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Therapeutic liposome composition and method of preparation

  • US 20020172711A1
  • Filed: 12/10/2001
  • Published: 11/21/2002
  • Est. Priority Date: 10/11/1996
  • Status: Active Grant
First Claim
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1. A liposome composition for fusion with a target membrane of a cell, liposome, or the like, comprising a suspension of liposomes designed for targeting to the target membrane, where each liposome contains a therapeutic agent entrapped in the liposomes, an outer liposome surface having a coating of chemically releasable hydrophilic polymer chains, and hydrophobic polymers on the liposome outer surface, said polymers being shielded by the hydrophilic polymer coating and exposed for fusion with said target membrane when the hydrophilic polymer coating is chemically released.

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