Guided Radiation Therapy System
First Claim
1. A target locating and tracking system usable with a radiation therapy delivery source that delivers radiation to a target in a body, the radiation being delivered to a predetermined volume configured around a machine isocenter spaced apart from the radiation delivery source, comprising:
- a marker fixable at a position relative to the target in the body, the marker being excitable by an external excitation source to produce an identifiable marker signal from the marker while in the body;
sensors spaced apart from each other in a known geometry relative to each other and positioned to identify the marker signal from the marker, the sensors being configured to measure the marker signal and to provide marker measurement signals;
a reference device positionable at a selected position relative to the radiation therapy delivery source and the machine isocenter, the reference device configured to produce a reference signal measurable by a plurality of the sensors; and
a data processing unit coupled to the sensors to receive the marker measurement signals, the data processing unit being configured to use the marker measurement signals to determine the location of the target volume with a target isocenter and the location of the reference device relative to the plurality of sensors, and the data processing unit being configured to identify the location of the target isocenter relative to the machine isocenter.
3 Assignments
0 Petitions
Accused Products
Abstract
A system and method for accurately locating and tracking the position of a target, such as a tumor or the like, within a body. In one embodiment, the system is a target locating and monitoring system usable with a radiation delivery source that delivers selected doses of radiation to a target in a body. The system includes one or more excitable markers positionable in or near the target, an external excitation source that remotely excites the markers to produce an identifiable signal, and a plurality of sensors spaced apart in a known geometry relative to each other. A computer is coupled to the sensors and configured to use the marker measurements to identify a target isocenter within the target. The computer compares the position of the target isocenter with the location of the machine isocenter. The computer also controls movement of the patient and a patient support device so the target isocenter is co-incident with the machine isocenter before and during radiation therapy.
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Citations
81 Claims
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1. A target locating and tracking system usable with a radiation therapy delivery source that delivers radiation to a target in a body, the radiation being delivered to a predetermined volume configured around a machine isocenter spaced apart from the radiation delivery source, comprising:
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a marker fixable at a position relative to the target in the body, the marker being excitable by an external excitation source to produce an identifiable marker signal from the marker while in the body; sensors spaced apart from each other in a known geometry relative to each other and positioned to identify the marker signal from the marker, the sensors being configured to measure the marker signal and to provide marker measurement signals; a reference device positionable at a selected position relative to the radiation therapy delivery source and the machine isocenter, the reference device configured to produce a reference signal measurable by a plurality of the sensors; and
a data processing unit coupled to the sensors to receive the marker measurement signals, the data processing unit being configured to use the marker measurement signals to determine the location of the target volume with a target isocenter and the location of the reference device relative to the plurality of sensors, and the data processing unit being configured to identify the location of the target isocenter relative to the machine isocenter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A target locating and monitoring system usable with a radiation therapy delivery source that delivers radiation to a target in a body, the radiation being delivered to a treatment volume determined by a machine isocenter spaced apart from the radiation therapy delivery source, comprising:
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a plurality of markers fixable on or in the body at a known geometry relative to each other and relative to the target, the markers each being excitable by an external excitation source to produce an identifiable marker signal from the marker while in the body; sensors spaced apart from each other and positioned to measure the marker signals from the markerseach sensor being configured to provide marker measurement signals for one or more of the markers; a reference device positionable at a selected position relative to the radiation delivery source and the machine isocenter; and
a data processing unit coupled to the sensors to receive the marker measurement signals from the sensors, the data processing unit being configured to use the marker measurement signals to determine the location of the target volume having a target isocenter relative to the plurality of sensors, and the data processing unit being configured to identify the location of the target isocenter relative to the machine isocenter. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A radiation therapy delivery system usable to irradiate a selected target within a body, comprising:
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a radiation delivery assembly that delivers radiation from a radiation therapy delivery source to a machine isocenter spaced apart from the radiation delivery source;
a marker fixable in or on the body at a position relative to the target, the marker being excitable by an external source to produce a measurable marker signal while in the body; a plurality of sensors spaced apart from each other and positioned in a known geometry relative to each other, the sensors being configured to measure the marker signals and generate marker measurement signals; a reference device coupled to the radiation therapy delivery source and positioned remote from the machine isocenter; and
a data processing unit coupled to the sensors to receive the marker measurement signals, the data processing unit being configured to use the marker measurement signals to determine the location of the target volume having a target isocenter and the location of the reference device relative to the plurality of sensors, and the data processing unit being configured to identify the location of the target isocenter relative to the machine isocenter. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 54)
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51. A radiation treatment system usable to deliver ionizing radiation to a selected target within a body, comprising:
