Electroporation microneedle and methods for its use
First Claim
Patent Images
1. A method for delivering substances to solid tissue, said method comprising:
- penetrating a shaft into the solid tissue;
delivering the substance through the shaft to a target site in the solid tissue; and
applying an electric field to the target site through an electrode structure on the shaft.
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Abstract
Electroporation of cells in target tissues is performed using microneedles having integral electrode structures. In a first embodiment, a pair of electrode structures are disposed on opposite sides of a substance delivery opening on a needle or other tissue-penetrating shaft. In a second embodiment, a first electrode structure is disposed on the needle and a second electrode structure is disposed on an attached base. The electrode structures are spaced closely together and relatively low voltages are applied to achieve electroporation-enhanced substance delivery.
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Citations
28 Claims
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1. A method for delivering substances to solid tissue, said method comprising:
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penetrating a shaft into the solid tissue;
delivering the substance through the shaft to a target site in the solid tissue; and
applying an electric field to the target site through an electrode structure on the shaft. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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13. An electroporation apparatus comprising:
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a base;
a shaft having a distal end, a proximal end, and a lumen extending from a proximal location to an opening at a distal location on the shaft;
a first electrode structure disposed on the shaft near the distal location; and
a second electrode structure disposed on the shaft or the base and spaced-apart from the first electrode structure.
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Specification