Super-oxidized water, preparation and use thereof as sterilizers and medicaments

• US 20020182262A1
• Filed: 02/25/2002
• Published: 12/05/2002
• Est. Priority Date: 08/23/1999
• Status: Abandoned Application

• Current Assignee: Sterilox Medical Limited
• Original Assignee: Sterilox Medical Limited
• Inventors: Selkon, Joe B.
• Application Number:
  US10/084,518
• Publication Number:
  US 20020182262A1
• Time in Patent Office: Days
• US Class Current: 424/600
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C02F 1/4674 with halogen or compound of halogens, e.g. chlorine, bromine
• CPC Class Codes: C02F 2103/026 Treating water for medical or cosmetic purposes
• CPC Class Codes: C02F 2209/04 Oxidation reduction potential [ORP]
• CPC Class Codes: C02F 2209/06 pH
• CPC Class Codes: C02F 2303/04 Disinfection

Abstract

Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has a redox potential of >950 mV. Medicaments based on the super-oxidized water may be in liquid or gel form. The super-oxidized water is able to control the microbial population within the wound and at the same time permit cell proliferation.

Claims

1. A medicament for the treatment of open wounds, the medicament comprising super-oxidized water based on hypochlorous acid.

2. The medicament according to claim 1, wherein the super-oxidized water is in liquid form for application to the wound by bathing or spraying.

3. The medicament according to claim 1, wherein the super-oxidized water is in gel form for topical application to the wound.

4. The medicament according to claim 1, wherein the super-oxidized water or a preparation derived therefrom has a pH of 4 to 7.

5. The medicament according to claim 4, wherein the pH is in a range of about 4.0 to 6.5.

6. The medicament according to claim 5, wherein the pH is in a range of about 4.0 to 6.2.

7. The medicament according to claim 6, wherein the pH is in a range of about 4.3 to 6.2.

8. The medicament according to claim 7, wherein the pH is about 5.4.

9. The medicament according to claim 1, wherein the super-oxidized water has a redox potential of >

950 mV.

10. The medicament according to claim 9, wherein the super-oxidized water has a redox potential of about 1000 mV.

11. The medicament according to claim 1, wherein the super-oxidized water or a preparation derived therefrom has a biocide rate (D Value) of approximately 1 log reduction unit of bacillus subtilis spores in less than 1 minute with a 9:

1 super-oxidized water;

innoculum mix.

12. The medicament according to claim 1, wherein the super-oxidized water is diluted to an extent that it does not inhibit cell proliferation in use.

13. The medicament according to claim 12, wherein the super-oxidized water is diluted to an extent that it promotes cell proliferation in use.

14. The medicament according to claim 1, wherein the super-oxidized water comprises an output solution obtained by electrochemical treatment of a saline solution.

15. The medicament according to claim 14, wherein the super-oxidized water has a pH adjusted to a desired level by using an alkaline solution output from an electrochemical cell in which the saline solution is treated.

16. The medicament according to claim 14, wherein the output solution further comprises a phosphate buffer to adjust a pH of the solution to a desired level.

18. The super-oxidized water according to claim 17 having a pH of 4 to 7.

19. The super-oxidized water according to claim 18 having a pH in a range of about 4.0 to 6.5.

20. The super-oxidized water according to claim 19 having a pH in a range of about 4.0 to 6.2.

21. The super-oxidized water according to claim 20 having a pH in a range of about 4.3 to 6.2.

22. The super-oxidized water according to claim 21 having a pH of about 5.4.

23. The super-oxidized water according to claim 17, having a redox potential of >

950 mV.

24. The super-oxidized water according to claim 23 having a redox potential of about 1000 mV.

25. The super-oxidized water according to claim 17, having a biocide rate (D Value) of approximately 1 log unit reduction of bacillus subtilis spores in less than 1 minute with a 9:

1 super-oxidized water;

innoculum mix.

27. The method according to claim 26, comprising administering super-oxidized water as a medicament for treatment of leg ulcers or other open wounds.

28. The method according to claim 26, comprising administering the super-oxidized water as a medicament for controlling microbial population and permitting cell growth.

29. The method according to claim 26, wherein the super-oxidized water or a preparation derived therefrom has a pH of 4 to 7, a redox potential of >

950 mV, and a biocide rate (D Value) of approximately 1 log unit reduction of bacillus subtilis spores in less than 1 minute with a 9;

1 super-oxidized water;

innoculum mi.

30. A method of preparing a medicament according to 1, comprising passing a saline solution through an electrochemical cell having electrodes separated by a semipermeable membrane, operating the cell in such manner as to produce super-oxidized water based on hypochlorous acid, and incorporating the super-oxidized water in a carrier preparation at a sufficient concentration to impart biocidal properties and allow cell proliferation when applied to a human or animal body.

31. The method according to claim 30, further comprising controlling a pH of the super-oxidized water generated in the cell by a buffering action within the cell involving re-feeding alkaline solution also generated in the cell.

32. A method of treating a leg ulcer or other open wound on a human or animal body, comprising applying to the wound a medicament according to claim 1.

33. The method according to claim 32, wherein the step of applying the medicament comprises immersing the wound in a hydrobath containing the medicament.

17. A super-oxidized water based on hypochlorous acid for use in treatment of a human or animal body.

26. A method for treatment of a human or animal body, comprising administering to the human or animal body a super-oxidized water based on hypochlorous acid.

34. A hydrobath preparation for the treatment of leg ulcers or other open wounds comprising super-oxidized water based on hypochlorous acid.