Method and apparatus for nullifying the imposed work of breathing

• US 20030010339A1
• Filed: 09/03/2002
• Published: 01/16/2003
• Est. Priority Date: 02/03/1999
• Status: Active Grant

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida (State University System of Florida)
• Inventors: Banner, Michael Joseph, Blanch, Paul Bradford
• Granted Patent: US 6,820,618 B2
• Time in Patent Office: Days
• US Class Current: 128/204.18
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/003 with a flowmeter
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/46 Resistance or compliance of the lungs

Abstract

A method and corresponding medical ventilator for nullifying the work of breathing imposed by the ventilation breathing apparatus during ventilation support of a patient having a source of breathing gas, a pressure sensor, a microprocessor, at least one actuator of a pneumatic system, and driver circuits. The medical ventilator is in fluid communication with the source of breathing and an endotracheal tube which is in fluid communication with the lungs of the patient. At least one driver circuit adjusts at least one actuator to change the supply of the breathing gas. The pressure sensor measures the pressure of the gas proximate the distal end of the endotracheal tube and generates an output based on the sensed pressure. The microprocessor controls the supply of the breathing gas exiting the pneumatic system of the ventilator and is electrically coupled to the output of the pressure sensor. The microprocessor compares the output of the pressure sensor to a predetermined baseline pressure that is greater than zero and, as a result, adjusts the actuator so that the pressure of the gas proximate the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

Claims

1. A method of controlling a medical ventilator on demand during the ventilation of a patient for nullifying the imposed work of breathing during an inhalation effort by the patient, the medical ventilator in fluid communication with a source of breathing gas and with a functionally open gas ventilator flow conduit having an endotracheal tube in fluid communication with the patient, the endotracheal tube having a distal end which is adapted for disposition in the patient'"'"'s trachea, the method comprising the steps of:

a) selecting a predetermined baseline pressure that is at least zero;

b) delivering a predetermined supply of the breathing gas from the ventilator based on a preselected ventilation mode into the endotracheal tube and thence into the patient at the initiation of the inhalation effort;

c) sensing the pressure of the breathing gas proximate the distal end of the endotracheal tube;

d) monitoring the pressure of the breathing gas;

e) automatically and proportionally controlling the supply of breathing gas delivered by the ventilator to substantially maintain the pressure of the breathing gas proximate the distal end of the endotracheal tube at the predetermined baseline pressure throughout the inhalation effort.

2. The method of claim 1, wherein the step of monitoring comprises determining when the pressure of the breathing gas proximate the distal end of the endotracheal tube drops below the value of the predetermined baseline pressure.

3. The method of claim 2, wherein the step of controlling comprises regulating the supply of breathing gas delivered by the medical ventilator when it is determined that the pressure of the breathing gas proximate the distal end of the endotracheal tube is less than the predetermined baseline pressure.

4. The method of claim 3, wherein the step of controlling further comprises restoring the breathing gas supplied by the medical ventilator to the predetermined baseline pressure prior to the next inhalation effort of the patient.

5. The method of claim 3, wherein the regulating step comprises controlling the medical ventilator so as to increase the supply of the breathing gas delivered by the medical ventilator when it is determined that the pressure of the breathing gas proximate the distal end of the endotracheal tube is less than the predetermined baseline pressure so that the pressure of the breathing gas proximate the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

6. The method of claim 4, wherein the restoring step comprises the step of controlling the medical ventilator so as to decrease the supply of the breathing gas delivered by the ventilator when it is determined that the pressure of the breathing gas proximate the distal end of the endotracheal tube is greater than the predetermined baseline pressure.

7. The method of claim 1, wherein the step of sensing the pressure of the breathing gas is performed in a flow path of the gas within the endotracheal tube.

8. The method of claim 1, further comprising the step of determining a patient physiologic work of breathing.

9. The method of claim 8, wherein the step of determining a patient physiologic work of breathing comprises the steps of:

a) sensing the volume of the breathing gas in the ventilator flow conduit; and

b) determining the patient physiologic work of breathing from the sensed pressure and the sensed volume of the breathing gas in the ventilator flow conduit.

10. The method of claim 8, further comprising the step of displaying the patient physiologic work of breathing.

11. The method of claim 9, wherein the step of sensing the volume of the gas is performed in a flow path of the gas within the ventilator conduit.

