Remineralizaing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use
First Claim
1. A solid oral product capable of effecting remineralization of subsurface dental lesions and/or mineralization of exposed dentinal tubules, comprising:
- (A) a discrete cationic agglomerate component comprising at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component comprising at least one water-soluble orthophosphate salt and a second inert solid carrier;
wherein components (A) and (B) have a pH in water such that a mixed aqueous solution formed by mixing components (A) and (B) with water and/or saliva has a pH of from about 4.5 to about 10.0;
further wherein the cationic and anionic agglomerate components are simultaneously releasable from the product upon mixing of the product with water and/or saliva to form the mixed aqueous solution such that the mixed aqueous solution comprises calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt.
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Accused Products
Abstract
A solid oral product, e.g., chewing gum, lozenge, an edible foodstuff, and the like, which is useful for remineralizing subsurface dental lesions and/or mineralizing exposed dentinal tubules, contains (A) a discrete cationic agglomerate component composed of at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component composed of at least one water-soluble orthophosphate salt and a second inert solid carrier. The agglomerate nature of the cationic and anionic components keeps these components separate from one another during storage of the product but allows the cationic and anionic salts to be simultaneously released from the product upon mixing of the product with water and/or saliva to form a mixed aqueous solution such that the solution contains both calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt.
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Citations
26 Claims
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1. A solid oral product capable of effecting remineralization of subsurface dental lesions and/or mineralization of exposed dentinal tubules, comprising:
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(A) a discrete cationic agglomerate component comprising at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component comprising at least one water-soluble orthophosphate salt and a second inert solid carrier;
wherein components (A) and (B) have a pH in water such that a mixed aqueous solution formed by mixing components (A) and (B) with water and/or saliva has a pH of from about 4.5 to about 10.0;
further wherein the cationic and anionic agglomerate components are simultaneously releasable from the product upon mixing of the product with water and/or saliva to form the mixed aqueous solution such that the mixed aqueous solution comprises calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25, 26)
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23. A method for remineralizing at least one subsurface lesion in at least one tooth and/or mineralizing at least one exposed dentinal tubule in the at least one tooth, comprising the steps of:
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(1) providing a solid oral product comprising;
(A) a discrete cationic agglomerate component comprising at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component comprising at least one water-soluble orthophosphate salt and a second inert solid carrier;
wherein components (A) and (B) have a pH in water such that a mixed aqueous solution formed by mixing components (A) and (B) with water and/or saliva has a pH of from about 4.5 to about 10.0;
further wherein the cationic and anionic agglomerate components are simultaneously releasable from the product upon mixing of the product with water and/or saliva to form the mixed aqueous solution such that the mixed aqueous solution comprises calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt;
(2) contacting the product with water and/or saliva so as to form a mixed aqueous solution having a pH of from about 4.5 to about 10.0 and comprising calcium cations released by the calcium salt and orthophosphate ions released by the orthophosphate salt; and
(3) contacting the at least one tooth with the mixed aqueous solution for a period of time sufficient to allow a remineralizing/mineralizing amount of the calcium anions and a remineralizing/mineralizing amount of the orthophosphate anions to diffuse through the tooth to a subsurface thereof, wherein the diffused calcium cations and the diffused orthophosphate anions react together to form calcium hydroxyapatite onto the subsurface lesion and/or onto the exposed dentinal tubule, thereby remineralizing said lesion and/or mineralizing said exposed dentinal tubule.
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Specification