Non-invasive method and apparatus for tissue detection

• US 20030009111A1
• Filed: 06/13/2002
• Published: 01/09/2003
• Est. Priority Date: 06/13/2001
• Status: Abandoned Application

• Current Assignee: CKM Diagnostics, Inc.
• Original Assignee: CKM Diagnostics, Inc.
• Inventors: Cory, Joan M., Cory, Philip C.
• Application Number:
  US10/170,194
• Publication Number:
  US 20030009111A1
• Time in Patent Office: Days
• US Class Current: 600/547
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography

Abstract

An apparatus and method for non-invasively determining tissue structure by applying a periodic waveform to an external or internal body part. A microprocessor provides instructions to a waveform generator to generate a plurality of different periodic waveforms to at least one sampling electrode electrically connected to at least on return electrode through the tissue structure. The impedance of the tissue structures are selectively determined for each generated waveform. After determining a plurality of impedance measurements various calculations are performed, including determining a ratio of impedance change and the applied current change. The apparatus may apply the same waveform to all sampling electrodes simultaneously, or apply the waveform to a few as one sampling electrode at a time. The apparatus may also simultaneously apply a plurality of waveforms to a plurality of electrodes to maintain the same current waveform on each sampling electrode.

Claims

1. An apparatus for detecting tissue structures comprising:

a microprocessor;

a waveform generator operable to generate a plurality of different periodic waveforms in response to instructions received from the microprocessor;

at least one sampling electrode operable to receive a waveform from the waveform generator and to apply the received waveform to a tissue of the subject as an applied waveform;

at least one return electrode operable to receive the applied waveform from the tissue of the subject and providing the applied waveform to the microprocessor, thereby completing an electrical circuit which includes the tissue of the subject as a component,

wherein the microprocessor receives information indicative of characteristics of the applied waveform and calculates a non-linear electrical characteristic of the tissue of the test subject.

2. The apparatus of claim 1, wherein the non-linear characteristic which is calculated is the impedance of the tissue.

3. The apparatus of claim 2, wherein the microprocessor is operable to:

instruct the waveform generator to generate a plurality of different waveforms to be applied to the tissue, to selectively calculate the impedance of the tissue for each generated waveform of the plurality of different waveforms, and to perform mathematical calculations selectively using characteristics of the plurality of waveforms and the selectively calculated impedances of the tissue.

4. The apparatus of claim 3, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

5. The apparatus of claim 1, wherein the at least one sampling electrode comprises a plurality of sampling electrodes and wherein the apparatus further comprises a switching device operable to receive instructions from the microprocessor to provide a waveform to any sampling electrode of the plurality of sampling electrodes.

6. The apparatus of claim 5, wherein the switching device is operable to simultaneously provide a single waveform to more than one sampling electrode.

7. The apparatus of claim 5, wherein the switching device is operable to simultaneously provide a plurality of waveforms to more than one sampling electrode in a manner which provides the same current waveform to each of the sampling electrodes of the more than one sampling electrode.

8. The apparatus of claim 5, wherein the non-linear characteristic which is calculated is the impedance of the tissue.

9. The apparatus of claim 8, wherein the microprocessor is operable to:

instruct the waveform generator to generate a plurality of different waveforms to be applied to the tissue, to selectively calculate the impedance of the tissue for each generated waveform of the plurality of different waveforms, and to perform mathematical calculations selectively using characteristics of the plurality of waveforms and the selectively calculated impedances of the tissue.

10. The apparatus of claim 9, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

11. The apparatus of claim 1, wherein the at least one return electrode comprises a plurality of return electrodes and wherein the apparatus further comprises a return switching device operable to receive instructions from the microprocessor to select any return electrode of the plurality of return electrodes to thereby complete an electrical circuit between the at least one sampling electrode and the selected return electrode.

12. The apparatus of claim 1, wherein the at least one sampling electrode comprises a plurality of sampling electrodes and wherein the apparatus further comprises a switching device operable to receive instructions from the microprocessor to provide a waveform to any sampling electrode of the plurality of sampling electrodes, and

wherein the at least one return electrode comprises a plurality of return electrodes and wherein the apparatus further comprises a return switching device operable to receive instructions from the microprocessor to select any return electrode of the plurality of return electrodes to thereby complete an electrical circuit between the at least one sampling electrode and the selected return electrode.

13. The apparatus of claim 1, wherein the non-linear characteristic which is calculated is the reactance of the tissue.

14. The apparatus of claim 1, further comprising a display, and wherein the microprocessor generates a three dimensional image of the tissue and the display is operable to display the three dimensional image.

