Adhesive delivery system

• US 20020173770A1
• Filed: 05/16/2001
• Published: 11/21/2002
• Est. Priority Date: 05/16/2001
• Status: Abandoned Application

• Current Assignee: St Jude Medical Incorporated (Abbott Laboratories)
• Original Assignee: St Jude Medical Incorporated (Abbott Laboratories)
• Inventors: Flory, Alan R., Ogle, Matthew F., Thome, Scott P.
• Application Number:
  US09/858,793
• Publication Number:
  US 20020173770A1
• Time in Patent Office: Days
• US Class Current: 604/537
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/8811 characterised by the introducer tip, i.e. the part inserted into or onto the bone
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61F 2/2409 Support rings therefor, e.g. for connecting valves to tissue annuloplasty rings A61F2/2442
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00

Abstract

An adhesive delivery system described herein includes a reservoir of flowable adhesive and a delivery conduit with one or more apertures following a pattern. The one or more apertures of the delivery conduit preferably follow a curve. A prosthesis can be formed including an attachment surface and an adhesive delivery conduit associated with the attachment surface. The adhesive delivery conduit has at least one aperture and a central lumen connected to the aperture. The adhesive delivery systems are useful for the formation of medical devices, the implantation of medical devices and for wound healing.

Claims

1. An adhesive delivery system comprising a delivery conduit with one or more apertures and a central lumen connecting with the one or more apertures, wherein the one or more apertures follow a pattern.

2. The adhesive delivery system of claim 1 wherein the one or more apertures follow a curve.

3. The adhesive delivery system of claim 2 wherein the curve is a closed curve.

4. The adhesive delivery system of claim 2 wherein the curve is planar.

5. The adhesive delivery system of claim 2 wherein the curve is non-planar.

6. The adhesive delivery system of claim 1 wherein the one or more apertures comprises a plurality of apertures.

7. The adhesive delivery system of claim 6 wherein the plurality of apertures comprise a circular aperture.

8. The adhesive delivery system of claim 1 wherein the one or more apertures comprise a slit.

9. The adhesive delivery system of claim 1 wherein the one or more apertures follow a straight line.

10. The adhesive delivery system of claim 1 wherein the delivery conduit comprises a plurality of apertures following a non-planar scalloped shape.

11. The adhesive delivery system of claim 1 wherein the delivery conduit comprises a plurality of apertures following a generally circular shape.

12. The adhesive delivery system of claim 1 further comprising an adhesive reservoir connected to the central lumen.

13. The adhesive delivery system of claim 12 further comprising a valve to control the release of adhesive from the reservoir to the delivery conduit.

14. The adhesive delivery system of claim 12 further comprising a syringe controlling flow from the adhesive reservoir to the delivery conduit.

15. The adhesive delivery system of claim 12 wherein the adhesive reservoir comprises a medical adhesive selected from the group consisting of a fibrin glue, a urethane polymer and a cyanoacrylate compound.

16. The adhesive delivery system of claim 1 further comprising a prosthesis attached to the delivery conduit.

17. The adhesive delivery system of claim 16 wherein an adhesive reservoir is incorporated into the prosthesis.

18. The adhesive delivery system of claim 1 further comprising a tubular prosthesis attached to the delivery conduit.

19. The adhesive delivery system of claim 1 further comprising a heart valve prosthesis attached to the delivery conduit.

20. The adhesive delivery system of claim 19 wherein the heart valve prosthesis is an aortic heart valve prosthesis.

21. The adhesive delivery system of claim 19 wherein the aortic heart valve prosthesis is stentless and wherein the delivery conduit comprises a plurality of apertures-following a scalloped shape extending near the outflow edge of the prosthesis.

22. The adhesive delivery system of claim 1 further comprising an annuloplasty ring attached to the delivery conduit.

23. The adhesive delivery system of claim 1 wherein the delivery conduit is releasably attached to an adhesive reservoir.

