Mitocidal compositions and methods

• US 20020164381A1
• Filed: 12/18/2001
• Published: 11/07/2002
• Est. Priority Date: 06/30/2000
• Status: Abandoned Application

• Current Assignee: Medicis Pharmaceutical Corporation (Bausch Health Cos., Inc.)
• Original Assignee: Medicis Pharmaceutical Corporation (Bausch Health Cos., Inc.)
• Inventors: Gans, Eugene H., Shacknai, Jonah
• Application Number:
  US10/022,476
• Publication Number:
  US 20020164381A1
• Time in Patent Office: Days
• US Class Current: 424/703
• CPC Class Codes: A61K 31/63 Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
• CPC Class Codes: A61K 33/04 Sulfur, selenium or tellurium; Compounds thereof
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/26 Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/46 containing sulfur A61K8/44 takes precedence
• CPC Class Codes: A61K 8/466 containing sulfonic acid derivatives; Salts
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/08 Antiseborrheics
• CPC Class Codes: A61P 17/12 Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61P 33/14 Ectoparasiticides, e.g. scabicides
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 17/02 containing insect repellants
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/10 : Washing or bathing preparations

Abstract

Methods for the treatment and prevention of cutaneous mites and for the treatment and prevention of cutaneous inflammation of mammalian skin associated with cutaneous mite infestations utilizing compositions comprising sulfur, one or more sulfur derivative and a dermatologically acceptable carrier. The composition is preferably a cleanser.

Claims

1. A method for treatment of infestations of cutaneous mites comprising:

applying a composition to skin, wherein the composition comprises sulfur, one or more sulfur derivative and a dermatologically acceptable carrier.

2. The method of claim 1 further comprising washing the composition from the skin.

3. The method of claim 2 further comprising rewashing the composition from the skin.

4. The method of claim 1 wherein the composition comprises a cleanser.

5. The method of claim 1 wherein the composition has a pH of 6.5 to 8.1.

6. The method of claim 1, 2, or 3 wherein the composition has a pH of about 7.0 to about 8.1.

7. The method of claim 1, 2, or 3 wherein the composition has a pH of about 7.7 to about 8.1.

8. The method of claim 1, 2, or 3 wherein the composition has a pH of about 7.3 to about 7.7.

9. The method of claims 1, 2 or 3 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1.

10. The method of claim 1 wherein the sulfur derivative comprises one or more cationic sulfur compounds.

11. The method of claim 1 wherein the sulfur derivative comprises one or more of the group consisting of selenium sulfide, potassium sulfide, poly-potassium sulfide, and poly-calcium poly-sulfide;

H₂S;

sulfuric acid;

bisulfides;

sulfur dioxide;

thiols;

organic salts;

sodium sulfacetamide;

sulfites; and

mercaptans.

12. The method of claim 1 wherein the sulfur derivative comprises sodium sulfacetamide.

13. The method of claims 1, 2, or 3 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide.

14. The method of claim 11 wherein the sulfur derivative is present in the range of about 10%.

15. The method of claims 1, 2, or 3 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide present in the range of about 10% and wherein the sulfur is present in the range of about 5%.

16. The method of claim 1 wherein the mites are of the genus Demodex.

17. The method of claim 1 wherein the carrier comprises an aqueous base.

18. The method of claim 1 wherein the composition comprises a high sorption base.

19. The method of claim 18 wherein the high sorption base comprises one or more of the group consisting of non-swelling clay, gum, swelling clay and silicon.

20. The method of claim 19 wherein the non-swelling clay comprises kaolin.

21. The method of claim 19 wherein the non-swelling clay is present at about 18.00%.

22. The method of claim 19 wherein the gum comprises xanthan gum.

23. The method of claim 19 wherein the gum is present at about 0.30%.

24. The method of claim 19 wherein the swelling clay comprises magnesium aluminum silicate.

25. The method of claim 19 wherein the swelling clay is present at about 1.50%.

26. The method of claim 19 wherein the silicon comprises silicon dioxide.

27. The method of claim 19 wherein the silicon is present at about 5.00%.

28. The method of claim 19 wherein the composition further comprises water.

29. The method of claim 19 wherein the water is present at about 40-50%.

30. A method for prevention of infestations of cutaneous mites comprising

Applying a composition to skin, wherein the composition comprises sulfur, one or more sulfur derivative and a dermatologically acceptable carrier.

