System and method for programmably controlling electrode activation sequence in a multi-site cardiac stimulation device

• US 20020151934A1
• Filed: 07/11/2001
• Published: 10/17/2002
• Est. Priority Date: 04/12/2001
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Levine, Paul A.
• Granted Patent: US 6,473,645 B1
• Time in Patent Office: Days
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3918 characterised by shock pathway, e.g. by electrode configuration

Abstract

An implantable multi-chamber cardiac stimulation device includes flexibly programmable electrode sensing configurations, and is capable of precisely controlling the stimulation sequence between multiple sites. The stimulation device provides a plurality of connection ports that allow independent connection of each electrical lead associated with a particular stimulation site in the heart. Each connection port further provides a unique terminal for making electrical contact with only one electrode such that no two electrodes are required to be electrically coupled. Furthermore, each electrode, whether residing on a unipolar, bipolar or multipolar lead, may be selectively connected or disconnected through programmable switching circuitry that determines the electrode configurations to be used for sensing and for stimulating at each stimulation site. The stimulation device possesses unique sensing and output configurations associated with each stimulation site, such that depolarizations occurring at each stimulation site can be detected independently of events occurring at other sites within the heart, and such that each site can be stimulated independently of other sites or on a precisely timed basis triggered by events occurring at other sites. The stimulation device is further capable of uniquely programming coupling intervals for precisely controlling the activation sequence of stimulated sites. Coupling intervals are selected so as to provide optimal hemodynamic benefit to the patient.

Claims

1. A method of automatically controlling an activation sequence of a plurality of electrodes that are positioned in multiple cardiac chambers, for use with a multi-site cardiac stimulation device, the method comprising the steps of:

defining a plurality of electrode configurations corresponding to available activation sequences of the electrodes;

selectively delivering a stimulus, on demand, to a cardiac chamber;

sensing a cardiac event in the cardiac chamber by using a first electrode configuration;

initiating a coupling interval for the multiple cardiac chambers;

controlling the activation sequence of the electrodes by selecting an electrode configuration based on the cardiac chamber in which the cardiac event is sensed or a stimulus delivered;

automatically acquiring a measurement of the cardiac event using the electrode configuration; and

automatically adjusting the coupling interval in response to the measurement of the cardiac event.

2. The method according to claim 1, wherein the sensing step includes sensing intrinsic depolarizations in at least two cardiac chambers.

3. The method according to claim 2, wherein the step of delivering a stimulus includes stimulating at least two cardiac chambers.

4. The method according to claim 3, further including the step of determining an inter-atrial conduction (A-A) delay by selecting a coupling interval defined according to whether an intrinsic atrial depolarization is first sensed in a right atrium or in a left atrium.

5. The method according to claim 4, wherein the step of automatically adjusting includes selecting a right-to-left atrial coupling interval to control an interval between an intrinsic right atrial depolarization (P-wave) and a delivery of a left atrial stimulus.

6. The method according to claim 4, wherein the step of automatically adjusting includes selecting a left-to-right atrial coupling interval to control an interval between an intrinsic left atrial depolarization (P-wave) and a delivery of a right atrial stimulus.

7. The method according to claim 1, wherein the step of automatically adjusting further includes adjusting the coupling interval based on a stimulation event in any one of the multiple cardiac chambers.

8. The method according to claim 1, wherein the step of initiating a coupling interval includes initiating a unique coupling interval for a stimulation site, between the stimulation site and remaining stimulation sites, in terms of any one or more of:

a stimulations event or an intrinsic depolarization occurring at the stimulation site.

9. The method according to claim 1, further including sensing an occurrence of an intrinsic atrial depolarization in any one or more of a left atrium or a right atrium.

10. The method according to claim 9, further including delivering a right atrial stimulation pulse when no intrinsic atrial depolarization is sensed.

11. The method according to claim 10, wherein the step of initiating the coupling interval includes initiating one or more coupling intervals from the right atrial stimulation pulse to any one or more of:

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

12. The method according to claim 10, further including detecting an occurrence of an intrinsic right atrial depolarization.

