Compositions and methods for decreasing the risk of or preventing neural tube disorders in mammals

• US 20020193379A1
• Filed: 05/15/2002
• Published: 12/19/2002
• Est. Priority Date: 06/05/2001
• Status: Abandoned Application

• Current Assignee: Insmed Incorporated
• Original Assignee: Insmed Incorporated
• Inventors: Copp, Andrew J., Allan, Geoffrey
• Application Number:
  US10/144,767
• Publication Number:
  US 20020193379A1
• Time in Patent Office: Days
• US Class Current: 514/251
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2

Abstract

This invention relates to compositions and methods for decreasing the risk of or preventing neural tube disorders in mammals. These compositions contain an effective amount of D-chiro-inositol or a combination of effective amounts of D-chiro-inositol and folic acid.

Claims

1. A method for decreasing the risk of or preventing neural tube disorders in a mammal comprising administering to a mammal an effective amount of D-chiro-inositol or a derivative or metabolite thereof.

2. The method of claim 1, wherein D-chiro-inositol is administered.

3. The method of claim 1, wherein said effective amount of D-chiro-inositol is in the range of about 3 to about 300 mg/kg/day.

4. The method of claim 3, wherein said effective amount of D-chiro-inositol is in the range of about 5 to about 180 mg/kg/day.

5. The method of claim 1, wherein an effective amount of folic acid is administered with said D-chiro-inositol.

6. The method of claim 5 wherein the effective amount of folic acid is about 0.5 mg/day to about 5.0 mg/day.

7. The method of claim 6, wherein the effective amount of folic acid is about 1.0 mg/day to about 4.0 mg/day.

8. A method for decreasing the risk of or preventing neural tube disorders in a mammal comprising administering to a mammal a composition comprising an effective amount of D-chiro-inositol, or a derivative or metabolite thereof, and an effective amount of folic acid.

9. A composition comprising:

(a) about 25 to about 1000 milligrams of a compound selected from the group consisting of D-chiro-inositol;

D-chiro-inositol phosphate;

D-chiro-inositol ester;

D-chiro-inositol ether;

D-chiro-inositol acetals;

D-chiro-inositol ketals;

fagopyritol; and

D-chiro-inositol amino dissacharides; and

(b) about 1 to about 5 milligrams of folic acid.

10. The composition of claim 9 wherein the compound is D-chiro-inositol.