Cationic ion pairing compositions having volatile combustion products with O or S or halogen atoms or their combinations as heteroatoms for use with gas-phase or vapor-phase element-specific detectors

• US 20030004371A1
• Filed: 05/15/2002
• Published: 01/02/2003
• Est. Priority Date: 05/23/2001
• Status: Abandoned Application

• Current Assignee: Texas A&M University System
• Original Assignee: Texas A&M University System
• Inventors: Vigh, Gyula
• Application Number:
  US10/146,476
• Publication Number:
  US 20030004371A1
• Time in Patent Office: Days
• US Class Current: 562/400
• CPC Class Codes: B01D 15/345 Perfusive chromatography
• CPC Class Codes: B01D 15/366 Ion-pair, e.g. ion-pair reversed phase
• CPC Class Codes: G01N 30/02 Column chromatography
• CPC Class Codes: G01N 30/34 of fluid composition, e.g. gradient G01N30/36 takes precedence

Abstract

Non-interfering, cationic ion pairing reagents and cationic ion pairing reagent systems having volatile combustion products with at most halide, O or S atoms and their combinations as heteroatoms are disclosed that can be used in analytical techniques utilizing element specific detectors. The cationic ion pairing reagents and cationic ion pairing reagent systems have volatile combustion products with at most halide, O or S atoms as heteroatoms. Also, analytical techniques are disclosed using these cationic ion pairing reagents and cationic ion pairing reagent systems.

Claims

1. An cationic ion pairing composition comprising:

at least one cation; and

at least one counterion,

where the cations and counterions have volatile combustion products including O or S or halogen atoms or combinations thereof as their only heteroatoms.

2. The composition of claim 1, wherein the cation has a desired hydrophobicity.

3. The composition of claim 1, wherein:

the cation is selected from the group consisting of oxonium ions, sulfonium ions, sulfoxonium ions and mixtures and combinations thereof; and

the counterion is selected from the group consisting of hydroxide, halide, oxyhalide, sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, carboxylate, phenolate, sulfonate, organosulfate ions and mixtures and combinations thereof.

4. The composition of claim 1, further comprising:

a plurality of counterions,

where each counterion has volatile combustion productions including O or S or halogen atoms or combinations thereof as their only heteroatoms.

5. The composition of claim 1, further comprising:

a plurality of cations,

where each cation has volatile combustion productions including O or S or halogen atoms or combinations thereof as their only heteroatoms.

6. The composition of claim 1, further comprising:

a plurality of cations; and

a plurality of counterions,

where each cation and counterion have volatile combustion productions including O or S or halogen atoms or combinations thereof as their only heteroatoms.

7. The composition of claim 6, wherein the composition covers a desired hydrophobicity range.

8. The composition of claim 6, wherein:

the cations are selected from the group consisting of oxonium ions, sulfonium ions, sulfoxonium ions and mixtures and combinations thereof; and

the counterions are selected from the group consisting of hydroxide, halide, oxyhalide, sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, carboxylate, phenolate, sulfonate, organosulfate ions and mixtures and combinations thereof.

9. A cationic ion pairing composition for use in element-specific detection systems comprising a solution comprising:

a solvent;

a cation selected from the group consisting of oxonium ions, sulfonium ions, sulfoxonium ions and mixtures and combinations thereof; and

a counterion selected from the group consisting of hydroxide, halide, oxyhalide, sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, carboxylate, phenolate, sulfonate, organosulfate ions and mixtures and combinations thereof,

where the cation and counterion and the solvent have volatile combustion products including O or S or halogen atoms or combinations thereof as their only heteroatoms.

10. The composition of claim 9, wherein the cation has a desired hydrophobicity.

11. A cationic ion pairing composition for use in element-specific detection systems comprising:

a solvent;

a plurality of cations selected from the group consisting of oxonium ions, sulfonium ions, sulfoxonium ions and mixtures and combinations thereof; and

a plurality of counterions selected from the group consisting of hydroxide, halide, oxyhalide, sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, carboxylate, phenolate, sulfonate, organosulfate ions and mixtures and combinations thereof,

where the cations and the counterions and the solvent have volatile combustion products including O or S or halogen atoms or combinations thereof as their only heteroatoms.

