Medical device for flow augmentation in patients with occlusive cerebrovascular disease and methods of use

• US 20020156455A1
• Filed: 04/25/2000
• Published: 10/24/2002
• Est. Priority Date: 01/15/1999
• Status: Active Grant

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Denise Barbut
• Inventors: Barbut, Denise
• Granted Patent: US 6,558,356 B2
• Time in Patent Office: Days
• US Class Current: 604/509
• CPC Class Codes: A61B 17/3207 Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016
• CPC Class Codes: A61M 1/3613 Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

The invention provides a medical device having first and second elongate tubular members. Each member comprises a manometer at a distal end and a lumen communicating with a port at the distal end. An expandable occlusive member is optionally mounted on either or both tubular members proximal to the distal port. A proximal end of each tubular member is adapted for attachment to an oxygenator and/or a pump for aspirating blood from an artery or a symptomatic carotid artery through the first tubular member and perfusing the blood into the contralateral carotid artery through the second tubular member, thereby providing a means of augmenting the collateral vasculature and maintaining perfusion distal to the offending lesion. The flow rate of blood can be controlled by inflating or deflating the balloon occluder. The device may employ a neuroprotective agent, hypothermic perfusion, and an atherectomy device or an extracorporeal pumping mechanism to remove a vascular occlusion and reestablish cerebral perfusion. Methods of using the devices in treating patients with acute stroke or occlusive cerebrovascular disease are also disclosed.

Claims

1. A medical device for augmenting contralateral circulation in a patient having carotid stenosis, comprising:

a first elongate tubular member having a lumen communicating with a port at a distal end, a manometer carried at the distal end, and an expandable occlusive member carried proximal to the distal port and adapted to expand and engage the lumen of a first carotid artery having a stenosis;

a second elongate tubular member having a lumen communicating with a port at a distal end, a manometer carried at the distal end, and an expandable occlusive member carried proximal to the distal port and adapted to expand and engage the lumen of a second carotid artery; and

a pump connected to the proximal end of the first tubular member and the proximal end of the second tubular member for aspirating blood through the first tubular member and perfusing the blood through the second tubular member.

2. The medical device of claim 1, wherein the port and lumen of each tubular member are adapted for infusion of fluid and pharmaceutical agents.

3. The medical device of claim 2, wherein the pharmaceutical agent is a neuroprotective agent.

4. The medical device of claim 2, wherein the pharmaceutical agent is heparin.

5. The medical device of claim 1, wherein the second tubular member further comprises an additional lumen and port for infusion of fluid and pharmaceutical agent.

6. The medical device of claim 1, wherein the first and second tubular members are carried within the lumen of an elongate catheter.

7. The medical device of claim 1, wherein the proximal end of the first tubular member includes a blood filter.

8. The medical device of claim 1, wherein the proximal end of the second tubular member includes a blood filter.

9. The medical device of claim 1, wherein the lumen of the second tubular member communicates with a plurality of perfusion ports.

10. The medical device of claim 1, wherein the first tubular member further comprises an additional lumen adapted for introduction of an atherectomy device.