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Sample separation apparatus and method for multiple channel high throughput purification

  • US 20020185442A1
  • Filed: 07/30/2002
  • Published: 12/12/2002
  • Est. Priority Date: 10/30/1998
  • Status: Abandoned Application
First Claim
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1. A high throughput liquid chromatography column assembly configured to receive a selected sample for chromatographic separation, comprising:

  • a loading column having a loading chamber;

    a cartridge removably retained in the loading chamber, the cartridge containing a first packing material with a vertical absorptive profile and a selected volume to spatially distribute the sample within the cartridge to load the sample prior to chromatographic separation of the sample, the cartridge having a first diameter and a first length, the first length of the cartridge being insufficient to achieve the selected chromatographic separation of the sample as the sample passes through the first packing material; and

    a separation column having a separation chamber and a second packing material therein in fluid connection with the loading chamber and being positioned to receive the sample from the loading column, the separation chamber having a second length greater that the first length, sufficient to achieve the selected chromatographic separation of the sample as the sample passes therethrough.

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