Central blood pressure waveform estimation device and peripheral blood pressure waveform detection device

• US 20020177781A1
• Filed: 04/17/2002
• Published: 11/28/2002
• Est. Priority Date: 04/19/2001
• Status: Active Grant

• Current Assignee: Seiko Epson Corporation (Seiko Group)
• Original Assignee: Seiko Epson Corporation (Seiko Group)
• Inventors: Amano, Kazuhiko
• Granted Patent: US 6,740,045 B2
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

A central blood pressure waveform estimation device has a pulse wave detection section, a transfer function storage section, and a central blood pressure waveform calculation section. The pulse wave detection section non-invasively detects a peripheral pulse wave. The transfer function storage section stores a transfer function calculated in advance based on a peripheral pulse waveform detected by the pulse wave detection section and a central blood pressure waveform invasively measured. The central blood pressure waveform calculation section calculates a central blood pressure waveform based on a peripheral pulse waveform newly detected by the pulse wave detection section and the transfer function stored in the transfer function storage section.

Claims

1. A central blood pressure waveform estimation device comprising:

a pulse wave detection section which non-invasively detects a peripheral pulse wave;

a transfer function storage section which stores a transfer function calculated in advance based on a waveform of the peripheral pulse wave detected by the pulse wave detection section and a central blood pressure waveform corresponding to the peripheral pulse waveform; and

a central blood pressure waveform calculation section which calculates a central blood pressure waveform corresponding to a waveform of a peripheral pulse wave newly detected by the pulse wave detection section, based on the newly-detected peripheral pulse waveform and the transfer function.

2. The central blood pressure waveform estimation device as defined in claim 1, further comprising:

a central blood pressure waveform index derivation section which derives an index from a central blood pressure waveform calculated by the central blood pressure waveform calculation section.

3. The central blood pressure waveform estimation device as defined in claim 2,

wherein the index derived by the central blood pressure waveform index derivation section is a pre-systolic blood pressure.

4. The central blood pressure waveform estimation device as defined in claim 2,

wherein the index derived by the central blood pressure waveform index derivation section is a post-systolic blood pressure.

5. The central blood pressure waveform estimation device as defined in claim 2,

wherein the index derived by the central blood pressure waveform index derivation section is a diastolic blood pressure.

6. The central blood pressure waveform estimation device as defined in claim 2,

wherein the index derived by the central blood pressure waveform index derivation section is a differential pressure between a post-systolic blood pressure and a blood pressure at a dicrotic notch.

7. The central blood pressure waveform estimation device as defined in claim 2,

wherein the index derived by the central blood pressure waveform index derivation section is a ratio of a post-systolic blood pressure to a blood pressure at the peak of a tidal wave.

8. The central blood pressure waveform estimation device as defined in claim 2, further comprising:

a central blood pressure waveform index storage section which stores the index of a central blood pressure waveform; and

a change analysis section which analyzes the change in the index of a central blood pressure waveform, based on an index newly derived by the central blood pressure waveform index derivation section and the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section.

9. The central blood pressure waveform estimation device as defined in claim 8,

wherein the change analysis section includes:

a basal central blood pressure waveform index derivation section which derives an index of a basal central blood pressure waveform, which is an index of a central blood pressure waveform when basal metabolism of a subject is in the lowest region in a predetermined period of time, from the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section; and

a basal central blood pressure waveform index storage section which stores the basal central blood pressure waveform index derived by the basal central blood pressure waveform index derivation section, and

wherein the change in the index of a central blood pressure waveform is analyzed, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and the basal central blood pressure waveform index stored in the basal central blood pressure waveform index storage section.

10. The central blood pressure waveform estimation device as defined in claim 2, further comprising:

a data input section to which an actual age of a subject is input; and

a comparative analysis section which compares and analyzes an index of a central blood pressure waveform, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and a standard index of a central blood pressure waveform at the actual age.

11. The central blood pressure waveform estimation device as defined in claim 1,

wherein the pulse wave detection section is formed to detect a plethysmogram which changes corresponding to the blood flow, as the change in the amount of erythrocytes in capillary vessels near the skin.

