Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
First Claim
1. A nucleic acid molecule, comprising a sequence of nucleotides encoding a conjugate that comprises a toxin and a chemokine receptor targeting agent, or a portion thereof sufficient for binding to a chemokine receptor and internalization thereof, wherein the conjugate binds to a chemokine receptor resulting in internalization of the toxin in cells bearing the receptor.
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Accused Products
Abstract
Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune effector cells, including leukocyte cell types, neutrophils, macrophages, and eosinophils.
28 Citations
24 Claims
- 1. A nucleic acid molecule, comprising a sequence of nucleotides encoding a conjugate that comprises a toxin and a chemokine receptor targeting agent, or a portion thereof sufficient for binding to a chemokine receptor and internalization thereof, wherein the conjugate binds to a chemokine receptor resulting in internalization of the toxin in cells bearing the receptor.
Specification