Sensor surfaces for detecting analytes
First Claim
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1. A sensor surface, said sensor surface comprising:
- a substrate coated with a free electron metal; and
a matrix layer disposed on said free electron metal, said matrix layer comprising an organic compound, wherein said organic compound has a boronic acid complexing moiety.
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Abstract
The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises an organic compound having a boronic acid complexing moiety. The matrix is preferably a self-assembled monolayer (SAM), a mixed self-assembled monolayer (mSAM), or combinations thereof.
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Citations
42 Claims
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1. A sensor surface, said sensor surface comprising:
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a substrate coated with a free electron metal; and
a matrix layer disposed on said free electron metal, said matrix layer comprising an organic compound, wherein said organic compound has a boronic acid complexing moiety. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 39, 40, 41, 42)
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36. A sensor surface, said sensor surface comprising:
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a substrate coated with a free electron metal;
a matrix layer disposed on said free electron metal, said matrix layer comprising an organic compound, wherein said organic compound has the formula wherein;
Y1 is a member selected from the group consisting of a boronic acid complexing moiety, a binding partner, a cell, a receptor, a liposome, a vesicle, an artificial membrane, a protein, a polypeptide, a protein fragment, a polypeptide fragment, a peptide hormone, a nucleic acid, a toxin, a hapten, a hormone, a sugar, biotin, a vitamin, and combinations thereof.
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37. A sensor surface, said sensor surface comprising:
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a substrate coated with a free electron metal;
a matrix layer disposed on said free electron metal, said matrix layer comprising an organic compound, wherein said organic compound has the formula X—
R′
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BASX is an anchor group that forms a complex with said free-electron metal;
R1 is an optionally substituted alkylene group having an amido group; and
BAS is a bioactive species.
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38. A process for immobilizing a ligand on a sensor surface, said process comprising:
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admixing a boronic acid reagent having a reactive group with a ligand to form a boronic acid-ligand conjugate; and
incubating said boronic acid-ligand conjugate with said sensor surface, thereby immobilizing said ligand.
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Specification