13. The method according to claim 12, wherein when the intrinsic right atrial depolarization is not sensed, initiating one or more coupling intervals from the intrinsic right atrial depolarization to any one or more of:

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

14. The method according to claim 13, wherein when an intrinsic left atrial depolarization is sensed, initiating one or more coupling intervals from the intrinsic left atrial depolarization to any one or more of:

a right atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

15. The method according to claim 1, further including automatically selecting a sensing polarity for each sensing site in the multiple cardiac chambers.

16. The method according to claim 15, wherein the step of automatically selecting the sensing polarity includes designating any of an anode or a cathode assignment to at least one of the plurality of sensing electrodes.

17. The method according to claim 16, wherein the step of designating includes selecting a left ventricular tip electrode as the cathode, and further selecting a right ventricular tip electrode as the anode.

18. The method according to claim 16, wherein the step of designating includes selecting a right ventricular tip electrode as the cathode, and further selecting a left ventricular tip electrode as the anode.

19. The method according to claim 16, wherein the step of designating includes assigning any of an anodal sensing or a cathodal sensing to at least one of the plurality of sensing electrodes.

20. The method according to claim 16, wherein the step of designating includes assigning any of an anodal sensing or a cathodal sensing to at least one of the plurality of sensing electrodes.

21. The method according to claim 16, further including automatically selecting a stimulation polarity for each stimulation site in the multiple cardiac chambers.

22. The method according to claim 21, wherein the step of automatically selecting the stimulation polarity includes designating any of an anode or a cathode assignment to at least one of a plurality of stimulation electrodes.

23. The method according to claim 22, wherein the step of designating includes selecting a left ventricular tip electrode as the cathode, and further selecting a right ventricular tip electrode as the anode.

24. The method according to claim 22, wherein the step of designating includes selecting a right ventricular tip electrode as the cathode, and further selecting a left ventricular tip electrode as the anode.

25. The method according to claim 22, wherein the step of designating includes assigning any of an anodal sensing or a cathodal sensing to at least one of the plurality of sensing electrodes.

26. The method according to claim 1, further including allowing intrinsic depolarizations occurring at each stimulation site to be sensed independently.

27. The method according to claim 1, wherein the step of automatically adjusting the coupling interval includes determining a current stimulation state of the stimulation device;

when the stimulation device is stimulating a ventricle, attempting to inhibit ventricular stimulation by extending an atrial-ventricular (AV) delay;

when the stimulation device is stimulating an atrium, attempting to inhibit atrial pacing by reducing a base pacing rate;

measuring one or more baseline physiological parameters; and

modulating one or more combinations of the coupling intervals for altering the activation sequence so as to determine an activation sequence that allows optimal improvement in the current stimulation state.

29. The stimulation device according to claim 28, wherein the discriminator senses an occurrence of an intrinsic atrial depolarization in any one or more of a left atrium or a right atrium.

30. The stimulation device according to claim 29, wherein the pulse generator delivers a right atrial stimulation pulse in the absence of an intrinsic atrial depolarization.

31. The stimulation device according to claim 29, wherein the timing control circuitry initiates one or more coupling intervals from a right atrial stimulation pulse to any one or more of:

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

32. The stimulation device according to claim 29, wherein the sensing circuitry is adapted to further sense an occurrence of an intrinsic right atrial depolarization;

and

wherein in the absence of an intrinsic right atrial depolarization, the timing control circuitry initiates one or more coupling intervals from the intrinsic right atrial depolarization to any one or more of;

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

33. The stimulation device according to claim 29, wherein in the presence of an intrinsic left atrial depolarization, the sensing circuitry initiates one or more coupling intervals from the intrinsic left atrial depolarization to any one or more of:

a right atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

34. The stimulation device according to claim 28, wherein the plurality of electrodes include sensing electrodes;

and

further including a switch bank that automatically selects polarities for the plurality of sensing electrodes.

35. The stimulation device according to claim 30, wherein the plurality of electrodes include stimulation electrodes;

and

further including a switch bank that automatically selects polarities for the plurality of stimulation electrodes.

36. The stimulation device according to claim 30, further including a multi-port connector for connection to any one or more of uni-polar, bi-polar, or multi-polar leads.

