INTEGRATED MULTI-VITAMIN AND MINERAL COMBINATION

• US 20020155163A1
• Filed: 12/27/1999
• Published: 10/24/2002
• Est. Priority Date: 12/27/1999
• Status: Abandoned Application

• Current Assignee: Mariposa Botanicals, Ltd.
• Original Assignee: Mariposa Botanicals, Ltd.
• Inventors: WEIL, ANDREW, BENJAMIN, SAMUEL D.
• Application Number:
  US09/472,669
• Publication Number:
  US 20020155163A1
• Time in Patent Office: Days
• US Class Current: 424/600
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 31/196 the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 31/4188 condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
• CPC Class Codes: A61K 31/4415 Pyridoxine, i.e. Vitamin B6 pyridoxal phosphate A61K31/675
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/51 Thiamines, e.g. vitamin B1
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A daily multi-vitamin and mineral combination for use in the adjunct care of humans with asthma comprising thiamin, riboflavin, niacin, Vitamin B₆, folate, Vitamin B₁₂, biotin, pantothenic acid, choline, inositol, para-amino benzoic acid, Vitamin C, calcium, magnesium, iodine, selenium, manganese, chromium, molybdenum, boron, zinc, potassium, silicon, sulfur, vanadium, citrus bioflavonoid complex, hesperidin complex, rutin, Vitamin A, Vitamin D, Vitamin E, lycopene, lutein, Coenzyme Q10 and N-acetyl cysteine. For adjunct care of humans with diabetes, alpha-lipoic acid is substituted for N-acetyl cysteine and the amount of inositol is increased. A method of supplementing the nutritional intake of humans with diabetes and/or asthma through daily oral administration of the appropriate multi-vitamin and mineral combination.

Claims

1. A multi-vitamin and mineral combination for use in the adjunct care of humans with asthma comprising:

a. approximately 50-100 mg thiamin;

b. approximately 45-55 mg riboflavin;

c. approximately 50-100 mg niacin;

d. approximately 50-100 mg Vitamin B₆;

e. approximately 400-800 μ

g folate;

f. approximately 80-120 μ

g Vitamin B₁₂;

g. approximately 80-220 μ

g biotin;

h. approximately 40-60 mg pantothenic acid;

i. approximately 40-60 mg choline;

j. approximately 40-60 mg inositol;

k. approximately 40-60 mg para-amino benzoic acid;

l. approximately 100-500 mg Vitamin C;

m. approximately 240-600 mg calcium;

n. approximately 120-275 mg magnesium;

o. approximately 120-180 μ

g iodine;

p. approximately 160-240 μ

g selenium;

q. approximately 0.8-1.2 mg manganese;

r. approximately 200-800 μ

g chromium;

s. approximately 60-90 μ

g molybdenum;

t. approximately 5-10 mg boron;

u. approximately 4.5-33 mg zinc;

v. approximately 0.8-1.2 mg potassium;

w. approximately 1.6-2.4 mg silicon;

x. approximately 4-6 mg sulfur;

y. approximately 8-12 μ

g vanadium;

z. approximately 32-48 mg citrus bioflavonoid complex;

aa. approximately 3.2-4.8 mg hesperidin complex;

bb. approximately 32-48 mg rutin;

cc. approximately 15,000-25,000 IU Vitamin A;

dd. approximately 320-480 IU Vitamin D;

ee. approximately 400-880 IU Vitamin E;

ff. approximately 4-6 mg lycopene;

gg. approximately 4.8-7.2 mg lutein;

hh. approximately 15-60 mg Coenzyme Q10; and

ii. approximately 540-660 mg N-acetyl cysteine.

2. The multi-vitamin and mineral combination of claim 1, wherein said thiamin, riboflavin, niacin, Vitamin B₆, folate, Vitamin B₁₂, biotin, pantothenic acid, choline, inositol, para-amino benzoic acid, Vitamin C, calcium, magnesium, iodine, selenium, manganese, chromium, molybdenum, boron, zinc potassium, silicon, sulfur, vanadium, citrus bioflavonoid complex, hesperidin complex, and rutin are combined in a first formulation;

said Vitamin A, Vitamin D, Vitamin E, lycopene, lutein and Coenzyme Q10 are combined in a second formulation; and

said N-acetyl cysteine is in a third formulation.

3. A method of supplementing nutritional intake of humans with asthma by administering the multi-vitamin and mineral combination of claim 2.

4. The method of claim 3, wherein said first formulation of said multi-vitamin and mineral composition is administered orally.

5. The method of claim 4, wherein said first formulation of said multi-vitamin and mineral composition is administered in the form of a tablet and further comprises micro-crystalline cellulose, stearic acid and magnesium stearate.

