Detector array for optical spectrographs

• US 20020161289A1
• Filed: 04/30/2001
• Published: 10/31/2002
• Est. Priority Date: 04/30/2001
• Status: Abandoned Application

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Hopkins, George W. II, Ranganath, Tirumala R., Mauze, Ganapati R.
• Application Number:
  US09/846,489
• Publication Number:
  US 20020161289A1
• Time in Patent Office: Days
• US Class Current: 600/322
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001

Abstract

A composite detector device that incorporates a plurality of types of detector elements to cover a broad wavelength range. There may be one or more individual detector elements of each detector type. The individual detector elements are positioned upon a single substrate so that when light from a sample passes through a spectral dispersing element, each detector element is exposed to light of a predetermined, limited wavelength range.

Claims

1. A device for detecting light from a sample, wherein said light is spatially dispersed in a wavelength dependent manner, the device comprising a plurality of detector elements upon a single substrate, each detector element being located on the substrate such that each said detector element receives a limited wavelength region of the light, the number of detector elements and the number of limited wavelength regions being between 2 and 100.

2. The device of claim 1, wherein at least one detector element has a composition selected from the group consisting of silicon, germanium, indium-gallium-arsenide, strained indium-gallium-arsenide, indium-arsenide, lead-sulfide, lead-selenide, mercury-cadmiumtelluride, and indium-antimonide.

3. The device of claim 1, wherein the composition of one detector element is different from the composition of at least one other detector element.

4. The device of claim 1, wherein the substrate is upon a thermoelectric cooling material.

5. The device of claim 1, wherein each limited wavelength region is between 1 nanometer and 1.2 micrometers wide.

6. The device of claim 1, further comprising a packaging material substantially surrounding the detector elements upon the substrate, said packaging material having at least one opening allowing transmission of light to the detector elements.

7. The device of claim 1, wherein the number of detector elements and number of limited wavelength regions are selected to optimize information obtained about the sample while limiting or minimizing the number of detector elements present on the substrate.

8. The device of claim 1, wherein each detector element may be separately interrogated.

9. An instrument comprising the device of claim 1, wherein the instrument noninvasively measures a blood chemistry value of a subject.

10. The instrument of claim 9, wherein the blood chemistry value measured is selected from the group consisting of blood glucose concentration, blood gases, pH, potassium concentration, lipid concentration, ketone concentration, cholesterol concentration, and bile salt concentration.

11. A method of obtaining a blood chemistry measurement from a subject, the method comprising the steps of

a) shining light from at least one light source upon the body of a subject,

b) receiving light from the body of the subject which contains information about the blood chemistry of the subject,

c) focusing and/or filtering the light received from the body of the subject,

d) casting the focused and/or filtered light upon a composite detector device, said composite detector device having a limited number of detector elements, each detector element receiving a limited wavelength region of the light, wherein the limited wavelength region of light received by each detector element is predetermined for optimizing the information obtained about the blood chemistry of the subject while reducing or minimizing the number of detector elements in the composite detector device,

e) receiving information about the blood chemistry of the subject from the composite detector device, said information being about a limited number of wavelength regions of light,

f) using the information received in step e) to calculate the blood chemistry measurement from the subject.

12. The method of claim 11, wherein multiple narrow-band light sources are used.

13. The method of claim 11, wherein step c) includes spatially separating the light in a wavelength dependent manner.

14. The method of claim 11, wherein each limited wavelength region of light is between 1 nanometer and 1.2 micrometers wide.

15. The method of claim 11, wherein the blood chemistry measurement is blood glucose concentration, the number of optical sensing elements is at least three, and the limited wavelength region of light received by the at least three optical sensing elements are located between about 600 nm and about 900 nm, between about 1400 and about 1800 nm, and between about 2100 and about 2400 nm, respectively.

16. A method of designing a composite detector device for obtaining information about a sample, the method comprising the steps of

a. using a detector to obtain spectral information about the sample at varying conditions of concentration, temperature, and varying amounts of additional materials in the sample which also produce a spectral signal at wavelengths used to study the sample,

b. using multivariate analysis of the spectral information obtained in step a) to optimize the number of detector elements, the wavelength region sensed by each detector element, and the position of the detector element in the composite detector device.