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Tissue remodeling

  • US 20020165150A1
  • Filed: 12/31/2001
  • Published: 11/07/2002
  • Est. Priority Date: 09/25/1998
  • Status: Active Grant
First Claim
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1. A method for the modulation of tissue-remodeling, the method comprising:

  • contacting the tissue to be remodeled with an effective amount of a compound comprising a sequence selected from;

    (a) a sequence which is a continuous stretch of at least five amino acids present in a native TGFβ

    superfamily Ser/Thr kinase receptor, in positions of the receptor corresponding to positions 249 to 279 of TGFβ

    I receptor (HJ loop);

    (b) a sequence which is a continuous stretch of at least five amino acids present in a native TGFβ

    superfamily Ser/Thr kinase receptor, in positions of the receptor corresponding to positions 119 to 139 of TGFβ

    I receptor (α

    D region);

    (c) a sequence which is a continuous stretch of at least five amino acids present in a native TGFβ

    superfamily Ser/Thr kinase receptor, in positions of the receptor corresponding to positions 104 to 115 of TGFβ

    I receptor (B4-B5 region);

    (d) a sequence which is a continuous stretch of at least five amino acids present in a native TGFβ

    superfamily Ser/Thr kinase receptor, in positions of the receptor corresponding to positions 89 to 103 of TGFβ

    I (A-region);

    (e) a variant of a sequence according to any one of (a) to (d) wherein up to 40% of the amino acid of the native sequence have been replaced with a naturally or non-naturally occurring amino acid or with a peptidomimetic organic moiety; and

    /or up to 40% of the amino acids have their side chains chemically modified and/or up to 20% of the amino acids have been deleted;

    provided that at least 50% of the amino acids in the parent sequence of (a) to (d) are maintained unaltered in the variant, and provided that the variant maintains the biological activity of the parent sequences of (a) to (d);

    (f) a sequence of any one of (a) to (e) wherein at least one of the amino acids is replaced by the corresponding D-amino acid;

    (g) a sequence of any one of (a) to (f) wherein at least one of the peptidic backbones has been altered to a non-naturally occurring peptidic backbone;

    (h) a sequence being the sequence of any one of (a) to (g) in reverse order; and

    (i) a combination of two or more of the sequences of (a) to (h).

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