Calcuim phosphate delivery vehicles for osteoinductive proteins
First Claim
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1. A composition for delivery of osteogenic proteins, which comprises an osteogenic protein as a first biologically active agent, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent.
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Abstract
A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
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Citations
35 Claims
- 1. A composition for delivery of osteogenic proteins, which comprises an osteogenic protein as a first biologically active agent, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent.
- 11. A composition for delivery of osteogenic proteins, which comprises a bone morphogenic protein as a first biologically active agent, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent, wherein the effervescent agent is a gas selected from the group consisting of carbon dioxide, air, nitrogen, helium oxygen, and argon.
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12. A composition for delivery of osteogenic proteins, which comprises a bone morphogenic protein as a first biologically active agent, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent, wherein the effervescent is sodium bicarbonate.
- 21. A method of treating a mammal having a bone defect comprising administering to the site of bone defect an effective amount of an osteogenic composition, wherein the osteogenic composition comprises mixing a bone morphogenetic protein, a calcium phosphate material, and an effervescent agent.
- 31. A method of treating a mammal having a bone defect comprising administering to the site of bone defect an effective amount of an osteogenic composition, wherein the osteogenic composition comprises mixing a bone morphogenetic protein, a calcium phosphate material, and sodium bicarbonate.
Specification