Droplet polymerization method for synthesis of molecularly imprinted polymers
First Claim
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1. A droplet polymerization process to form a molecularly imprinted polymer, comprising the steps of:
- b) Releasing a monomer-template reaction mixture comprising (iii) at least one monomer; and
(iv) at least one template molecule as droplets into a liquid suspending medium, wherein at least one of the monomer-template reaction mixture and the liquid suspending medium further comprises a polymerization initiator system, whereby polymerization of each droplet is at least substantially completed in the suspending medium; and
b) Recovering the molecularly imprinted polymer from the suspending medium.
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Abstract
A droplet polymerization process is provided to create efficacious molecularly imprinted polymers (MIPs). Such imprinted polymers have increased surface area for adsorptive or catalytic reactions. This method provides for monomer-template interactions in the absence of a suspending medium, thereby permitting formation of MIPs with increased template selectivity and substantial processing advantages. The process is particularly useful for separating isoflavones from soy whey.
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36 Claims
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1. A droplet polymerization process to form a molecularly imprinted polymer, comprising the steps of:
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b) Releasing a monomer-template reaction mixture comprising (iii) at least one monomer; and
(iv) at least one template molecule as droplets into a liquid suspending medium, wherein at least one of the monomer-template reaction mixture and the liquid suspending medium further comprises a polymerization initiator system, whereby polymerization of each droplet is at least substantially completed in the suspending medium; and
b) Recovering the molecularly imprinted polymer from the suspending medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A droplet polymerization process to form a molecularly imprinted polymer, comprising the steps of:
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a. releasing a monomer-template reaction mixture, comprising;
i. at least one monomer selected from the group consisting of functional monomers and crosslinking monomers;
ii. at least one template selected from the group consisting of estradiol benzoate, phenol, genistein, daidzein, glycitein, genistin, daidzin, glycitin, malonyl genistin, malonyl daidzin, malonyl glycitin, acetyl genistin, acetyl daidzin, and acetyl glycitin;
as droplets from an orifice into a liquid suspending medium, wherein at least one of the monomer-template reaction mixture and the liquid suspending medium further comprises a polymerization initiator system, whereby polymerization of the droplets is at least substantially completed in the suspending medium; and
b. recovering the molecularly imprinted polymer from the suspending medium; and
c. extracting the template from the molecularly imprinted polymer before or after step (b). - View Dependent Claims (33, 36)
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34. A droplet polymerization process to form a molecularly imprinted polymer for use in adsorbing a target analyte from a sample, comprising the steps of:
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a. releasing a monomer-template reaction mixture, comprising;
i. at least one monomer selected from the group consisting of functional monomers and crosslinking monomers;
ii. at least one template selected from the group consisting of estradiol benzoate, phenol, genistein, daidzein, glycitein, genistin, daidzin, glycitin, malonyl genistin, malonyl daidzin, malonyl glycitin, acetyl genistin, acetyl daidzin, and acetyl glycitin;
as droplets from an orifice into a liquid suspending medium, wherein at least one of the monomer-template reaction mixture and the liquid suspending medium further comprises a polymerization initiator system, whereby polymerization of the droplets is at least substantially completed in the suspending medium;
b. recovering the molecularly imprinted polymer from the suspending medium;
c. extracting the template from the molecularly imprinted polymer before or after step (b);
d. contacting the molecularly imprinted polymer with a sample comprising a target analyte; and
e. separating the target analyte from the molecularly imprinted polymer. - View Dependent Claims (35)
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Specification