Monitoring analyte concentration using minimally invasive devices
First Claim
1. A method of monitoring the concentration of an analyte in a host or portion thereof over a given time period, said method comprising:
- (a) making a first analyte concentration measurement in said host or portion thereof at a first point in said time period using a first substantially painless single use analyte concentration measurement means;
(b) making a second analyte concentration measurement in said host or portion thereof at a second point in said time period using a second substantially painless single use analyte concentration measurement means; and
(c) optionally making one or more additional analyte concentration measurements during said time period using one or more additional substantially painless single use analyte concentration measurement means;
wherein said analyte concentration measurements are made according to a selected scheduling mode to monitor the concentration of said analyte in said host or portion thereof over said given time period.
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Accused Products
Abstract
Methods and devices are provided for “continuously”monitoring the concentration of an analyte in a host, i.e., for automatically measuring the concentration of an analyte at two or more points during a given time period. In the subject methods, substantially painless single use analyte concentration detection devices are employed to measure the concentration of the analyte of interest in the host, or portion thereof, e.g., interstitial fluid, where the measurements take place automatically according to a predetermined schedule. Devices provided by the subject methods have at least two different substantially painless single use analyte concentration measurement components which are under the control of a processing means that activates the measurement components according to a predetermined schedule. Also provided are systems and kits for use in practicing the subject methods. The subject methods find use in monitoring the concentration of a variety of different analytes of interest, and are particularly suited for use in monitoring the concentration of glucose.
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Citations
39 Claims
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1. A method of monitoring the concentration of an analyte in a host or portion thereof over a given time period, said method comprising:
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(a) making a first analyte concentration measurement in said host or portion thereof at a first point in said time period using a first substantially painless single use analyte concentration measurement means;
(b) making a second analyte concentration measurement in said host or portion thereof at a second point in said time period using a second substantially painless single use analyte concentration measurement means; and
(c) optionally making one or more additional analyte concentration measurements during said time period using one or more additional substantially painless single use analyte concentration measurement means;
wherein said analyte concentration measurements are made according to a selected scheduling mode to monitor the concentration of said analyte in said host or portion thereof over said given time period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, 20, 21)
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15. A method of monitoring the concentration of glucose in interstitial fluid of a host over a given time period, said method comprising:
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(a) making a first interstitial fluid glucose concentration measurement at a first point in said time period using a first substantially painless single use interstitial fluid glucose concentration measurement means;
(b) making a second interestitial fluid glucose concentration measurement at a second point in said time period using a second substantially painless single use interestitial fluid glucose concentration measurement means; and
(c) optionally making one or more additional interstitial fluid glucose concentration measurements during said time period using one or more additional substantially painless single use interestitial fluid glucose concentration measurement means;
wherein said interstitial fluid glucose concentration measurements are made according to a predetermined schedule to monitor the concentration of interstitial fluid glucose over said given time period.
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22. A device for using in monitoring the concentration of an analyte in a host or portion thereof over a given period of time, said device comprising:
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(a) at least a first and a second substantially painless single use analyte concentration measurement means; and
(b) an activation means for selectively activating said first and second analyte concentration measurement means according to a predetermined schedule. - View Dependent Claims (23, 24, 25, 26, 27, 29, 30, 31, 32)
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28. A system for use in monitoring the concentration of an analyte in a host or portion thereof over a given period of time, said system comprising:
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(a) a removable cartridge comprising at least a first and a second substantially painless single use analyte concentration measurement means; and
(b) a device into which said cartridge may be inserted, wherein said device comprises an activation means for selectively activating said first and second measurement means of said cartridge according to a predetermined schedule.
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33. A kit for use in monitoring the concentration of an analyte in a host or portion thereof over a given period of time, said kit comprising:
at least one of;
(a) a removable cartridge comprising at least a first and a second substantially painless single use analyte concentration measurement means; and
(b) a device into which said cartridge may be inserted, wherein said device comprises a an activation means for selectively activating said first and second measurement means of said cartridge according to a predetermined schedule. - View Dependent Claims (34, 35, 36, 37, 38, 39)
Specification