Delivery of reactive agents via multiple emulsions for use in shelf stable products

• US 20020155080A1
• Filed: 03/05/2001
• Published: 10/24/2002
• Est. Priority Date: 03/05/2001
• Status: Active Grant

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Glenn, Robert Wayne Jr., Tadros, Tharwat, Deckner, George Endel, McMeekin, Anthony
• Granted Patent: US 6,936,264 B2
• Time in Patent Office: Days
• US Class Current: 424/70.5
• CPC Class Codes: A61K 8/066 Multiple emulsions, e.g. water-in-oil-in-water
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 5/06 Preparations for styling the hair, e.g. by temporary shaping or colouring
• CPC Class Codes: A61Q 5/12 Preparations containing hair conditioners

Abstract

Emulsion treatment compositions comprise an aqueous continuous phase and a discontinuous phase in the form of an oil-in-oil emulsion. The oil-in-oil emulsion comprises a reactive component including a reactive agent and an internal oil, wherein the internal oil solubilizes the reactive agent, and a middle oil in which the reactive component is dispersed. The middle oil is immiscible with the internal oil, does not solubilize the reactive agent, is immiscible in the aqueous continuous phase, and includes a hydrophobic particulate thickener. Methods for treating hair comprise applying the emulsion treatment compositions to hair.

Claims

1. An emulsion treatment composition comprising:

a) an aqueous continuous phase; and

b) a discontinuous phase in the form of an oil-in-oil emulsion, the discontinuous phase including;

i) a reactive component including a reactive agent and an internal oil, wherein the internal oil solubilizes the reactive agent, and

ii) a middle oil in which the reactive component is dispersed, wherein the middle oil is immiscible with the internal oil, does not solubilize the reactive agent, is immiscible in the aqueous continuous phase, and includes a hydrophobic particulate thickener.

2. The emulsion treatment composition according to claim 1, wherein the reactive agent is covalently reactive with a keratin substrate.

3. The emulsion treatment composition according to claim 2, wherein the reactive agent is covalently reactive with human hair.

4. The emulsion treatment composition according to claim 3, wherein the reactive agent comprises one or more reactive groups comprising electrophilic groups, nucleophilic groups, protected thiol groups, or mixtures thereof.

5. The emulsion treatment composition according to claim 4, wherein the reactive agent further comprises a cosmetically active functional group.

6. The emulsion treatment composition according to claim 4, wherein the electrophilic reactive group is selected from the group consisting of halotriazine, haloquinoxaline, halopyrimidine, vinylsulfone, β

-haloethylsulfone, β

-sulfatoethylsulfone, acrylate, methacrylate, acrylamide, methacrylamide, maleimide, epoxide, acylhalide, ester, carbamate, dithiocarboxylic acid ester, alkoxysilane, thiosulfate, anhydride, urea derivative, isothiocyanate, isocyanate, lactone, thiosulfate, isothiuronium, and azlactone electrophilic groups, and mixtures thereof.

7. The emulsion treatment composition according to claim 4, wherein the nucleophilic reactive group is selected from the group consisting of thiols, thiolates, thiol-containing quaternary salts, thiolate-containing quaternary salts, thioalkyl esters, thioalkylamides, thiol derivatives of cysteamine, thiolate derivatives of cysteamine, and mixtures thereof.

8. The emulsion treatment composition according to claim 4, wherein the protected thiol reactive group has the general formula:

R—

(S—

Pr)_m

wherein R is a monovalent or multivalent cosmetically active functional group, S is sulfur, Pr is a protecting group and m is an integer from 1 to 100.

9. The emulsion treatment composition according to claim 8, wherein the protected thiol reactive group is selected from the group consisting of heterocyclic protecting groups, Sp² aliphatic trigonal carbon protecting groups, Sp³ carbon electrophilic protecting groups, phosphorus protecting groups, metal based protecting groups, non-metal and metalloid based protecting groups other than phosphorus, energy-sensitive protecting groups, and mixtures thereof.

10. The emulsion treatment composition according to claim 1, wherein the composition comprises from about 0.01% to about 10%, by weight of the emulsion treatment composition, of the reactive agent.

11. The emulsion treatment composition according to claim 1, wherein the internal oil comprises a non-polar solvent selected from the group consisting of volatile silicone compounds, nonvolatile silicone compounds, volatile hydrocarbons, nonvolatile hydrocarbons, and mixtures thereof.

12. The emulsion treatment composition according to claim 1, wherein the internal oil comprises a polar solvent selected from the group consisting of amides, esters, ethers, ketones, cyclic amides, cyclic esters, cyclic ketones, cyclic ethers, and mixtures thereof.

13. The emulsion treatment composition according to claim 1, wherein the composition comprises from about 10% to about 80%, by weight of the oil-in-oil emulsion, of the internal oil.

14. The emulsion treatment composition according to claim 1, wherein the middle oil comprises an oil selected from the group consisting of fatty acid derivatives, cholesterol, cholesterol derivatives, di- and tri-glycerides, vegetable oils, vegetable oil derivatives, liquid nondigestible oils and mixtures thereof.

15. The emulsion treatment composition according to claim 1, wherein the composition comprises from about 25% to about 80%, by weight of the oil-in-oil emulsion, of the middle oil.

16. The emulsion treatment composition according to claim 1, wherein the composition comprises from about 3% to about 20%, by weight of the middle oil phase, of the hydrophobic particulate thickener.

17. The emulsion treatment composition according to claim 16, wherein the thickener comprises a crystalline, hydroxyl-containing stabilizer selected from the group consisting of:

18. The emulsion treatment composition according to claim 16, wherein the hydrophobic particulate thickener comprises a hydrophobically modified dispersed amorphous silica or a hydrophobically modified dispersed smectite clay.

19. The emulsion treatment composition according to claim 1, wherein the aqueous continuous phase comprises water and stabilizing liquid crystals.

20. The emulsion treatment composition according to claim 1, wherein the composition comprises from about 45% to about 90%, by weight of the composition, of the aqueous continuous phase.

22. A method for treating, hair, which method comprises applying an effective amount of the emulsion treatment composition of claim 3 to the hair.

21. An emulsion treatment composition comprising:

a) from about 50% to about 85%, by weight of the emulsion treatment composition, of an aqueous continuous phase; and

b) from about 10% to about 50%, by weight of the emulsion treatment composition, of a discontinuous phase in the form of an oil-in-oil emulsion, the discontinuous phase including

i) a reactive component including from about 1% to about 5%, by weight of the emulsion treatment composition, of a reactive agent and from about 25% to about 60%, by weight of the oil-in-oil emulsion, of an internal oil, wherein the internal oil solubilizes the reactive agent, and

ii) from about 40% to about 60%, by weight of the oil-in-oil emulsion, of a middle oil in which the reactive component is dispersed, wherein the middle oil is immiscible with the internal oil, does not solubilize the reactive agent, is immiscible in the aqueous continuous phase, and comprises from about 5% to about 15%, by weight of the middle oil, of a hydrophobic particulate thickener.