultaneously i.) damping said intact ions to reduce energy spread of said ions substantially without fragmentation, and ii.) linearly accelerating said intact ions to provide a substantially continuous beam thereof; and
c. determining ratio of mass to charge of said ions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
-
-
37. A system for determining the ratio of mass to charge of an ion comprising:
-
a. a pulsed ionizer which generates intact analyte ions from a sample of matter to be analyzed;
b. a high pressure co-linear ion guide/accelerator interfaced with said ion source for non-accelerated receipt of intact ions of said sample, which simultaneously dampens and linearly accelerates intact ions in the substantial absence of fragmentation of said ions to provide a substantially continuous beam of said intact ions for mass analysis; and
c. a mass analyzer connected to said ion guide/accelerator for receipt of said beam of ions which determines the mass to charge ratio of said intact ions.
-
Specification