Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
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Abstract
The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I:
or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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Citations
13 Claims
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1. A compound of Formula I:
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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2. A compound according to claim 1, wherein the compound is selected from the group:
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3. A compound according to claim 2, wherein the compound is selected from the group:
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4. A compound according to claim 3, wherein the compound is selected from the group:
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5. A compound according to claim 4, wherein:
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G is selected from;
A is selected from phenyl, piperidinyl, pyridyl, and pyrimidyl, and is substituted with 0-2 R4; and
,B is selected from phenyl, pyrrolidino, N-pyrrolidino-carbonyl, morpholino, N-morpholino-carbonyl, 1,2,3-triazolyl, imidazolyl, and benzimidazolyl, and is substituted with 0-1 R4a;
R2, at each occurrence, is selected from H, CH3, CH2CH3, cyclopropylmethyl, cyclobutyl, and cyclopentyl;
R2a, at each occurrence, is H or CH3, and CH2CH3;
alternatively, R2 and R2a, together with the atom to which they are attached, combine to form pyrrolidine substituted with 0-2 R4b or piperidine substituted with 0-2 R4b;
R4, at each occurrence, is selected from H, OH, OR2, (CH2)OR2, (CH2)2OR2, F, Br, Cl, I, C1-4 alkyl, NR2R2a, (CH2)NR2R2a, (CH2)2NR2R2a, CF3, and (CF2)CF3;
R4a is selected from H, C1-4 alkyl, CF3, OR2, (CH2)OR2, (CH2)2OR2, NR2R2a, (CH2)NR2R2a, (CH2)2NR2R2a, SR5, S(O)R5, S(O)2R5, SO2NR2R2a, and 1-CF3-tetrazol-2-yl;
R2b, at each occurrence, is selected from H, CH3, and OH;
R5, at each occurrence, is selected from CF3, C1-6 alkyl, phenyl, and benzyl; and
,r, at each occurrence, is selected from 0, 1, and 2.
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6. A compound according to claim 5, wherein:
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A is selected from the group;
phenyl, piperidinyl, 2-pyridyl, 3-pyridyl, 2-pyrimidyl, 2-Cl-phenyl, 3-Cl-phenyl, 2-F-phenyl, 3-F-phenyl, 2-methylphenyl, 2-aminophenyl, and 2-methoxyphenyl; and
,B is selected from the group;
2-(aminosulfonyl)phenyl, 2-(methylaminosulfonyl)phenyl, 1-pyrrolidinocarbonyl, 2-(methylsulfonyl)phenyl, 2-(N,N-dimethylaminomethyl)phenyl, 2-(N,N-diethylaminomethyl)phenyl, 2-(N-methylaminomethyl)phenyl, 2-(N-ethyl-N-methylaminomethyl)phenyl, 2-(N-pyrrolidinylmethyl)phenyl, 1-methyl-2-imidazolyl, 2-methyl-1-imidazolyl, 2-(dimethylaminomethyl)-1-imidazolyl, 2-(methylaminomethyl)-1-imidazolyl, 2-(N-(cyclopropylmethyl)aminomethyl)phenyl, 2-(N-(cyclobutyl)aminomethyl)phenyl, 2-(N-(cyclopentyl)aminomethyl)phenyl, 2-(N-(4-hydroxypiperidinyl)methyl)phenyl, 2-(N-(3-hydroxypyrrolidinyl)methyl)phenyl, and 2-(N-(2-hydroxyethyl)methylamino)-methyl)phenyl.
