Cerebral temperature control
First Claim
1. A method for brain hypothermia, said method comprising, in a first phase to enable an early and fast inset of the hypothermia, the steps of:
- providing a container with an infusion solution having a first temperature and a venous infusion catheter connected to an outlet of said container, said venous infusion catheter having an infusion solution lumen;
percutaneously inserting a distal end of said venous infusion catheter into a peripheral vein;
cooling the infusion solution to a second temperature lower than said first temperature; and
infusing a first amount of said cold infusion solution into said vein via the infusion solution lumen of said venous infusion catheter shortly after said cooling, to enable the cold infusion solution to cool the blood flowing to the brain while avoiding air bubbles arising in the infusion solution.
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Accused Products
Abstract
The present invention relates to a method and equipment for controlling the temperature of the brain or brain hemisphere. More specifically the present invention refers to a method and equipment for quick and efficient control of the temperature of the brain and for maintaining a low temperature in the brain. The inventive concept can be divided into three phases. Firstly, an emergency whole body temperature control phase providing a quick temperature control at for example a scene of accident. Secondly, a brain-selective temperature control phase providing a more efficient temperature control at for example an emergency room and thirdly, a maintained temperature control phase providing an even more efficient temperature control for a selected period of time.
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Citations
68 Claims
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1. A method for brain hypothermia, said method comprising, in a first phase to enable an early and fast inset of the hypothermia, the steps of:
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providing a container with an infusion solution having a first temperature and a venous infusion catheter connected to an outlet of said container, said venous infusion catheter having an infusion solution lumen;
percutaneously inserting a distal end of said venous infusion catheter into a peripheral vein;
cooling the infusion solution to a second temperature lower than said first temperature; and
infusing a first amount of said cold infusion solution into said vein via the infusion solution lumen of said venous infusion catheter shortly after said cooling, to enable the cold infusion solution to cool the blood flowing to the brain while avoiding air bubbles arising in the infusion solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method for brain hypothermia comprising, to enable a brain-selective hypothermia, the steps of:
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providing a container with an infusion solution having a first temperature and an arterial infusion catheter connected to an outlet of said container, said arterial infusion catheter having an infusion solution lumen;
percutaneously inserting a distal end of said arterial infusion catheter into an artery in the vicinity of a branch artery supplying blood to the brain;
cooling the infusion solution to a second temperature lower than said first temperature; and
infusing an amount of said cold infusion solution into said artery via the infusion solution lumen of said arterial infusion catheter shortly after said cooling, to enable the cold infusion solution to cool the blood flowing to the brain while avoiding air bubbles arising in the infusion solution and an efficient temperature regulation of the brain.
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29. A method for brain hypothermia comprising, to enable a maintained hypothermia, the steps of:
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inserting into a blood vessel an extraction catheter for extraction of blood;
inserting an arterial infusion catheter in the vicinity of an artery supplying blood to the brain;
establishing an second extra-corporeal blood circuit for cooled blood between said extraction catheter and said arterial infusion catheter via a pumping means and a cooling device capable of cooling extracted blood;
inserting a venous infusion catheter into a vein of the venous system;
establishing a first extra-corporeal blood circuit for heated blood between said extraction catheter and said venous infusion catheter via said pumping means and a heating device capable of heating extracted blood;
extracting blood from said blood vessel via said extraction catheter into said first and second extra-corporeal blood circuit;
cooling a second amount of said extracted blood;
infusing said cooled second amount of extracted blood to said brain supplying artery via said arterial infusion catheter;
heating a first amount of said extracted blood;
infusing said heated first amount of extracted blood to said venous system via said venous infusion catheter.
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30. A method for brain hypothermia, said method comprising the steps of:
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providing a container with a cold infusion solution and an infusion catheter connected to an outlet of said container, said infusion catheter having an infusion solution lumen;
percutaneously inserting a distal end of said infusion catheter into a blood vessel that supplies the brain with blood;
infusing the cold infusion solution into said blood vessel, to enable the cold infusion solution to flow distally to the brain.
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31. A method of achieving thermal regulation of a selected brain hemisphere, said method comprising:
infusing a solution having a first predetermined temperature into a blood vessel supplying said brain hemisphere with blood until said brain hemisphere has reached a predetermined temperature or a predetermined maximum amount of solution has been infused. - View Dependent Claims (32, 33, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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34. An equipment for brain hypothermia in a living being, said equipment comprising:
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a container of infusion solution;
a temperature regulating apparatus for said infusion solution;
a flexible elongated infusion catheter, said catheter having a proximal end being attachable to an outlet of said container, said catheter having a sufficiently small diameter to be percutaneously insertable into a blood vessel feeding the brain with blood.
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35. An equipment for brain hypothermia, said equipment comprising, to enable an early and fast inset of the hypothermia:
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a container with an infusion solution having a first temperature and a venous infusion catheter being connectable to an outlet of said container, said venous infusion catheter having an infusion solution lumen;
said venous infusion catheter having a distal end devised to be percutaneously inserted into a peripheral vein;
a cooling device being configured for cooling the infusion solution to a second temperature lower than said first temperature.
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62. An equipment for brain hypothermia comprising, to enable a brain-selective hypothermia:
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a container with an infusion solution having a first temperature and an arterial infusion catheter connectable to an outlet of said container, said arterial infusion catheter having an infusion solution lumen;
a distal end of said arterial infusion catheter being configured to be percutaneously inserted into an artery in the vicinity of a branch artery supplying blood to the brain;
a cooling device configured to cooling the infusion solution to a second temperature lower than said first temperature, to enable the cold infusion solution to cool the blood flowing to the brain while avoiding air bubbles arising in the infusion solution and an efficient temperature regulation of the brain.
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63. An equipment for brain hypothermia comprising, to enable a maintained hypothermia:
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an extraction catheter configured to be inserted into a blood vessel for extraction of blood;
an arterial infusion catheter configured to be inserted in an artery into the vicinity of an artery supplying blood to the brain;
means for establishing an second extra-corporeal blood circuit for cooled blood between said extraction catheter and said arterial infusion catheter via a pumping means and a cooling device capable of cooling extracted blood;
a venous infusion catheter being configured to be inserted into a vein of the venous system;
means for establishing a first extra-corporeal blood circuit for heated blood between said extraction catheter and said venous infusion catheter via said pumping means and a heating device capable of heating extracted blood;
means for extracting blood from said blood vessel via said extraction catheter into said first and second extra-corporeal blood circuit;
a cooling device for cooling a second amount of said extracted blood;
a heating device for heating a first amount of said extracted blood;
and being configured to;
infusing said cooled second amount of extracted blood to said brain supplying artery via said arterial infusion catheter;
infusing said heated first amount of extracted blood to said venous system via said venous infusion catheter.
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64. An equipment for brain hypothermia, comprising:
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a container with a cold infusion solution and an infusion catheter connectable to an outlet of said container, said infusion catheter having an infusion solution lumen;
a distal end of said infusion catheter being configured to be percutaneously inserted into a blood vessel that supplies the brain with blood;
and being configured to infusing the cold infusion solution into said blood vessel, to enable the cold infusion solution to flow distally to the brain.
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65. A catheter, wherein:
the catheter is configured to assume a curvature at its distal part and having a first lumen having a plurality of openings positioned close to a distal end of the catheter and at the outer arc of the curvature;
a second lumen having an opening at the tip of the distal end of the catheter;
a distal part of the catheter tapering from said plurality of openings to said tip of the catheter. - View Dependent Claims (66, 67, 68)
Specification