Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
First Claim
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1. A composite scaffold, comprising:
- a ceramic phase having a first plurality of pores;
a polymer phase having a second plurality of pores, said polymer phase attached to said ceramic phase at an interphase region, said polymer phase infused at least partially into said first plurality of pores in said interphase region.
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Abstract
A composite scaffold with a porous ceramic phase and a porous polymer phase. The polymer is foamed while in solution that is infused in the pores of the ceramic to create a interphase junction of interlocked porous materials. The preferred method for foaming is by lyophilization. The scaffold may be infused or coated with a variety of bioactive materials to induce ingrowth or to release a medicament. The multi-layered porous scaffold can mimic the morphology of an injured tissue junction with a gradient morphology and cell composition, such as articular cartilage.
194 Citations
28 Claims
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1. A composite scaffold, comprising:
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a ceramic phase having a first plurality of pores;
a polymer phase having a second plurality of pores, said polymer phase attached to said ceramic phase at an interphase region, said polymer phase infused at least partially into said first plurality of pores in said interphase region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 26, 27, 28)
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23. A method for making a composite scaffold having a porous ceramic phase and a porous polymer phase, comprising the steps of:
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(A) providing a porous ceramic body;
(B) providing a polymer solution;
(C) placing said porous ceramic body in contact with said polymer solution;
(D) permitting said polymer solution to at least partially infuse into pores in said ceramic body;
(E) foaming said polymer solution to produce a polymer foam thereby forming the porous polymer phase, the polymer phase interlocking with the ceramic body where the polymer solution was permitted to infuse into the ceramic body.
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25. A method for repairing a defect area at the gradient junction of cartilaginous tissue and bony tissue, comprising the steps of:
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(A) providing a composite scaffold with a porous ceramic phase, a porous polymer phase, the polymer phase attached to the ceramic phase at an interphase region where the polymer phase is at least partially infused into the ceramic phase mechanically interlocking the ceramic and polymer phases, with the porosity of the ceramic and polymer phases communicating;
(B) boring a receptacle space in the gradient junction at the site of the injury to receive the scaffold provided in step (A);
(C) placing and securing the scaffold in the receptacle space with the ceramic phase adjacent to the bony tissue and the polymer phase adjacent to the cartilaginous tissue.
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Specification