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7. A compound according to claim 1, wherein the compound is selected from the group:
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3-({1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)benzonitrile;
3-({1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)benzene-carboximidamide;
4-({1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)benzene-carboximidamide;
3-({1-[2-[(dimethylamino)methyl]-3-fluoro-[1,1′
-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)benzonitrile;
3-({1-[2-[(dimethylamino)methyl]-3-fluoro-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)benzene-carboximidamide;
3-({1-[2′
-[(dimethylamino)methyl]-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)benzene-carboximidamide;
3-({1-[2-[(dimethylamino)methyl]-3-fluoro-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}amino)benzene-carboximidamide;
2,4-dichloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}benzamide;
3-chloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-N-methyl-benzamide;
3,4-dichloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-benzamide;
4-fluoro-N-{1-[3-fluoro-2-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-benzamide;
4-chloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-benzamide;
2-chloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-isonicotinamide;
6-chloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-nicotinamide;
N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl]-6-(1H-pyrazol-1-yl)nicotinamide;
1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-2-chloronicotinate;
1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl4-methoxybenzoate;
2-({1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)-5-methoxybenzaldehyde;
3-[{5-chloro-2-pyridynyl)amino]-1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-piperidinone;
1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-3(4-methoxyphenoxy)-2-piperidinone;
2-({1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}oxy)-5-methoxybenzoate;
3-[3-(aminomethyl)phenoxy]-1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-piperidinone;
3-{[2-(anilinomethyl)-4-methoxyphenyl]oxo}-1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-piperidinone;
3-chloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-benzamide;
N-benzyl-4-chloro-N-{1-[3-fluoro-2′
-(methylsulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-benzamide;
N-{1-[3-fluoro-2′
-(methylthio)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-1H-indole-5-carboxamide;
N-{1-[3-fluoro-2′
-(methylthio)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-1H-pyrazole-4-carboxamide;
N-{1-[3-fluoro-2′
-(methylthio)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-isonicotinamide;
N-{1-[3-fluoro-2′
-(methylthio)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-nicotinamide;
6-amino-N-{1-[3-fluoro-2′
-(methylthio)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl]-nicotinamide;
6-amino-N-{1-[3-fluoro-2′
-(methylthio)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}-nicotinamide;
3-{[{1-[2′
-aminosulfonyl-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}(benzyl)amino]sulfonyl}-benzenecarboximidamide;
3-{[1-(3-fluoro-2′
-aminosulfonyl)-[1,1′
]-biphenyl-4-yl]-2-oxo-3-piperidinyl}(benzyl)amino]sulfonyl}benzenecarboximidamide;
3-{N-benzyl-N-[2-oxo-1-(2′
-sulfamoyl-biphenyl-4-yl)-piperidin-3-yl]-sulfamoyl}-benzamidine;
4-chloro-N-[1-3-fluoro-1-(2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
6-chloro-N-[1-(3-fluoro-2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-naphthalene-2-sulfonamide;
7-chloro-N-[1-(3-fluoro-2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-naphthalene-2-sulfonamide;
5-chloro-N-[1-(3-fluoro-2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
5-(3-isoxazolyl)-[1-3-fluoro-(2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
4-fluoro-N-[1-(3-fluoro-1-2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
N-[1-(3-fluoro-1-2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-4-methoxyl-benzenesulfonamide;
4-ethyl-N-[1-(3-fluoro-1-2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
N-[3-fluoro-1-(2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-3-methoxyl-benzenesulfonamide;
5-bromo-6-chloro-[3-fluoro-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-pyridine-3-sulfonamide;
5-(2-pyridyl)-[3-fluoro-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