31. The method of claim 30 further comprising washing the composition from the skin.

32. The method of claim 31 further comprising rewashing the composition from the skin.

33. The method of claim 30 wherein the composition comprises a cleanser.

34. The method of claim 30, 31 or 32 wherein the composition has a pH of about 7.0 to about 8.1.

35. The method of claim 30, 31 or 32 wherein the composition has a pH of about 7.7 to about 8.1.

36. The method of claim 30, 31 or 32 wherein the composition has a pH of about 7.3 to about 7.7.

37. The method of claims 30, 31 or 32 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1.

38. The method of claim 30 wherein the sulfur derivative comprises one or more cationic sulfur compounds.

39. The method of claim 30 wherein the sulfur derivative comprises one or more of the group consisting of selenium sulfide, potassium sulfide, poly-potassium sulfide, and poly-calcium poly-sulfide;

H₂S;

sulfuric acid;

bisulfides;

sulfur dioxide;

thiols;

organic salts;

sodium sulfacetamide;

sulfites; and

mercaptans.

40. The method of claim 30 wherein the sulfur derivative comprises sodium sulfacetamide.

41. The method of claims 30, 31, or 32 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide.

42. The method of claim 39 wherein the sulfur derivative is present in the range of about 10%.

43. The method of claims 30, 31, or 32 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide present in the range of about 10% and wherein the sulfur is present in the range of about 5%.

44. The method of claim 30 wherein the mites are of the genus Demodex.

45. The method of claim 30 wherein the carrier comprises an aqueous base.

46. The method of claim 30 wherein the composition comprises a high sorption base.

47. The method of claim 46 wherein the high sorption base comprises one or more of the group consisting of non-swelling clay, gum, swelling clay and silicon.

48. The method of claim 47 wherein the non-swelling clay comprises kaolin.

49. The method of claim 47 wherein the non-swelling clay is present at about 18.00%.

50. The method of claim 47 wherein the gum comprises xanthan gum.

51. The method of claim 47 wherein the gum is present at about 0.30%.

52. The method of claim 47 wherein the swelling clay comprises magnesium aluminum silicate.

53. The method of claim 47 wherein the swelling clay is present at about 1.50%.

54. The method of claim 47 wherein the silicon comprises silicon dioxide.

55. The method of claim 47 wherein the silicon is present at about 5.00%.

56. The method of claim 47 wherein the composition further comprises water.

57. The method of claim 47 wherein the water is present at about 40-50%.

60. The method of claim 59 further comprising washing the composition from the skin.

61. The method of claim 60 further comprising rewashing the composition from the skin.

62. The method of claim 59 wherein the composition comprises a cleanser.

63. The method of claim 59, 60 or 61 wherein the composition has a pH of about 7.0 to about 8.1.

64. The method of claim 59, 60 or 61 wherein the composition has a pH of about 7.7 to about 8.1.

65. The method of claim 59, 60 or 61 wherein the composition has a pH of about 7.3 to about 7.7.

67. The method of claim 59 wherein the sulfur derivative comprises one or more cationic sulfur compounds.

68. The method of claim 59 wherein the sulfur derivative comprises one or more of the group consisting of selenium sulfide, potassium sulfide, poly-potassium sulfide, and poly-calcium poly-sulfide;

H₂S;

sulfuric acid;

bisulfides;

sulfur dioxide;

thiols;

organic salts;

sodium sulfacetamide;

sulfites; and

mercaptans.

69. The method of claim 59 wherein the sulfur derivative comprises sodium sulfacetamide.

73. The method of claim 59 wherein the mites are of the genus Demodex.

74. The method of claim 59 wherein the carrier comprises an aqueous base.

75. The method of claim 59 wherein the composition comprises a high sorption base.

76. The method of claim 75 wherein the high sorption base comprises one or more of the group consisting of non-swelling clay, gum, swelling clay and silicon.

