Method of determining concentration of glucose in blood
First Claim
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1. A method of determining glucose concentration G(t) in blood of comprising:
- measuring a total impedance of a skin and calculating G(t) according to an expression
performing preliminary stage measurements during a time interval T comprising measuring a total impedance of a skin and a glucose concentration Ginv(t) using an invasive method; and
using the determined total impedance and the glucose concentration Ginv(t) to determine parameters a0, q and a1 by approximating Ginv(t) to G(t) measured during the time interval T of the preliminary stage measurements.
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Abstract
A method of non-invasive determination of a glucose concentration in blood based on the measurements of the total impedance of the skin of a patient is disclosed. The method is based on a linear model of a first order correlation between the glucose concentration and the total impedance, the model taking into account the rate of change of the glucose concentration. The coefficients used in an approximating function are determined at the preliminary stage measurements by an invasive method.
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Citations
18 Claims
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1. A method of determining glucose concentration G(t) in blood of comprising:
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measuring a total impedance of a skin and calculating G(t) according to an expression
performing preliminary stage measurements during a time interval T comprising measuring a total impedance of a skin and a glucose concentration Ginv(t) using an invasive method; and
using the determined total impedance and the glucose concentration Ginv(t) to determine parameters a0, q and a1 by approximating Ginv(t) to G(t) measured during the time interval T of the preliminary stage measurements. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of determining glucose concentration G(tm) in blood of comprising:
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performing discreet measurements of a total impedance of a skin and calculating G(tm) according to an expression
performing preliminary stage measurements during a time interval T comprising measuring a total impedance of a skin and a glucose concentration Ginv(t) using an invasive method; and
using the determined total impedance and the glucose concentration Ginv(t) to determine parameters a0, q and a1 by approximating Ginv(t) to G(tm) measured during the time interval T of the preliminary stage measurements. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification