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Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent

  • US 20020161323A1
  • Filed: 12/10/2001
  • Published: 10/31/2002
  • Est. Priority Date: 02/13/2001
  • Status: Active Grant
First Claim
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1. A method of increasing the battery life of an alternating current iontophoretic device used to transport a compound of interest through a localized region of a patient'"'"'s body tissue, comprising:

  • (a) applying an alternating current to a localized region of body tissue having an inherent barrier limiting the transport of compounds therethrough, the alternating current generated using an alternating current iontophoretic device and applied at a level sufficient both to decrease the electrical resistance of the body tissue to a target resistance level and to maintain the electrical resistance of the body tissue at said target level; and

    (b) either prior to, during, or both prior to and during application of the alternating current, delivering to the localized region of body tissue an amount of at least one barrier-modifying agent effective to alter the penetration barrier so as to reduce the voltage level necessary to achieve and maintain said target resistance level thereby facilitating transport of a compound of interest across the body tissue.

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