Bile-acid prodrugs of L-dopa and their use in the sustained treatment of parkinsonism
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Abstract
Bile-acid conjugates useful for sustained release of L-DOPA, inhibitors of catechol O-methyl transferase and/or inhibitors of L-aromatic amino acid decarboxylase are provided.
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37 Claims
- 1. A compound of formula (I):
- 2. A compound of formula (I-a):
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3. A compound of the formula (I-b):
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4. A compound of formula (I-c):
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37. A compound of formula
D-Y-T wherein: -
D is a member selected from the group consisting of L-DOPA, a catechol O-methyl transferase inhibitor, an inhibitor of a L-aromatic amino acid decarboxylase, and derivatives of L-DOPA;
Y is a cleavable linker; and
T is a substrate for an intestinal bile acid transporter.
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Specification