3,4-difluoro-N-[3-fluoro-1-(2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
3-chloro-N-[3-fluoro-1-(2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
3,5-dichloro-[3-fluoro-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
3-cyano-N-[3-fluoro-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
3-chloro-4-fluoro-N-[3-fluoro-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide1-methyl-[3-fluoro-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-imidazole-4-sulfonamide;
2,5-dichloro-N-[3-fluoro-1-(2 ′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
3,5-dichloro-N-[3-fluoro-1-(2′
-methylsulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
5-chloro-N-[1-(2′
-diethylaminomethyl-3-fluoro-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
5-chloro-N-[1-(3-fluoro-1-2′
-pyrrolidin-1-ylmethyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
5-chloro-N-[1-(3-fluoro-1-2′
-(3-hydroxypyrrolidin-1-ylmethyl)-biphenyl -4-yl]-2-oxo-piperidin-3-yl}-thiophene-2-sulfonamide;
5-chloro-N-{1-[3-fluoro-1-2′
-(4-hydroxypiperidin-1-ylmethyl)-biphenyl-4-yl]-2-oxo-piperidin-3-yl}-thiophene-2-sulfonamide;
N-benzyl-5-chloro-N-[1-(2′
-diethylaminomethyl-3-fluoro-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
N-benzyl-5-chloro-N-[1-(3-fluoro-1-2′
-pyrrolidin-1-ylmethyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
N-benzyl-5-chloro-N-{1-[3-fluoro-1-2′
-(3-hydroxypyrrolidin-1-ylmethyl)-biphenyl-4-yl]-2-oxo-piperidin-3-yl}-thiophene-2-sulfonamide;
N-benzyl-5-chloro-N-{1-[3-fluoro-1-2′
-(4-hydroxypiperidin-1-ylmethyl)-biphenyl-4-yl]-2-oxo-piperidin-3-yl}-thiophene-2-sulfonamide;
5-chloro-[3-fluoro-1-(2′
-{[(2-hydroxy-ethyl)-methyl-amino]-methyl}-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-thiophene-2-sulfonamide;
3-amino-N-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzo[d]isoxazole-5-sulfonamide;
3-(3-amino-benzo[d]isoxazol-5-ylamino)-1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-piperidin-2-one;
2-fluoro-5-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-ylamino]-N-hydroxy-benzamidine;
1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-3-[3-(5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-phenylamino]-piperidin-2-one;
N-benzyl-4-chloro-N-[1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
4-chloro-N-methyl-N-[1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
4-chloro-N-ethyl-N-[1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
4-chloro-N-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-N-(3-pyridylmethyl)-benzenesulfonamide;
4-chloro-N-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-N-(2-pyridylmethyl)-benzenesulfonamide;
3-[[1,2-dihydro-1-[2′
-(methylsulfonyl)[1,1′
-biphenyl]-4-yl]-2-oxo-3-pyridinyl]amino]-benzenecarboximidamide;
3-[(4-methoxyphenyl)amino]-1-[2′
-(methylsulfonyl)[1,1′
-biphenyl]-4-yl]-2(1H)-pyridinone;
N-[1,2-dihydro-1-[2′
-(methylsulfonyl)[1,1′
-biphenyl]-4-yl]-2-oxo-3-pyridinyl]-4-methoxy-benzamide;
6-chloro-N-[1,2-dihydro-1-[2′
-(methylsulfonyl)[1,1′
-biphenyl]-4-yl]-2-oxo-3-pyridinyl]-3-pyridinecarboxamide;
3-[[1,2-dihydro-1-[2′
-[(3-hydroxy-1-pyrrolidinyl)methyl][1,1′
-biphenyl]-4-yl]-2-oxo-4-(1-pyrrolidinyl)-3-pyridinyl]amino]-benzenecarboximidamide;
3-[[1,2-dihydro-1-[2′
-[(3-hydroxy-1-pyrrolidinyl)methyl][1,1′
-biphenyl]-4-yl]-2-oxo-4-(1-pyrrolidinyl)-3-pyridinyl]amino]-benzamide;
3-[3-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-tetrahydro-pyrimidin-1-ylmethyl]-benzamidine;
4-benzyloxycarbonyl-3-(4-chlorobenzenesulfonylamino)-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperazine;
4-benzyloxycarbonyl-3-(4-methoxybenzenesulfonylamino)-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperazine;
5-chloro-[2-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]-thiophene-2-sulfonamide;
3-[1-(2′
-dimethylaminomethyl-biphenyl-4-yl)-2-oxo-azepan-3-ylamino]-benzamidine;
N-[3-benzyl-1-(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-4-chlorobenzamide;
[3-(6-chloro-naphthalene-2-sulfonylamino)-1(2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-acetic acid methyl ester;
N-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-3-(5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-benzenesulfonamide;
1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-3-[3-(5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-phenoxy]-piperidin-2-one;
