Microdialysis probes and methods of use
First Claim
1. A microdialysis probe comprising:
- a membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said membrane portion is disposed on said distal end of said outer tube;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, and wherein said inner tube is arranged within said outer tube;
and a guiding means located on said probe in a known spatial relationship with said membrane portion.
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Accused Products
Abstract
The subject invention pertains to novel microdialysis probes having highly advantageous structural features, particularly for clinical applications. A microdialysis probe of the subject invention can be introduced into a biological tissue using insertion means such that the insertion means can the be completely dissociated from the biological tissue and the microdialysis probe. The microdialysis probes of the subject invention can further include guiding means composed of imageable material that may be used to guide the microdialysis probes to a target tissue using the appropriate sensing equipment. A further aspect of the subject invention relates to methods of using novel microdialysis probes to assess the presence or absence of a substance within biological tissue. The subject invention further relates to methods of using novel microdialysis probes to deliver a substance within biological tissue.
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Citations
84 Claims
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1. A microdialysis probe comprising:
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a membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said membrane portion is disposed on said distal end of said outer tube;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, and wherein said inner tube is arranged within said outer tube;
and a guiding means located on said probe in a known spatial relationship with said membrane portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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53. A microdialysis probe comprising:
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a membrane portion;
an outer tube, wherein said outer tube has a proximal end, a distal end, an inner surface, and an outer surface, wherein said distal end of said outer tube is closed, and wherein said outer surface of said outer tube defines an aperture exposing said membrane portion;
an inner tube, wherein said inner tube has a proximal end, a distal end, an inner surface, and an outer surface, and wherein said inner tube is arranged within said outer tube;
and a guiding means located on said probe in a known spatial relationship with said membrane portion.
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54. A microdialysis probe comprising:
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a membrane portion;
an outer tube, wherein said outer tube has a proximal end and a distal end, and wherein said membrane portion is disposed on said distal end of said outer tube; and
an inner tube, wherein said inner tube is arranged within said outer tube, and wherein said inner tube comprises an imageable material. - View Dependent Claims (55, 56, 57, 58, 59, 60)
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61. A microdialysis system comprising:
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a microdialysis probe comprising a membrane portion, an outer tube, wherein said outer tube has a proximal end and a distal end, wherein said membrane portion is disposed on said distal end of said outer tube, and an inner tube arranged within said outer tube, wherein said inner tube has an inner diameter and an outer diameter; and
means for inserting said microdialysis probe into tissue, wherein said insertion means has a lumen with an inner diameter, and wherein said microdialysis probe has an outer diameter smaller than said inner diameter of said lumen of said insertion means such that said microdialysis probe can be inserted completely into said lumen of said insertion means. - View Dependent Claims (62, 63, 64, 65, 66, 67, 69, 70)
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68. A microdialysis system comprising:
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a microdialysis probe comprising a membrane portion, a compressible outer tube, wherein said compressible outer tube has a compressed state and an uncompressed state, wherein said outer tube has a proximal end and a distal end, wherein said membrane portion is disposed on said distal end of said outer tube, and an inner tube, wherein said inner tube is arranged within said outer tube; and
means for inserting said microdialysis probe into tissue, wherein said insertion means has a lumen with an inner diameter, and wherein said outer tube has an outer diameter that is larger than said inner diameter of said lumen of said insertion means when said outer tube is in said uncompressed state, and wherein said outer diameter of said outer tube is smaller than said inner diameter of said lumen of said insertion means when said outer tube is in said compressed state.
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71. A method for introducing a microdialysis probe into a medium comprising:
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providing a microdialysis probe, insertion means, and puncture means, wherein the insertion means has a proximal end, a distal end, and a lumen having an inner diameter, and wherein the puncture means has a proximal end and a distal end;
inserting the puncture means into the lumen of the insertion means such that the distal end of the puncture means extends outside of the distal end of the insertion means;
inserting the puncture means and the insertion means into the medium;
withdrawing the puncture means from the lumen of the insertion means, leaving the insertion means within the medium;
inserting the microdialysis probe into the lumen of the insertion means; and
withdrawing the insertion means from the medium and completely over and off of the microdialysis probe, thereby leaving the microdialysis probe within the medium. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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Specification