Intradermal delivery of vaccines and gene therapeutic agents via microcannula
First Claim
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1. A method for delivering a vaccine to a mammal, said method comprising intradermally administering the vaccine through at least one hollow needle having an outlet with an exposed height between 0 and 1 mm , said outlet being inserted into the skin to a depth of between 0.5 mm and 2 mm.
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Abstract
Methods and devices for administration of vaccines and gene therapeutic agents into the intradermal layer of skin.
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Citations
60 Claims
- 1. A method for delivering a vaccine to a mammal, said method comprising intradermally administering the vaccine through at least one hollow needle having an outlet with an exposed height between 0 and 1 mm , said outlet being inserted into the skin to a depth of between 0.5 mm and 2 mm.
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40. A method for delivering a vaccine to a mammal, said method comprising:
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a) contacting the skin of the mammal with a device having a dermal-access means for accurately targeting a dermal space of the skin at a depth between 0.025 mm and 2.5 mm with the vaccine; and
b) delivering the vaccine to the dermal space. - View Dependent Claims (41, 42)
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- 43. A method for delivering a gene therapeutic agent to a mammal, said method comprising administering the therapeutic agent through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm, said outlet being inserted into the skin to a depth of between 0.5 mm and 2 mm.
- 54. A kit comprising a delivery device having at least one hollow microneedle designed to intradermally deliver a substance to a depth between 0.025 and 2.5 mm, said delivery device being adapted to receive a reservoir that contains a gene therapeutic agent or vaccine such that the microneedle is in communication therewith.
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60. A kit comprising a dermal access means designed to intradermally deliver a substance to a depth between 0.025 and 2.5 mm, said dermal access means being adapted to receive a reservoir that contains a gene therapeutic agent or vaccine such that the dermal access means is in communication therewith.
Specification