37. The stimulation device according to claim 36, wherein the multi-port connector includes four bipolar connection ports:

a left ventricular connection port that couples to a left ventricular lead with terminals associated with a ventricular tip electrode, a left ventricular ring electrode, and a left atrial coil electrode;

a left atrial connection port that couples to a left atrial lead with terminals associated with a left atrial tip electrode and a left atrial ring electrode;

a right ventricular connection port that couples to a right ventricular lead with terminals associated with a right ventricular tip electrode, a right ventricular ring electrode, a right ventricular shocking coil, and a right ventricular coil electrode; and

a right atrial connection port that couples to a right atrial lead with terminals associated with a right atrial tip electrode and a right atrial ring electrode.

39. The stimulation device according to claim 38, wherein the sensing means senses an occurrence of an intrinsic atrial depolarization in any one or more of a left atrium or a right atrium.

40. The stimulation device according to claim 39, wherein the means for generating stimulation energy delivers a right atrial stimulation pulse in the absence of an intrinsic atrial depolarization;

wherein the initiating means initiates one or more coupling intervals from a right atrial stimulation pulse to any one or more of;

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse;

wherein in the absence of an intrinsic right atrial depolarization, the initiating means initiates one or more coupling intervals from the intrinsic right atrial depolarization to any one or more of;

a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse; and

wherein in the presence of an intrinsic left atrial depolarization, the initiating means initiates one or more coupling intervals from the intrinsic left atrial depolarization to any one or more of;

a right atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.

41. The stimulation device according to claim 38, wherein the plurality of electrodes include sensing electrodes;

and

further including switching means for automatically selecting polarities for the plurality of sensing electrodes.

42. The stimulation device according to claim 38, wherein the plurality of electrodes include stimulation electrodes;

and

further including switching means for automatically selecting polarities for the plurality of stimulation electrodes.

43. The stimulation device according to claim 38, further including a multi-port connecting means for connection to any one or more of uni-polar, bi-polar, or multi-polar leads;

and

wherein the multi-port connecting means includes four bipolar connection ports;

a left ventricular connection port that couples to a left ventricular lead with terminals associated with a ventricular tip electrode, a left ventricular ring electrode, and a left atrial coil electrode;

a left atrial connection port that couples to a left atrial lead with terminals associated with a left atrial tip electrode and a left atrial ring electrode;

a right ventricular connection port that couples to a right ventricular lead with terminals associated with a right ventricular tip electrode, a right ventricular ring electrode, a right ventricular shocking coil, and a right ventricular coil electrode; and

a right atrial connection port that couples to a right atrial lead with terminals associated with a right atrial tip electrode and a right atrial ring electrode.

28. A multi-site cardiac stimulation device capable of automatically controlling an activation sequence of a plurality of electrodes that are positioned in multiple cardiac chambers, comprising:

a discriminator, coupled to the plurality of electrodes, that senses a cardiac signal in each of the cardiac chambers, and that identifies a cardiac chamber of origin in which the cardiac signal originates;

a pulse generator, connected to the electrodes, to selectively deliver stimulation pulses on demand to the cardiac chambers; and

timing control circuitry, connected to the electrodes, the pulse generator, and the discriminator to initiate coupling intervals for the multiple cardiac chambers based on the cardiac chamber of origin in which an intrinsic depolarization is sensed or a stimulus is delivered, for controlling a timing of the activation sequence, and the timing control circuitry further automatically adjusting the coupling intervals based on measurements acquired by the discriminator.

38. A multi-site cardiac stimulation device capable of automatically controlling an activation sequence of a plurality of electrodes that are positioned in multiple cardiac chambers, comprising:

means for sensing a cardiac signal in each of the multiple cardiac chambers;

means for detecting a cardiac chamber of origin in which the cardiac signal originates;

means for selectively generating stimulation energy, on demand, to the multiple cardiac chambers; and

means for initiating coupling intervals for the multiple cardiac chambers based on the cardiac chamber of origin in which an intrinsic depolarization is sensed or a stimulus is delivered, for controlling a timing of the activation sequence, and for automatically adjusting the coupling intervals based on measurements acquired by the sensing means.