77. The method of claim 76 wherein the non-swelling clay comprises kaolin.

78. The method of claim 76 wherein the non-swelling clay is present at about 18.00%.

79. The method of claim 76 wherein the gum comprises xanthan gum.

80. The method of claim 76 wherein the gum is present at about 0.30%.

81. The method of claim 76 wherein the swelling clay comprises magnesium aluminum silicate.

82. The method of claim 76 wherein the swelling clay is present at about 1.50%.

83. The method of claim 76 wherein the silicon comprises silicon dioxide.

84. The method of claim 76 wherein the silicon is present at about 5.00%.

85. The method of claim 76 wherein the composition further comprises water.

86. The method of claim 85 wherein the water is present at about 40-50%.

58. A method for treatment of infestations of cutaneous mites comprising:

Applying a composition to skin, wherein the composition comprises a cleanser comprising about 5% sulfur, about 10% sodium sulfacetamide and a dermatologically acceptable carrier, the composition has a pH of about 6.5 to 8.1;

Washing and rewashing the composition from the skin.

59. A method for reducing skin inflammation relating to infestations of cutaneous mites comprising

Applying a composition to skin, wherein the composition comprises sulfur, one or more sulfur derivative and a dermatologically acceptable carrier.

66. The method of claims 59, 60 or 61 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1.

70. The method of claims 59, 60 or 61 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide.

71. The method of claim 68 wherein the sulfur derivative is present in the range of about 10%.

72. The method of claims 59, 60 or 61 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide present in the range of about 10% and wherein the sulfur is present in the range of about 5%.

87. A method for reducing skin inflammation relating to infestations of cutaneous mites comprising

Applying a composition to skin, wherein the composition comprises sulfur, one or more sulfur derivative and a dermatologically acceptable carrier.

88. The method of claim 87 further comprising washing the composition from the skin.

89. The method of claim 88 further comprising rewashing the composition from the skin.

90. The method of claim 87 wherein the composition comprises a cleanser.

91. The method of claim 87, 88 or 89 wherein the composition has a pH of about 7.0 to about 8.1.

92. The method of claim 87, 88 or 89 wherein the composition has a pH of about 7.7 to about 8.1.

93. The method of claim 87, 88 or 89 wherein the composition has a pH of about 7.3 to about 7.7.

94. The method of claims 87, 88 or 89 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1.

95. The method of claim 87 wherein the sulfur derivative comprises one or more cationic sulfur compounds.

96. The method of claim 87 wherein the sulfur derivative comprises one or more of the group consisting of selenium sulfide, potassium sulfide, poly-potassium sulfide, and poly-calcium poly-sulfide;

H₂S;

sulfuric acid;

bisulfides;

sulfur dioxide;

thiols;

organic salts;

sodium sulfacetamide;

sulfites; and

mercaptans.

97. The method of claim 87 wherein the sulfur derivative comprises sodium sulfacetamide.

98. The method of claims 87, 88 or 89 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide.

99. The method of claim 96 wherein the sulfur derivative is present in the range of about 10%.

100. The method of claims 87, 88 or 89 wherein the composition comprises a cleanser with a pH of 6.5 to 8.1 and wherein the sulfur derivative comprises sodium sulfacetamide present in the range of about 10% and wherein the sulfur is present in the range of about 5%.

101. The method of claim 87 wherein the mites are of the genus Demodex.

102. The method of claim 87 wherein the carrier comprises an aqueous base.

103. The method of claim 87 wherein the composition comprises a high sorption base.

104. The method of claim 103 wherein the high sorption base comprises one or more of the group consisting of non-swelling clay, gum, swelling clay and silicon.

105. The method of claim 103 wherein the non-swelling clay comprises kaolin.

106. The method of claim 103 wherein the non-swelling clay is present at about 18.00%.

107. The method of claim 103 wherein the gum comprises xanthan gum.

108. The method of claim 103 wherein the gum is present at about 0.30%.

109. The method of claim 103 wherein the swelling clay comprises magnesium aluminum silicate.

110. The method of claim 103 wherein the swelling clay is present at about 1.50%.

111. The method of claim 103 wherein the silicon comprises silicon dioxide.

112. The method of claim 103 wherein the silicon is present at about 5.00%.

113. The method of claim 103 wherein the composition further comprises water.

114. The method of claim 104 wherein the water is present at about 40-50%.

115. A method for prevention of infestations of cutaneous mites comprising:

Applying a composition to skin, wherein the composition comprises a cleanser comprising about 5% sulfur, about 10% sodium sulfacetamide and a dermatologically acceptable carrier, the composition has a pH of about 6.5 to 8.1;

Washing and rewashing the composition from the skin.