Hormone replacement therapy
First Claim
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1. A method of treating or inhibiting menopausal or postmenopausal disorders in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
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Abstract
This invention relates to methods and pharmaceutical compositions for providing hormone replacement therapy in perimenopausal, menopausal, and postmenopausal women through the continuous administration of combinations of conjugated estrogens and medroxyprogesterone acetate.
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Citations
64 Claims
- 1. A method of treating or inhibiting menopausal or postmenopausal disorders in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
- 7. A method of treating or inhibiting vasomotor symptoms in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
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14. A method of inhibiting or retarding bone demineralization or treating or inhibiting osteoporosis in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
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19. A method of treating or inhibiting vaginal or vulvar atrophy;
- atrophic vaginitis;
vaginal dryness;
pruritus;
dyspareunia;
dysuria;
frequent urination;
urinary incontinence;
urinary tract infections in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
- atrophic vaginitis;
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24. A method of lowering cholesterol, Lp(a), or LDL levels;
- inhibiting or treating hypercholesteremia;
hyperlipidemia;
cardiovascular disease;
atherosclerosis;
peripheral vascular disease;
restenosis, vasospasm;
or inhibiting vascular wall damage from cellular events leading toward immune mediated vascular damage, in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
- inhibiting or treating hypercholesteremia;
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29. A method of treating or inhibiting free radical involvement in the development of cancers, central nervous system disorders, Alzheimer'"'"'s disease, bone disease, aging, inflammatory disorders, peripheral vascular disease, rheumatoid arthritis, autoimmune diseases, respiratory distress, emphysema, prevention of reperfusion injury, viral hepatitis, chronic active hepatitis, tuberculosis, psoriasis, systemic lupus erythematosus, amyotrophic lateral sclerosis, aging effects, adult respiratory distress syndrome, central nervous system trauma and stroke, or injury during reperfusion procedures in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
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34. A method of treating or inhibiting dementias, neurodegenerative disorders, and Alzheimer'"'"'s disease;
- providing neuroprotection or cognition enhancement in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
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39. A pharmaceutical composition for use in treating menopausal or postmenopausal disorders, which comprises dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate, and a pharmaceutical carrier.
- 44. A pharmaceutical dosage unit which comprises which comprises conjugated estrogens, a dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate, and a pharmaceutical carrier.
- 50. A method of minimizing or reducing levels of breast pain in a woman receiving hormone replacement therapy, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
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55. A method of minimizing spotting or breakthrough bleeding;
- or achieving amenorrhea in a woman receiving hormone replacement therapy, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
- View Dependent Claims (56, 57, 58, 59)
- 60. A method of increasing bone mineral density in a perimenopausal, menopausal, or postmenopausal woman in need thereof, which comprises orally providing to said woman continuously and uninterruptedly over the treatment period, a combination of a daily dosage of between about 0.25 mg and about 0.1 mg conjugated estrogens and a daily dosage of between about 2.5 mg and about 0.5 mg of medroxyprogesterone acetate.
Specification