Apparatus for access to interstitial fluid, blood, or blood plasma components
First Claim
Patent Images
1. An transcutaneous implant comprising:
- an access component to provide a stable dermal interface;
a central housing disposed within the access component, the central housing having a first end for external access and a second end;
a first septum disposed within the central housing; and
a filtration membrane disposed at the second end of the central housing to promote neovascularization and transfer of analyte in bodily fluid into a reservoir formed by the filtration membrane, the first septum and the central housing.
0 Assignments
0 Petitions
Accused Products
Abstract
A transcutaneous implant having a stable biological seal at the skin interface, obviating the need for puncturing the skin to obtain fluid samples is described. The implant includes an advanced filtration membrane to promote neovascularization which eliminates mass transfer problems by promoting the development of capillary networks with transcapillary mass transfer rates high enough to insure rapid exchange of analyte between blood and the device. Additionally the membrane provides a bioprotective layer which prevents transport of proteins and cellular components into the device.
93 Citations
58 Claims
-
1. An transcutaneous implant comprising:
-
an access component to provide a stable dermal interface;
a central housing disposed within the access component, the central housing having a first end for external access and a second end;
a first septum disposed within the central housing; and
a filtration membrane disposed at the second end of the central housing to promote neovascularization and transfer of analyte in bodily fluid into a reservoir formed by the filtration membrane, the first septum and the central housing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
-
-
43. A sensing system having a transcutaneous implant device comprising:
-
an electroenzymatic sensor;
a transcutaneous implant device, including;
an access component to provide a stable dermal interface;
a central housing disposed within the access component, the central housing having a first end for external access and a second end;
a first septum disposed within the central housing; and
a filtration membrane disposed at the second end of the central housing to promote neovascularization and transfer of analyte in bodily fluid into a reservoir formed by the filtration membrane, the first septum and the central housing. - View Dependent Claims (44, 45, 46, 47, 48, 50, 51, 52)
-
-
49. An apparatus for safely withdrawing bodily fluid from a transcutaneous implant, the apparatus comprising:
-
a projecting portion adapted to extend through a septum of the transcutaneous implant and into a collection reservoir of the implant; and
a flange adapted to engage a stop wall of the transcutaneous implant such that the projecting portion of the apparatus is prevented from contacting a filtration membrane of the transcutaneous implant.
-
-
53. An apparatus for safely withdrawing bodily fluid from a transcutaneous implant, the apparatus comprising:
-
a chamber;
an aspirator operable to create suction pressure within the chamber; and
a projecting portion adapted to extend through a septum of the transcutaneous implant and into a collection reservoir of the transcutaneous implant, the projecting portion including a tip having an aperture, and a passage extending between the chamber and the aperture, the tip of the projecting portion being configured to engage a safety stop disposed within the collection reservoir of the transcutaneous implant such that tip of the aperture is prevented from contacting a filtration membrane of the transcutaneous implant and such that the aperture is unblocked and able to receive the bodily fluid when the aspirator is operated to create suction pressure within the chamber. - View Dependent Claims (54)
-
-
55. A septum for forming a liquid-tight seal within a lumen of a transcutaneous implant, the septum comprising:
-
an outer surface for engaging the lumen of the transcutaneous implant; and
a first self-sealing aperture disposed within the outer surface. - View Dependent Claims (56, 57, 58)
-
Specification