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a movable gantry configurable to deliver the ionizing radiation at a treatment isocenter remote from the gantry; a marker fixable at a position relative to the target within the body, the marker being excitable by an external source to produce a measurable marker signal while in the body; sensors spaced apart in a known geometry relative to each other and positioned to measure the marker signal, each sensor being configured to measure the marker signal and provide a marker measurement signal; a linear accelerator reference device mounted on the gantry at a known position relative to the machine isocenter; and
a computer controller coupled to the sensors to receive the marker measurement signals and configured to use the marker measurement signals to determine the location of the target volume and a target isocenter in the target volume relative to the sensors, and the computer controller being coupled to the reference device and configured to identify the location of the target isocenter relative to the machine isocenter. - View Dependent Claims (52, 53, 55)
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56. A radiation target alignment system usable with a radiation delivery source that delivers selected doses of radiation to a selected target in a body, comprising:
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an imaging system configured to obtain image data of the target and at least one marker positioned within the body, and to define a simulated target model having a spatial relationship and orientation within the body using the image data; a marker implantable in or on the body at a selected position relative to the target, the marker being excitable by an external source to produce a measurable signal while in the body; a plurality of sensors spaced apart in a known geometry relative to each other and positioned to identify the signal from the marker in the body, each sensor being configured to measure the marker signal and provide a marker measurement signal; a data processing unit coupled to the sensors to receive the marker measurement signal for the marker, the data processing unit being configured to use the marker measurement signal and the image data to determine an actual target model of the target'"'"'s actual location within the body relative to the plurality of sensors, and to identify a target isocenter within the target, the data processing unit being configured to compare and align the actual target model and the simulated target model in preparation for radiation treatment of the target. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63)
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64. An adjustable patient support assembly for use with a radiation delivery system that delivers radiation to a selected target in a body, the radiation being delivered to a machine isocenter spaced apart from the radiation delivery source, comprising:
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a base;
a support structure attached to the base; sensors spaced apart from each other in a known geometry relative to each other and coupled to the base, the sensors being positioned to measure a signal from an excitable marker implantable in the body at a selected position relative to the target, each sensor being configured to provide signal measurement data; a data processing unit coupled to the sensors to receive the signal measurement data for the marker, the data processing unit being configured to use the signal measurement data for the marker to determine the location of the target and a target isocenter in the target relative to the sensors, the data processing unit being configured to identify the location of the target isocenter relative to the machine isocenter; and
a movement control device connected to the support structure to selectively move the support structure relative to the base and the sensors, the movement control device coupled to the data processing unit and being movable in response to the information from the data processing unit to position the target isocenter co-incident with the machine isocenter.
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65. A method of identifying and tracking a selected target in a body for application of radiation to the target from a radiation delivery source, comprising:
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determining a general location of the target in the body; implanting a marker in the body at a selected position relative to the target, the marker being excitable by an external excitation source to produce an identifiable marker signal while in the body; exciting the implanted marker with the external excitation source to produce the identifiable marker signal; measuring the marker signal from the implanted marker with sensors exterior of the body, the sensors being positioned at a known geometry relative to each other; determining a target isocenter in the target within the body based upon the measurements from the sensors of the marker signal; determining a position of a reference device relative to the plurality of sensors, the reference device being located at a known geometry relative to the radiation delivery device; determining the location of a machine isocenter relative to the plurality of sensors based upon the position of the reference device; positioning the body relative to the radiation delivery device with the target isocenter being coincident with the machine isocenter; and applying radiation from the radiation delivery device to the machine isocenter and the target at the target isocenter. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
implanting a plurality of markers in the body at a selected positions and orientations relative to the target, each marker being excitable by the external excitation source to produce an identifiable marker signal unique to the respective marker; exciting the implanted markers with the external excitation source to produce the identifiable unique marker signals; measuring the marker signals from each of the implanted markers with the sensors exterior of the body; determining a location of the target isocenter in the target within the body based upon the measurements from the sensors of the marker signals.
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67. The method of claim 65, further comprising determining the location and orientation of the target in the body relative to the sensors.
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68. The method of claim 65 wherein the marker generates the marker signal having a signal strength and measuring the marker signals includes measuring the marker strength with each sensor.
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69. The method of claim 65, further comprising providing a monitoring system coupled to a computer controller and providing feedback from the computer controller to the monitoring system about the position of the machine isocenter and the target isocenter relative to each other.
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70. The method of claim 69 wherein the monitoring system includes a visual display portion, and providing feedback includes providing a visual representation on the visual display portion of the positions of the target and machine isocenters relative to each other.