12. The central blood pressure waveform estimation device as defined in claim 1,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to a plurality of different states of a single subject.

13. The central blood pressure waveform estimation device as defined in claim 12,

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting one transfer function from the plurality of transfer functions based on information detected by the pulse wave detection section.

14. The central blood pressure waveform estimation device as defined in claim 1,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

15. The central blood pressure waveform estimation device as defined in claim 1,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different physiological ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the physiological age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

17. The central blood pressure waveform estimation device as defined in claim 16, further comprising:

a central blood pressure waveform index derivation section which derives an index from a central blood pressure waveform calculated by the central blood pressure waveform calculation section.

18. The central blood pressure waveform estimation device as defined in claim 17, further comprising:

a central blood pressure waveform index storage section which stores the index of the central blood pressure waveform; and

a change analysis section which analyzes the change in the index of the central blood pressure waveform, based on an index newly derived by the central blood pressure waveform index derivation section and the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section.

19. The central blood pressure waveform estimation device as defined in claim 18,

wherein the change analysis section includes:

a basal central blood pressure waveform index derivation section which derives an index of the basal central blood pressure waveform, which is an index of the central blood pressure waveform when basal metabolism of a subject is in the lowest region in a predetermined period of time, from the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section; and

a basal central blood pressure waveform index storage section which stores the basal central blood pressure waveform index derived by the basal central blood pressure waveform index derivation section, and

wherein the change in the index of a central blood pressure waveform is analyzed, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and the basal central blood pressure waveform index stored in the basal central blood pressure waveform index storage section.

20. The central blood pressure waveform estimation device as defined in claim 17, further comprising:

a data input section to which the actual age of a subject is input; and

a comparative analysis section which compares and analyzes an index of a central blood pressure waveform, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and a standard index of a central blood pressure waveform at the actual age.

21. The central blood pressure waveform estimation device as defined in claim 16,

wherein the pulse wave detection section is formed to detect a plethysmogram which changes corresponding to the blood flow, as the change in the amount of erythrocytes in capillary vessels near the skin.

22. The central blood pressure waveform estimation device as defined in claim 16,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to a plurality of different states of a single subject.

23. The central blood pressure waveform estimation device as defined in claim 22,

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting one transfer function from the plurality of transfer functions based on information detected by the pulse wave detection section.

24. The central blood pressure waveform estimation device as defined in claim 16,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

25. The central blood pressure waveform estimation device as defined in claim 16,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different physiological ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the physiological age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

27. The central blood pressure waveform estimation device as defined in claim 26, further comprising:

a central blood pressure waveform index derivation section which derives an index from a central blood pressure waveform calculated by the central blood pressure waveform calculation section.

28. The central blood pressure waveform estimation device as defined in claim 27, further comprising:

a central blood pressure waveform index storage section which stores the index of the central blood pressure waveform; and

a change analysis section which analyzes the change in the index of the central blood pressure waveform, based on an index newly derived by the central blood pressure waveform index derivation section and the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section.

29. The central blood pressure waveform estimation device as defined in claim 28,

wherein the change analysis section includes:

a basal central blood pressure waveform index derivation section which derives an index of the basal central blood pressure waveform, which is an index of the central blood pressure waveform when basal metabolism of a subject is in the lowest region in a predetermined period of time, from the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section; and

a basal central blood pressure waveform index storage section which stores the basal central blood pressure waveform index derived by the basal central blood pressure waveform index derivation section, and

wherein the change in the index of a central blood pressure waveform is analyzed, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and the basal central blood pressure waveform index stored in the basal central blood pressure waveform index storage section.

30. The central blood pressure waveform estimation device as defined in claim 27, further comprising:

a data input section to which the actual age of a subject is input; and

a comparative analysis section which compares and analyzes an index of a central blood pressure waveform, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and a standard index of a central blood pressure waveform at the actual age.