16. The method of claim 15, wherein the non-linear characteristic which is calculated is the impedance of the tissue.

17. The method of claim 15, further comprising the steps of:

generating a new periodic waveform which is different from a previous periodic waveform,

providing the new periodic waveform to the tissue of a subject through the sampling electrode as another applied waveform;

receiving the another applied waveform from the tissue of the subject through the return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of characteristics of the another applied waveform; and

recalculating a non-linear electrical characteristic of the tissue of the test subject associated with the another applied waveform.

18. The method of claim 17, wherein the non-linear electrical characteristic which is calculated is the impedance of the tissue, and the recalculated non-linear electrical characteristic is the impedance of the tissue, further comprising the step of

performing mathematical calculations selectively using characteristics of the another applied waveform and characteristics of the applied waveform and the calculated impedance of the tissue and the recalculated impedance of the tissue.

19. The method of claim 18, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

20. The method of claim 15, wherein the at least one sampling electrode comprises a plurality of sampling electrodes, and wherein the method further comprises the step of:

simultaneously providing a single waveform to more than one sampling electrode.

21. The method of claim 20, further comprising the steps of:

generating a new periodic waveform which is different from a previous periodic waveform,

providing the new periodic waveform to the tissue of a subject through the sampling electrode as another applied waveform;

receiving the another applied waveform from the tissue of the subject through the return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of characteristics the another applied waveform; and

recalculating a non-linear electrical characteristic of the tissue of the test subject associated with the another applied waveform.

22. The method of claim 21, wherein the non-linear electrical characteristic which is calculated is the impedance of the tissue, and the recalculated non-linear electrical characteristic is the impedance of the tissue, further comprising the step of

performing mathematical calculations selectively using characteristics of the another applied waveform and characteristics of the applied waveform and the calculated impedance of the tissue and the recalculated impedance of the tissue.

23. The method of claim 22, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

24. The method of claim 15, wherein the at least one sampling electrode comprises a plurality of sampling electrodes, and wherein the method further comprises the step of:

simultaneously providing a plurality of waveforms to more than one sampling electrode in a manner which provides the same current waveform to each of the sampling electrodes of the more than one sampling electrode.

25. The method of claim 24, further comprising the steps of:

generating a new periodic waveform which is different from a previous periodic waveform,

providing the new periodic waveform to the tissue of a subject through the sampling electrode as another applied waveform;

receiving the another applied waveform from the tissue of the subject through the return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of the voltage and current of the another applied waveform; and

recalculating a non-linear electrical characteristic of the tissue of the test subject associated with the another applied waveform.

26. The method of claim 25, wherein the non-linear electrical characteristic which is calculated is the impedance of the tissue, and the recalculated non-linear electrical characteristic is the impedance of the tissue, further comprising the step of

performing mathematical calculations selectively using characteristics of the another applied waveform and characteristics of the applied waveform and the calculated impedance of the tissue and the recalculated impedance of the tissue.

27. The method of claim 26, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

28. The method of claim 15, wherein the at least one return electrode comprises a plurality of return electrodes and wherein the method further comprises the step of:

selecting at least one return electrode of the plurality of return electrodes to thereby complete an electrical circuit between the at least one sampling electrode and the at least one selected return electrode.

29. The method of claim 15, wherein the at least one sampling electrode comprises a plurality of sampling electrodes and the at least one return electrode comprises a plurality of return electrodes, and wherein the method further comprises the steps of:

selecting at least one sampling electrode through which the periodic waveform is applied to the tissue of a subject as an applied waveform;

selecting at least one return electrode of the plurality of return electrodes to thereby complete an electrical circuit between the at least one sampling electrode and the at least one selected return electrode.

30. The method of claim 15, wherein the non-linear characteristic which is calculated is the reactance of the tissue.

31. The method of claim 15, further comprising the steps of:

generating a three dimensional image display of the tissue; and

displaying the three dimensional image.

15. A method of detecting tissue structures comprising the steps of:

generating a periodic waveform;

providing the periodic waveform to tissue of a subject through at least one sampling electrode as an applied waveform;

receiving the applied waveform from the tissue of the subject through at least one return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of the characteristic of the applied waveform; and

calculating a non-linear electrical characteristic of the tissue of the test subject associated with the applied waveform.

32. A computer readable medium carrying instructions to cause a computer to institute the performance of a method, the method comprising the steps of:

generating a periodic waveform;

providing the periodic waveform to tissue of a subject through at least one sampling electrode as an applied waveform;

receiving the applied waveform from the tissue of the subject through at least one return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of characteristics of the applied waveform; and

calculating a non-linear electrical characteristic of the tissue of the test subject associated with the applied waveform.

33. The computer readable medium of claim 32, wherein the non-linear characteristic which is calculated is the impedance of the tissue.