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71. The method of claim 65, further comprising implanting at least three markers in the body at selected positions relative to the target, each of the at least three markers being axially misaligned with each other.
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72. The method of claim 65 further comprising positioning the body at a selected location generally adjacent to the radiation delivery source, and wherein measuring the marker signal, determining a location of the target isocenter, determining the location of a machine isocenter, and positioning the body relative to the radiation delivery device so the target isocenter being coincident with the machine isocenter are performed in real time prior while the body is positioned at the selected location generally adjacent to the radiation delivery device.
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73. The method of claim 65 wherein the target is a tumor, and implanting the marker includes implanting the marker in or immediately adjacent to the tumor, and determining the location of the target isocenter includes determining a location of the target isocenter in the tumor.
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74. The method of claim 65 wherein the sensors are mounted to a movable support table that supports the body generally adjacent to the radiation delivery device, and positioning the body includes moving a portion of the support table relative to the radiation delivery device and to the sensors to align the target isocenter with the machine isocenter.
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75. The method of claim 65, further comprising monitoring the position of the target isocenter relative to the machine isocenter in real time during irradiation of the target, and interrupting the irradiation of the target if the target isocenter moves out of alignment with the machine isocenter.
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76. A method of delivering radiation therapy on a selected target within a body, comprising:
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implanting a marker in the body at a selected position relative to the target, exciting the implanted marker with an excitation source external of the body to produce an identifiable marker signal; measuring the marker signal from the implanted marker with sensors positioned exterior of the body and at a known geometry relative to each other; determining a target isocenter in the target within the body based upon the measurements from the sensors of the marker signal; determining the location of a machine isocenter of a radiation delivery assembly relative to the plurality of sensors based upon the position of the reference device and relative to the target isocenter; positioning the body relative to the radiation delivery device so the target isocenter is co-incident with the machine isocenter; applying radiation from the radiation delivery device to target at the target isocenter and the machine isocenter; and monitoring in real-time the actual position of the target isocenter relative to the machine isocenter during application of the radiation to the target.
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77. A radiation treatment planning method for establishing a therapeutic procedure for delivering ionizing radiation to a selected target, comprising:
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obtaining imaging data of a selected target within a body; implanting an excitable marker in the body at a selected location relative to the target; exciting the implanted marker with the external excitation source to produce the identifiable marker signal from the marker while in the body; measuring the marker signal from the implanted marker with a plurality of sensors exterior of the body, the sensors being positioned at a known geometry relative to each other; determining a shape, and spatial orientation of the target within the body from the imaging data; determining a target isocenter in the target within the body based upon the measurements from the sensors of the marker signal; and
developing a radiation dosage and delivery protocol for irradiating the target at the target isocenter based upon the shape and spatial orientation of the target. - View Dependent Claims (78, 79)
positioning the body with the target and implanted marker therein at a selected position relative to a radiation delivery assembly, the radiation delivery assembly being configured to selectively deliver focused radiation to a target isocenter spaced apart from the radiation delivery assembly; determining the location of a machine isocenter relative to the plurality of sensors; positioning the body relative to the radiation delivery device with the target isocenter being substantially co-incident with the machine isocenter; and delivering the radiation from the radiation delivery assembly to the machine isocenter and to the target at the target isocenter.
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79. The method of claim 77, further comprising defining a three-dimensional simulated target model with a selected position and orientation relative to the body based upon the imaging data;
- and defining an three-dimensional actual target based upon the measurements of the marker signals, providing a feedback device that provides feedback information about the location and orientation of the simulated target model and the actual target model, and moving the body to align orientation of the target and actual models prior to the delivery of the radiation to the target.
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80. A method of positioning a body relative to a radiation delivery device for delivery of radiation to a target within the body, comprising:
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positioning the body on a movable support assembly; exciting an excitable marker with an excitation source exterior of the body, the marker being implanted within the body at a selected position relative to the target, the excited marker providing an identifiable marker signal; measuring the marker signal from the implanted marker with a plurality of sensors exterior of the body, the plurality of sensors being positioned at a known geometry relative to each other and relative to the support assembly; determining a target isocenter in the target within the body based upon the measurements from the sensors of the marker signal; determining the location of a machine isocenter relative to the plurality of sensors based upon the position of the radiation delivery assembly; comparing the location of the target isocenter with the location of the machine isocenter; and moving a portion of the support portion and the body together relative to the machine isocenter to position the target isocenter co-incident with the machine isocenter. - View Dependent Claims (81)
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Specification