6. The method of claim 3, wherein said second formulation of said multi-vitamin and mineral composition is administered orally.

7. The method of claim 6, wherein said second formulation of said multi-vitamin and mineral combination is administered in the form of a softgel capsule and further comprises soybean oil, gelatin, water, glycerin, beeswax, and caramel.

8. The method of claim 3, wherein said third formulation of said multi-vitamin and mineral composition is administered orally.

9. The method of claim 8, wherein said third formulation of said multi-vitamin and mineral composition is administered in the form of a tablet and further comprises micro-crystalline cellulose, stearic acid and magnesium stearate.

19. The multi-vitamin and mineral combination of claim 1 or claim 10, wherein said Vitamin C is incorporated as Ester C®

.

20. The multi-vitamin and mineral combination of claim 1 or claim 10, wherein said selenium is yeast-bound.

21. The multi-vitamin and mineral combination of claim 1 or claim 10 wherein said sulfur is incorporated as methylsulfonylmethane.

10. A multi-vitamin and mineral combination for use in the adjunct care of humans with diabetes comprising:

a. approximately 50-100 mg thiamin;

b. approximately 45-55 mg riboflavin;

c. approximately 50-100 mg niacin;

d. approximately 50-100 mg Vitamin B₆;

e. approximately 400-800 μ

g folate;

f. approximately 80-120 μ

g Vitamin B₁₂;

g. approximately 80-220 μ

g biotin;

h. approximately 40-60 mg pantothenic acid;

i. approximately 40-60 mg choline;

j. approximately 540-660 mg inositol;

k. approximately 40-60 mg para-amino benzoic acid;

l. approximately 100-500 mg Vitamin C;

m. approximately 240-600 mg calcium;

n. approximately 120-275 mg magnesium;

o. approximately 120-180 μ

g iodine;

p. approximately 160-240 μ

g selenium;

q. approximately 0.8-1.2 mg manganese;

r. approximately 200-800 μ

g chromium;

s. approximately 60-90 μ

g molybdenum;

t. approximately 5-10 mg boron;

u. approximately 4.5-33 mg zinc;

v. approximately 0.8-1.2 mg potassium;

w. approximately 1.6-2.4 mg silicon;

x. approximately 4-6 mg sulfur;

y. approximately 8-12 μ

g vanadium;

z. approximately 32-48 mg citrus bioflavonoid complex;

aa. approximately 3.2-4.8 mg hesperidin complex;

bb. approximately 32-48 mg rutin;

cc. approximately 15,000-25,000 IU Vitamin A;

dd. approximately 320-480 IU Vitamin D;

ee. approximately 400-880 IU Vitamin E;

ff. approximately 4-6 mg lycopene;

gg. approximately 4.8-7.2 mg lutein;

hh. approximately 15-60 mg Coenzyme Q10; and

ii. approximately 90-100 mg alpha-lipoic acid.

11. The multi-vitamin and mineral combination of claim 10, wherein said thiamin, riboflavin, niacin, Vitamin B₆, folate, Vitamin B₁₂, biotin, pantothenic acid, choline, para-amino benzoic acid, Vitamin C, calcium, magnesium, iodine, selenium, manganese, chromium, molybdenum, boron, zinc potassium, silicon, sulfur, vanadium, citrus bioflavonoid complex, hesperidin complex, rutin, and approximately 40-60 mg of said inositol are combined in a first formulation;

said Vitamin A, Vitamin D, Vitamin E, lycopene, lutein and Coenzyme Q10 are combined in a second formulation; and

said alpha-lipoic acid and approximately 500-600 mg of said inositol are combined in a third formulation.

12. A method of supplementing nutritional intake of humans with diabetes by administering the multi-vitamin and mineral combination of claim 11.

13. The method of claim 12, wherein said first formulation of said multi-vitamin and mineral composition is administered orally.

14. The method of claim 13, wherein said first formulation of said multi-vitamin and mineral composition is administered in the form of a tablet and further comprises micro-crystalline cellulose, stearic acid and magnesium stearate.

15. The method of claim 12, wherein said second formulation of said multi-vitamin and mineral composition is administered orally.

16. The method of claim 15, wherein said second formulation of said multi-vitamin and mineral combination is administered in the form of a softgel capsule and further comprises soybean oil, gelatin, water, glycerin, beeswax, and caramel.

17. The method of claim 12, wherein said third formulation of said multi-vitamin and mineral composition is administered orally.

18. The method of claim 17, wherein said third formulation of said multi-vitamin and mineral composition is administered in the form of a tablet and further comprises micro-crystalline cellulose, stearic acid and magnesium stearate.