31. The central blood pressure waveform estimation device as defined in claim 26,

wherein the pulse wave detection section is formed to detect a plethysmogram which changes corresponding to the blood flow, as the change in the amount of erythrocytes in capillary vessels near the skin.

32. The central blood pressure waveform estimation device as defined in claim 26,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to a plurality of different states of a single subject.

33. The central blood pressure waveform estimation device as defined in claim 32,

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting one transfer function from the plurality of transfer functions based on information detected by the pulse wave detection section.

34. The central blood pressure waveform estimation device as defined in claim 26,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

35. The central blood pressure waveform estimation device as defined in claim 26,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different physiological ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the physiological age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

37. The central blood pressure waveform estimation device as defined in claim 36, further comprising:

a central blood pressure waveform index derivation section which derives an index from a central blood pressure waveform calculated by the central blood pressure waveform calculation section.

38. The central blood pressure waveform estimation device as defined in claim 37, further comprising:

a central blood pressure waveform index storage section which stores the index of the central blood pressure waveform; and

a change analysis section which analyzes the change in the index of the central blood pressure waveform, based on an index newly derived by the central blood pressure waveform index derivation section and the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section.

39. The central blood pressure waveform estimation device as defined in claim 38,

wherein the change analysis section includes:

a basal central blood pressure waveform index derivation section which derives an index of the basal central blood pressure waveform, which is an index of the central blood pressure waveform when basal metabolism of a subject is in the lowest region in a predetermined period of time, from the index of the central blood pressure waveform stored in the central blood pressure waveform index storage section; and

a basal central blood pressure waveform index storage section which stores the basal central blood pressure waveform index derived by the basal central blood pressure waveform index derivation section, and

wherein the change in the index of a central blood pressure waveform is analyzed, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and the basal central blood pressure waveform index stored in the basal central blood pressure waveform index storage section.

40. The central blood pressure waveform estimation device as defined in claim 37, further comprising:

a data input section to which the actual age of a subject is input; and

a comparative analysis section which compares and analyzes an index of a central blood pressure waveform, based on the index of the central blood pressure waveform derived by the central blood pressure waveform index derivation section and a standard index of a central blood pressure waveform at the actual age.

41. The central blood pressure waveform estimation device as defined in claim 36,

wherein the pulse wave detection section is formed to detect a plethysmogram which changes corresponding to the blood flow, as the change in the amount of erythrocytes in capillary vessels near the skin.

42. The central blood pressure waveform estimation device as defined in claim 36,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to a plurality of different states of a single subject.

43. The central blood pressure waveform estimation device as defined in claim 42,

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting one transfer function from the plurality of transfer functions based on information detected by the pulse wave detection section.

44. The central blood pressure waveform estimation device as defined in claim 42,

wherein the blood pressure value storage section stores a plurality of blood pressure values corresponding to a plurality of different states of a single subject.

45. The central blood pressure waveform estimation device as defined in claim 44,

wherein the conversion section reads a blood pressure value selected from the plurality of blood pressure values stored in the blood pressure value storage section, based on information from the pulse wave detection section.

46. The central blood pressure waveform estimation device as defined in claim 44, further comprising:

an input section to which a state of a subject is input,

wherein the conversion section reads a blood pressure value selected from the plurality of blood pressure values stored in the blood pressure value storage section, based on information from the input section.

47. The central blood pressure waveform estimation device as defined in claim 36,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

48. The central blood pressure waveform estimation device as defined in claim 36,

wherein the transfer function storage section stores a plurality of transfer functions corresponding to different physiological ages;

and

wherein the central blood pressure waveform calculation section calculates a central blood pressure waveform by selecting a transfer function corresponding to the physiological age of a subject whose pulse wave is detected by the pulse wave detection section, from the plurality of transfer functions.

50. The peripheral blood pressure waveform detection device as defined in claim 49,

wherein the pulse wave detected by the pulse wave detection section is a plethysmogram which changes corresponding to the blood flow.