[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-benzenesulfonamide;
[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-pyridin-3-yl-sulfonamide;
5-chloro-3-methyl-N-{1-[3-fluoro-1-2′
-(4-hydroxypiperidin-1-ylmethyl)-biphenyl-4-yl]-2-oxo-piperidin-3-yl}-thiophene-2-sulfonamide;
[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-quinolin-3-yl-sulfonamide;
[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-quinolin-6-yl-sulfonamide;
[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-quinoxalin-6-yl-sulfonamide;
[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-(6-amino-pyridin-3-yl)-sulfonamide;
[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-indazol-6-yl-sulfonamide;
6-chloronaphthalene-2-sulfonic acid [1-benzyl-4-(2′
-dimethylaminomethylbiphenyl-4-yl)-5-oxo-[1,4]-diazepan-6-yl]amide;
5-chloro-N-{1-[2′
-(methylsulfonyl)-1,1′
-biphenyl-4-yl]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl}-2-thiophenesulfonamide;
{(6-chloro-naphthalene-2-sulfonyl)-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-amino}-acetic acid methyl ester;
{(6-chloro-naphthalene-2-sulfonyl)-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-amino}-acetic acid ethyl ester;
{(6-chloro-naphthalene-2-sulfonyl)-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-amino}-acetic acid t-butyl ester;
6-chloro-naphthalene-2-sulfonic acid benzoyl-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-amide;
{(6-chloro-naphthalene-2-sulfonyl)-[1-(3-fluoro-2′
-methanesulfonylbiphenyl-4-yl)-2-oxo-piperidin-3-yl]amino}acetic acid;
2-{(6-chloronaphthalene-2-sulfonyl)-[1-(3-fluoro-2′
-methanesulfonylbiphenyl-4-yl)-2-oxo-piperidin-3-yl]-amino}-N-(2-dimethylaminoethyl)-N-methylacetamide;
2-{(6-Chloro-naphthalene-2-sulfonyl)-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-amino}-N-(2-hydroxy-ethyl)-acetamide; and
2-{(6-Chloro-naphthalene-2-sulfonyl)-[1-(3-fluoro-2′
-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-yl]-amino}-N-(2-dimethylamino-ethyl)-acetamide;
or a pharmaceutically acceptable salt form thereof.
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8. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
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9. A method for treating a thromboembolic disorder, comprising:
- administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
-
10. A method of treating a patient in need of thromboembolic disorder treatment, comprising:
- administering a compound of claim 1 or a pharmaceutically acceptable salt form thereof in an amount effective to treat a thromboembolic disorder
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11. A method, comprising:
- administering a compound of claim 1 or a pharmaceutically acceptable salt form thereof in an amount effective to treat a thromboembolic disorder.
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12. A compound of claim 1 for use in therapy.
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13. Use of a compound of claim 1 for the manufacture of a medicament for the treatment of a thromboembolic disorder.
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2. A compound according to claim 1, wherein the compound is selected from the group:
Specification
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Current AssigneeBristol-Myers Squibb Company, Bristol-Myers Squibb Pharma Company (Bristol-Myers Squibb Company)
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Original AssigneeBristol-Myers Squibb Pharma Company (Bristol-Myers Squibb Company)
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InventorsNakajima, Suanne, Qiao, Jennifer, Quan, Mimi L., Smallheer, Joanne M., Wang, Shuaige, Wexler, Ruth R., Jacobson, Irina C.
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current514/247
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CPC Class CodesA61P 43/00 Drugs for specific purposes...A61P 7/02 Antithrombotic agents; Anti...C07D 211/76 attached in position 2 or 6C07D 223/10 attached in position 2C07D 239/10 Oxygen or sulfur atomsC07D 241/08 with oxygen atoms directly ...C07D 243/08 not condensed with other ringsC07D 401/06 linked by a carbon chain co...C07D 401/12 linked by a chain containin...C07D 401/14 containing three or more he...C07D 409/12 linked by a chain containin...C07D 409/14 containing three or more he...C07D 413/12 linked by a chain containin...C07D 413/14 containing three or more he...