Method and product for accelerating absorption of medicaments through oral mucosa
First Claim
Patent Images
1. A coated chewing gum product with absorption acceleration of a medicament, comprising:
- a) a chewing gum center comprising a gum base, a flavor, and a bulking/sweetening agent;
b) a chewing gum coating comprising a polyol selected from the group consisting of xylitol and sorbitol, and containing at least one medicament; and
c) a bicarbonate salt incorporated into the chewing gum center, the coating, or both.
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Abstract
A method for producing a coated chewing gum product with accelerated absorption of medicaments through oral mucosa, as well as the chewing gum product so produced, is obtained by using a xylitol or sorbitol coating, or by adding a water-soluble alkaline material, such as a bicarbonate salt, to the chewing gum center, a coating on the center, or both. Coatings made with sorbitol or xylitol or gum centers that include sodium bicarbonate are particularly preferred.
109 Citations
39 Claims
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1. A coated chewing gum product with absorption acceleration of a medicament, comprising:
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a) a chewing gum center comprising a gum base, a flavor, and a bulking/sweetening agent;
b) a chewing gum coating comprising a polyol selected from the group consisting of xylitol and sorbitol, and containing at least one medicament; and
c) a bicarbonate salt incorporated into the chewing gum center, the coating, or both. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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16. A coated chewing gum product including a medicament comprising:
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a) a chewing gum center;
b) a chewing gum coating containing at least one medicament; and
c) a water-soluble alkaline material incorporated into the chewing gum center, the coating, or both.
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30. A method of delivering a medicament with accelerated absorption through the oral mucosa comprising the steps of:
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a) providing a chewing gum center;
b) coating the chewing gum center with a coating comprising a polyol selected from the group consisting of xylitol and sorbitol, and containing at least one medicament;
c) either the chewing gum center, the coating, or both incorporating a bicarbonate salt; and
d) causing an individual in need of the medicament to chew the product. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 39)
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38. A coated chewing gum product with absorption acceleration of caffeine, comprising:
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a) a chewing gum center comprising a gum base, a flavor, and a bulking/sweetening agent; and
b) a chewing gum coating comprising caffeine and a polyol selected from the group consisting of sorbitol and xylitol.
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Specification