25. The prosthesis of claim 24 wherein the delivery conduit is curved.

26. The prosthesis of claim 24 wherein the prosthesis comprises a heart valve prosthesis.

27. The prosthesis of claim 24 wherein the adhesive delivery conduit is connected to an adhesive reservoir.

28. The prosthesis of claim 24 wherein the delivery conduit is attached to the prosthesis with suture, clips or hooks.

29. The prosthesis of claim 24 wherein the prosthesis comprises a stentless aortic heart valve prosthesis having a scalloped outflow edge and wherein the delivery conduit follows a closed curve near the scalloped outflow edge.

24. A prosthesis comprising an attachment surface and an adhesive delivery conduit associated with the attachment surface, the adhesive delivery conduit having at least one aperture and a central lumen connected to the aperture.

30. A method for preparing a prosthesis for implantation, the prosthesis comprising an attachment surface, the method comprising placing a delivery conduit with at least one aperture along the attachment surface.

31. The method of claim 30 wherein the prosthesis comprises a heart valve prosthesis.

32. The method of claim 30 wherein the delivery conduit comprises a perforated section following a closed curve.

33. The method of claim 30 wherein the placing of the delivery conduit comprises attachment of suture, hooks or clips around the delivery conduit.

34. The method of claim 30 wherein the delivery conduit is attached to an adhesive reservoir with a channel connecting the conduit and the adhesive reservoir and wherein flow control component controls the release of adhesive from the reservoir to the delivery conduit.

35. The method of claim 34 wherein the adhesive flow from the delivery conduit follows a curve with a continuous pattern.

36. The method of claim 35 wherein the adhesive flow from the delivery conduit follows a curve with an intermittent pattern.

38. The method of claim 37 wherein the delivery conduit delivers adhesive along a curve.

39. The method of claim 37 wherein adhesive components from two adhesive reservoirs are mixed prior to the delivery through the aperture.

40. The method of claim 37 wherein the composition comprises an adhesive component and wherein another adhesive component is applied through a second delivery conduit with at least one aperture.

37. A method for the implantation of a prosthesis comprising delivering a pattern of a composition selected from the group consisting of a medical adhesive, a medical adhesive component and treatment compound, through a delivery conduit comprising at least one aperture.

41. A method of making a medical device, the method comprising applying an adhesive through a delivery conduit and forming an adhesive bond with the adhesive connecting to prosthesis components.

42. An adhesive delivery system comprising an adhesive delivery conduit comprising a resorbable polymer.

43. The adhesive delivery system of claim 42 further comprising a metal support associated with the adhesive delivery conduit.

44. The adhesive delivery system of claim 42 wherein the resorbable polymer comprises D-polylactic acid, L-polylactic acid, poly(glycolic acid), and copolymers of at least two of L-lactic acid, D-lactic acid and glycolic acid.

45. The adhesive delivery system of claim 42 wherein the adhesive delivery conduit has one or more apertures following a pattern.

46. The adhesive delivery system of claim 45 wherein the one or more apertures follow a curve.

47. The adhesive delivery system of claim 45 wherein the one or more apertures comprise a plurality of apertures.

48. A prosthesis comprising an adhesive delivery system of claim 42.

49. The prosthesis of claim 48 comprising a heart valve prosthesis.

50. The prosthesis of claim 49 wherein the heart valve prosthesis is a stentless aortic heart valve prosthesis.

51. An adhesive delivery system comprising an adhesive delivery conduit having a plurality of microtentacles/microtubules extending from the surface of the adhesive delivery conduit.

52. The adhesive delivery conduit of claim 51 wherein the microtentacles/microtubules are fenestrated.

53. The adhesive delivery conduit of claim 51 wherein the microtentacles/microtubules are non-fenestrated.

54. The adhesive delivery conduit of claim 51 wherein the adhesive delivery conduit comprises one or more apertures following a pattern.

55. The adhesive delivery conduit of claim 54 wherein the one or more apertures follow a curve.