12. The composition of claim 11, wherein the cations cover a desired hydrophobicity range.

14. The apparatus of claim 13, further comprising:

a transformation zone where at least one sample combustion product is converted into a transformate and a detector capable of detecting at least one transformate.

15. The apparatus of claim 13, wherein the ESD is selected from the group consisting of nitrogen-selective gas-phase chemiluminescence detectors, sulfur-selective gas-phase chemiluminescence detectors, nitrogen-phosphorus thermoionic detectors, atomic emission plasma detectors, inductively-coupled plasma-mass spectrometric (ICP-MS) detectors, and element-specific GC detectors such as nitrogen or phosphorus specific GC detectors.

16. The apparatus of claim 13, wherein the cation has a desired hydrophobicity.

17. The apparatus of claim 13, wherein the cations cover a desired hydrophobicity range.

18. The apparatus of claim 13, wherein:

the cation is selected from the group consisting of oxonium ions, sulfonium ions, sulfoxonium ions and mixtures and combinations thereof; and

the counterion is selected from the group consisting of hydroxide, halide, oxyhalide, sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, carboxylate, phenolate, sulfonate, organosulfate ions and mixtures and combinations thereof.

20. The method of claim 19, further comprising the step of:

converting the at least one analyte combustion product into a transformate; and

detecting the transformate.

21. The method of claim 19, wherein the cation has a desired hydrophobicity.

22. The method of claim 19, wherein the cations cover a desired hydrophobicity range.

23. The method of claim 19, wherein:

the cations are selected from the group consisting of oxonium ions, sulfonium ions, sulfoxonium ions and mixtures and combinations thereof; and

the counterions are selected from the group consisting of hydroxide, halide, oxyhalide, sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, carboxylate, phenolate, sulfonate, organosulfate ions and mixtures and combinations thereof.

25. The method of claim 24, wherein the cation has a desired hydrophobicity.

26. The method of claim 24, wherein the cations cover a desired hydrophobicity range.

27. The method of claim 24, wherein:

the cation is selected from the group consisting of oxonium ions, sulfonium ions, sulfoxonium ions and mixtures and combinations thereof; and

the counterion is selected from the group consisting of hydroxide, halide, oxyhalide, sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, carboxylate, phenolate, sulfonate, organosulfate ions and mixtures and combinations thereof.

13. An apparatus for detecting an analyte comprising:

a separation component where a sample is separated into its components, where the sample comprises at least one analyte and at least one cation and at least one counterion, where the cations and counterions have volatile combustion products including O or S or halogen atoms or combinations thereof as their only heteroatoms and where at least one combustion product of the analyte is detectable;

a combustion zone where the sample is converted to its corresponding combustion products;

a gas-phase or vapor-phase element-specific detector (ESD) capable of detecting the at least one analyte combustion product.

19. A method for analyzing an analyte comprising the steps of:

introducing a sample comprising at least one analyte and at least one cation and at least one counterion into a combustion zone, where the cations and counterions have volatile combustion products including O or S or halogen atoms or combinations thereof as their only heteroatoms;

converting the sample, in the combustion zone, into its corresponding volatile combustion products including at least one analyte combustion product;

measuring the at least one analyte combustion product with a gas-phase or vapor-phase element-specific detector to produce a detector signal; and

determinating an analyte concentration in the sample from the detector signal.

24. A method for forming an cationic ion pairing reagent in situ comprising the steps of:

dissolving a base form of a cation in a solvent to form a solution, where the base form of the cation has volatile combustion products including O or S or halogen atoms or mixtures and combinations thereof as their only heteroatoms;

adding an amount of an acid form of a counterion to the solution, where the acid form of the counterion has volatile combustion products including O or S or halogen atoms or mixtures and combinations thereof as their only heteroatoms, and where the amount is sufficient to convert substantially all of the base form of the cation to its corresponding cation to form an in situ formed cationic ion pairing reagent; and

adding a sample comprising at least one analyte to the solution containing the in situ formed cationic ion pairing reagent.