Diagnostic method for assessing a condition of a performance animal
First Claim
1. A method for assessing a condition of a performance animal including the steps of:
- (a) determining in a sample from a performance animal a relative abundance of a target nucleic acid normalised to a reference nucleic acid and providing the relative abundance of the target nucleic acid as a digital signal;
(b) accessing a remotely located database comprising digital information in relation to relative abundance of the target nucleic acid which corresponds to a particular condition of the performance animal;
(c) correlating the digital signal of step (a) with the digital information of step (b) thereby identifying a particular condition of the performance animal; and
(d) reporting the particular condition of the performance animal.
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Abstract
The condition and ability of an animal to perform to its best ability may be determined by correlating gene expression with clinical and other data. The methods include collecting biological samples and clinical history, generating digital results on gene expression levels in the samples, remotely accessing and comparing the results with information via a communications network. The invention provides methods for assessing a performance animal'"'"'s condition by determining relative abundance of a target nucleic acid, accessing a remote database, correlating digital signals with information in the database, and reporting the condition of the animal. A diagnostic system comprising a microarray, a microarray reader, a database for storing information from the reader, and a server receiving digital signals from the reader is also disclosed. The reader determines the abundance of target nucleic acid, normalised to a reference nucleic acid, and generates a digital signal that may be displayed as a report.
69 Citations
24 Claims
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1. A method for assessing a condition of a performance animal including the steps of:
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(a) determining in a sample from a performance animal a relative abundance of a target nucleic acid normalised to a reference nucleic acid and providing the relative abundance of the target nucleic acid as a digital signal;
(b) accessing a remotely located database comprising digital information in relation to relative abundance of the target nucleic acid which corresponds to a particular condition of the performance animal;
(c) correlating the digital signal of step (a) with the digital information of step (b) thereby identifying a particular condition of the performance animal; and
(d) reporting the particular condition of the performance animal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A diagnostic system comprising:
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(A) a microarray comprising respective nucleic acids complimentary to a target nucleic acid and reference nucleic acid;
(B) a microarray reader that detects hybridised complexes formed respectively by the target nucleic acid and the reference nucleic acid with their complimentary nucleic acids and generates a digital signal;
(C) a database storing information in relation to relative abundance of the target nucleic acid corresponding to a particular condition of a performance animal;
(D) a diagnostic server that receives the digital signal and correlates the digital signal with information in the database to identify said particular condition and reports said particular condition; and
(E) a means for communicating between the microarray reader and the diagnostic server. - View Dependent Claims (22, 23, 24)
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Specification