Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
First Claim
1. A method of producing a neural cell, said method comprising contacting an isolated marrow stromal cell with a cyclic AMP-stimulating compound, thereby increasing the intracellular level of cyclic AMP in said marrow stromal cell and producing a neural cell.
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Abstract
The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods of producing a neural cell by causing a marrow stromal cell to differentiate into a neural cell by increasing intracellular levels of cyclic AMP. Methods for treating a human patient in need of neural cells are also disclosed, as well as methods for treating a human patient having a disease, condition, or disorder of the central nervous system.
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20 Claims
- 1. A method of producing a neural cell, said method comprising contacting an isolated marrow stromal cell with a cyclic AMP-stimulating compound, thereby increasing the intracellular level of cyclic AMP in said marrow stromal cell and producing a neural cell.
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12. A method of inducing differentiation of an isolated marrow stromal cell into a neural cell, said method comprising contacting said marrow stromal cell with a cyclic AMP stimulating compound.
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