Composite scaffold with post anchor for the repair and regeneration of tissue
First Claim
1. A prosthetic implant, comprising:
- a tissue scaffold;
a fixation device with a scaffold support and an anchoring post, said anchoring post extending from a surface of said scaffold support at a selected angle, said anchoring post insertable into a receptacle formed in tissue, said scaffold support embedded within said scaffold.
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Accused Products
Abstract
A prosthetic implant having a tissue scaffold and a fixation device with a scaffold support and an anchoring post. The anchoring post extends from a surface of the scaffold support at a selected angle with the scaffold support embedded within the scaffold. The scaffold has a porous ceramic phase and a porous polymer phase. The polymer is foamed while in solution that is infused in the pores of the ceramic to create a interphase junction of interlocked porous materials and embedding the scaffold support portion of the fixation device. The preferred method for foaming is by lyophilization. The scaffold may be infused or coated with a variety of bioactive materials to induce ingrowth or to release a medicament. The mutilayered porous scaffold can mimic the morphology of an injured tissue junction with a gradient morphology and cell composition.
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Citations
24 Claims
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1. A prosthetic implant, comprising:
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a tissue scaffold;
a fixation device with a scaffold support and an anchoring post, said anchoring post extending from a surface of said scaffold support at a selected angle, said anchoring post insertable into a receptacle formed in tissue, said scaffold support embedded within said scaffold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for making a prosthetic implant having a tissue scaffold and an embedded fixation device with a scaffold support and an anchoring post, comprising the steps of:
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a) providing a porous ceramic body with a hole extending therethrough;
b) providing a polymer solution;
c) inserting the anchoring post of the fixation device through the hole in the ceramic body such that the scaffold support contacts the ceramic body forming a first subassembly;
d) placing the support scaffold and the ceramic body of the subassembly in contact with the polymer solution;
e) permitting the polymer solution to at least partially infuse into pores in the ceramic body;
f) foaming the polymer solution to produce a polymer foam, the polymer foam interlocking with the ceramic body where the polymer solution was permitted to infuse into the ceramic body and embedding the scaffold support within the resulting conjoined composite. - View Dependent Claims (23, 24)
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Specification