34. The computer readable medium of claim 32, further containing instructions to cause a computer to institute performance of a method further comprising the steps of:

generating a new periodic waveform which is different from a previous periodic waveform,

providing the new periodic waveform to the tissue of a subject through the sampling electrode as another applied waveform;

receiving the another applied waveform from the tissue of the subject through the return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of the voltage and current of the another applied waveform; and

recalculating a non-linear electrical characteristic of the tissue of the test subject associated with the another applied waveform.

35. The computer readable medium of claim 32, wherein the non-linear electrical characteristic which is calculated is the impedance of the tissue, and the recalculated non-linear electrical characteristic is the impedance of the tissue, the computer readable medium further containing instructions to cause a computer to institute performance of a method further comprising the steps of:

performing mathematical calculations selectively using characteristics of the another applied waveform and characteristics of the applied waveform and the calculated impedance of the tissue and the recalculated impedance of the tissue.

36. The computer readable medium of claim 35, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

37. The computer readable medium of claim 32, wherein the at least one sampling electrode comprises a plurality of sampling electrodes, and wherein the computer readable medium further contains instructions to cause a computer to perform a method further comprising the step of:

simultaneously providing a single waveform to more than one sampling electrode.

38. The computer readable medium of claim 37, wherein the computer readable medium further contains instructions to cause a computer to institute performance of a method further comprising the steps of:

generating a new periodic waveform which is different from a previous periodic waveform,

providing the new periodic waveform to the tissue of a subject through the sampling electrode as another applied waveform;

receiving the another applied waveform from the tissue of the subject through the return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of the voltage and current of the another applied waveform; and

recalculating a non-linear electrical characteristic of the tissue of the test subject associated with the another applied waveform.

39. The computer readable medium of claim 38, wherein the non-linear electrical characteristic which is calculated is the impedance of the tissue, and the recalculated non-linear electrical characteristic is the impedance of the tissue, the computer readable medium further containing instructions to cause a computer to institute performance of a method further comprising the steps of:

performing mathematical calculations selectively using characteristics of the another applied waveform and characteristics of the applied waveform and the calculated impedance of the tissue and the recalculated impedance of the tissue.

40. The computer readable medium of claim 39, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

41. The computer readable medium of claim 32, wherein the at least one sampling electrode comprises a plurality of sampling electrodes, and wherein the computer readable medium further contains instructions to cause a computer to institute performance of a method further comprising the steps of:

simultaneously providing a plurality of waveforms to more than one sampling electrode in a manner which provides the same current waveform to each of the sampling electrodes of the more than one sampling electrode.

42. The computer readable medium of claim 41, wherein the computer readable medium further contains instructions to cause a computer to institute performance of a method further comprising the steps of:

generating a new periodic waveform which is different from a previous periodic waveform,

providing the new periodic waveform to the tissue of a subject through the sampling electrode as another applied waveform;

receiving the another applied waveform from the tissue of the subject through the return electrode, thereby completing an electrical circuit which includes the tissue of the subject as a component,

receiving information indicative of the voltage and current of the another applied waveform; and

recalculating a non-linear electrical characteristic of the tissue of the test subject associated with the another applied waveform.

43. The computer readable medium of claim 42, wherein the non-linear electrical characteristic which is calculated is the impedance of the tissue, and the recalculated non-linear electrical characteristic is the impedance of the tissue, the computer readable medium further containing instructions to cause a computer to institute performance of a method further comprising the steps of:

performing mathematical calculations selectively using characteristics of the another applied waveform and characteristics of the applied waveform and the calculated impedance of the tissue and the recalculated impedance of the tissue.

44. The computer readable medium of claim 43, wherein the mathematical calculation that is performed is a determination of a ratio of a change in impedance and a change in applied current.

45. The computer readable medium of claim 32, wherein the at least one return electrode comprises a plurality of return electrodes and wherein the computer readable medium further contains instructions to cause a computer to institute performance of a method further comprising the step of:

selecting at least one return electrode of the plurality of return electrodes to thereby complete an electrical circuit between the at least one sampling electrode and the at least one selected return electrode.

46. The computer readable medium of claim 32, wherein the at least one sampling electrode comprises a plurality of sampling electrodes and the at least one return electrode comprises a plurality of return electrodes, and wherein the computer readable medium further contains instructions to cause a computer to institute performance of a method further comprising the steps of:

selecting at least one sampling electrode through which the periodic waveform is applied to the tissue of a subject as an applied waveform;

selecting at least one return electrode of the plurality of return electrodes to thereby complete an electrical circuit between the at least one sampling electrode and the at least one selected return electrode.

47. The computer readable medium of claim 32, wherein the non-linear characteristic which is calculated is the reactance of the tissue.

48. The computer readable medium of claim 47, wherein the computer readable medium further contains instructions to cause a computer to institute performance of a method further comprising the steps of:

generating a three dimensional image display of the tissue; and

displaying the three dimensional image.