Method and device for subretinal drug delivery
First Claim
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1. A device for treating an eye, comprising:
- a piercing member having a length and an outer diameter, the piercing member having proximal end and a distal end and a lumen extending therebetween, the distal end being of sufficient sharpness to penetrate an insertion site of the device; and
a cannula slidably insertable within the piercing member, the cannula having a length longer than the length of the piercing member and having a distal end of sufficient sharpness to penetrate a treatment site, wherein the outer diameter of the piercing member is small enough to allow for self-sealing of the insertion site upon removal of the piercing member from the insertion site.
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Abstract
Devices and devices for the treatment of the eye are disclosed. Preferred devices of the invention include a piercing member that is inserted into the eye to create a pathway for a cannula. The cannula is slidably mounted to the piercing member and is adapted to reach a treatment site within the eye at which material is injected into and/or withdrawn from the eye. The outer diameter of the piercing member is small enough to allow for self-sealing of the insertion site of the device upon the device'"'"'s withdrawal therefrom. Also disclosed are methods for the utilizing the devices to treat the eye.
85 Citations
35 Claims
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1. A device for treating an eye, comprising:
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a piercing member having a length and an outer diameter, the piercing member having proximal end and a distal end and a lumen extending therebetween, the distal end being of sufficient sharpness to penetrate an insertion site of the device; and
a cannula slidably insertable within the piercing member, the cannula having a length longer than the length of the piercing member and having a distal end of sufficient sharpness to penetrate a treatment site, wherein the outer diameter of the piercing member is small enough to allow for self-sealing of the insertion site upon removal of the piercing member from the insertion site. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 21, 22, 24, 25, 28, 29)
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2. A device for treating an eye, comprising a piercing member and a cannula insertable within the piercing member, the cannula having a length longer than the length of the piercing member.
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10. A device for treating an eye, comprising:
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a piercing member having a length and an outer diameter, the piercing member having proximal end and a distal end and a lumen extending therebetween, the distal end being of sufficient sharpness to penetrate an insertion site of the device;
a rigid member disposed within the piercing member lumen and having a proximal end and a distal end and a lumen extending therebetween, the rigid member having a length greater than the length of the piercing member;
a cannula disposed within and connected to rigid member lumen, the cannula having a length longer than the length of each of the piercing member and the rigid member, and having a distal end of sufficient sharpness to penetrate a treatment site. - View Dependent Claims (11, 12, 13, 14, 15, 16, 18, 19)
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17. A device for treating an eye, comprising:
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a piercing member having a length and an outer diameter, the piercing member having proximal end and a distal end and a lumen extending therebetween, the distal end being of sufficient sharpness to penetrate an insertion site of the device;
a handle having a length, a proximal end and a distal end and a substantially hollow portion, the distal end of the handle being mounted to the piercing member, and the handle lumen being sized to accommodate the outer diameter of the cannula;
a quantity of tubing having a proximal end and a distal end and a lumen extending therebetween, the distal end of the tubing being disposed within the substantially hollow portion of the handle; and
a cannula connected to, and disposed at least partially within the tubing lumen, the cannula having an outer diameter such that the cannula is substantially flush with the tubing lumen, and having a distal end of sufficient sharpness to penetrate a treatment site. - View Dependent Claims (20)
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23. A method for treating an eye comprising:
inserting into an eye a device comprising a piercing member and a cannula insertable within the piercing member, the cannula having a length longer than the length of the piercing member. - View Dependent Claims (26)
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27. A method of treating an eye, comprising:
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inserting a piercing member having an outer diameter into an insertion site, the piercing member having a proximal end and a distal end and a lumen defined therebetween;
advancing a cannula through the piercing member lumen, the cannula having a proximal end and a distal end;
guiding the cannula to a treatment site;
treating the treatment site;
withdrawing the cannula from the piercing member; and
withdrawing the piercing member from the insertion site, wherein the outer diameter of the piercing member is small enough to allow the insertion site to self-seal following withdrawal of the piercing member. - View Dependent Claims (30, 31, 32, 33, 34, 35)
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Specification