16. A central blood pressure waveform estimation device comprising:

a pulse wave detection section which non-invasively detects a peripheral pulse wave;

a transfer function storage section which stores a transfer function calculated in advance based on a waveform of the peripheral pulse wave detected previously and a central blood pressure waveform corresponding to the peripheral pulse waveform; and

a central blood pressure waveform calculation section which calculates a central blood pressure waveform corresponding to a waveform of a peripheral pulse wave newly detected by the pulse wave detection section, based on the newly-detected peripheral pulse waveform and the transfer function.

26. A central blood pressure waveform estimation device comprising:

a pulse wave detection section which non-invasively detects a peripheral pulse wave;

a blood pressure measurement section which measures a blood pressure in an area near a portion in which a peripheral pulse wave is detected by the pulse wave detection section;

a conversion section which converts a waveform of the peripheral pulse wave detected by the pulse wave detection section into a peripheral blood pressure waveform using a value of the blood pressure measured by the blood pressure measurement section;

a transfer function storage section which stores a transfer function calculated in advance based on the peripheral blood pressure waveform obtained by the conversion section and a central blood pressure waveform corresponding to the peripheral blood pressure waveform; and

a central blood pressure waveform calculation section which calculates a central blood pressure waveform corresponding to a peripheral blood pressure waveform obtained by converting a waveform of a pulse wave newly detected by the pulse wave detection section using the conversion section, based on the peripheral blood pressure waveform and the transfer function.

36. A central blood pressure waveform estimation device comprising:

a pulse wave detection section which non-invasively detects a peripheral pulse wave;

a blood pressure value storage section which stores a value of a blood pressure measured previously in an area near a portion in which a peripheral pulse wave is detected by the pulse wave detection section;

a conversion section which converts a waveform of the peripheral pulse wave detected by the pulse wave detection section into a peripheral blood pressure waveform using the blood pressure value stored in the blood pressure value storage section;

a transfer function storage section which stores a transfer function calculated in advance based on the peripheral blood pressure waveform obtained by the conversion section and a central blood pressure waveform corresponding to the peripheral blood pressure waveform; and

a central blood pressure waveform calculation section which calculates a central blood pressure waveform corresponding to a peripheral blood pressure waveform obtained by converting a waveform of a pulse wave newly detected by the pulse wave detection section using the conversion section, based on the peripheral blood pressure waveform and the transfer function.

49. A peripheral blood pressure waveform detection device comprising:

a pulse wave detection section which non-invasively detects a peripheral pulse wave;

a blood pressure measurement section which measures a blood pressure in an area near a portion in which a peripheral pulse wave is detected by the pulse wave detection section; and

a conversion section which converts a waveform of the peripheral pulse wave detected by the pulse wave detection section into a peripheral blood pressure waveform using a value of the blood pressure measured by the blood pressure measurement section.

51. A peripheral blood pressure waveform detection device comprising:

a pulse wave detection section which non-invasively detects a peripheral pulse wave;

a blood pressure value storage section which stores a value of a blood pressure measured previously in an area near a portion in which a peripheral pulse wave is detected by the pulse wave detection section; and

a conversion section which converts a waveform of the peripheral pulse wave detected by the pulse wave detection section into a peripheral blood pressure waveform using the blood pressure value stored in the blood pressure value storage section.

52. The peripheral blood pressure waveform detection device as defined in claim 51,

wherein the pulse wave detected by the pulse wave detection section is a plethysmogram which changes corresponding to the blood flow.

53. The peripheral blood pressure waveform detection device as defined in claim 51,

wherein the blood pressure value storage section stores a plurality of blood pressure values corresponding to a plurality of different states of a single subject.

54. The peripheral blood pressure waveform detection device as defined in claim 53,

wherein the conversion section reads a blood pressure value selected from the plurality of blood pressure values stored in the blood pressure value storage section, based on information from the pulse wave detection section.

55. The peripheral blood pressure waveform detection device as defined in claim 53, further comprising:

an input section to which a state of a subject is input,

wherein the conversion section reads a blood pressure value selected from the plurality of blood pressure values stored in the blood pressure value storage section, based on information from the input section.