13. The medical ventilator of claim 12, wherein the processor detects when the pressure of the gas within the endotracheal tube drops below the predetermined baseline pressure and generates a response signal thereof.

14. The medical ventilator of claim 13, wherein the actuator is responsive to the response signal to increase the supply of the breathing gas provided by the medical ventilator so that the pressure of the breathing gas proximate the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

15. The medical ventilator of claim 13, wherein the processor detects when the pressure of the breathing gas within the endotracheal tube exceeds the predetermined baseline pressure and generates a termination signal thereof.

16. The medical ventilator of claim 15, wherein the actuator is responsive to the termination signal to decrease the supply of the breathing gas provided by the ventilator so that the pressure of the breathing gas at the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

17. The medical ventilator of claim 12, wherein the actuator regulates a pressure, a flow rate, or a combination of both to regulate the supply of the breathing gas provided by the ventilator to the patient.

18. The medical ventilator of claim 12, wherein the pressure sensor comprises an analog pressure sensor.

19. The medical ventilator of claim 18, further comprises a digitizer which receives the pressure signal from the analog pressure sensor and converts the pressure signal into a digitized pressure signal which is received by the processor.

12. A medical ventilator for providing breath support to a patient during a medical procedure, the medical ventilator suitable for connection to a source of one or more breathing gases, and to a ventilator flow conduit having an endotracheal tube, the endotracheal tube having a distal end adapted for positioning within the patient'"'"'s trachea, the medical ventilator comprising:

a) a pressure sensor disposed in a flow path of the breathing gas within the endotracheal tube which measures the pressure of the gas proximate the pressure sensor and which provides a pressure signal representative thereof, wherein the pressure sensor is located proximate the distal end of the endotracheal tube;

b) a processor having a program for delivering a supply of the breathing gas from the ventilator based on a preselected ventilation mode at the initiation of an inhalation effort by the patient, the processor responsive to the gas pressure signal generated by the pressure sensor and having a program for automatically and proportionally controlling a supply of the breathing gas delivered thereto the endotracheal tube to substantially maintain the pressure of the breathing gas proximate the distal end of the endotracheal tube at a predetermined baseline pressure that is at least zero throughout the inhalation effort of the patient so that imposed work of breathing is nullified during the inhalation effort; and

c) at least one actuator, responsive to the processor, to regulate the supply of the breathing gas provided by the ventilator to the patient.

20. A medical ventilator for nullifying the imposed work of breathing during an inhalation effort of a patient, the medical ventilator in fluid communication with a source of breathing gas and with a functionally open gas ventilator flow conduit having an endotracheal tube, the endotracheal tube having a distal end adapted for disposition within the patient'"'"'s trachea, the medical ventilator comprising:

a) pressure sensing means disposed within the endotracheal tube for sensing the pressure of the gas proximate the distal end of the endotracheal tube;

b) monitoring means connected to the pressure sensing means for monitoring the pressure of the gas proximate the distal end of the endotracheal tube;

c) gas delivery means for providing a supply of breathing gas to the ventilator flow conduit; and

d) a regulating means electrically connected to the monitoring means and the gas delivery means, the regulating means delivering a predetermined supply of the breathing gas from the ventilator based on a preselected ventilation mode into the endotracheal tube and thence into the patient at the initiation of the inhalation effort, the regulating means, responsive to the monitoring means, for automatically and proportionally regulating the supply of the breathing gas provided to the patient by the gas delivery means so that the pressure of the breathing gas proximate the distal end of the endotracheal tube is maintained at a predetermined baseline pressure that is at least zero throughout the inhalation effort.

21. The medical ventilator of claim 20, wherein the monitoring means detects when the pressure of the breathing gas proximate the distal end of the endotracheal tube drops below the predetermined baseline pressure during the inhalation effort of the patient and generates a response signal thereof.

22. The medical ventilator of claim 21, wherein the regulating means is responsive to the response signal to increase the supply of the breathing gas delivered by the medical ventilator so that the pressure of the breathing gas proximate the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

23. The medical ventilator of claim 20, wherein the monitoring means detects when the pressure of the breathing gas proximate the distal end of the endotracheal tube exceeds the predetermined baseline pressure and generates a termination signal thereof.

24. The medical ventilator of claim 23, wherein the regulating means is responsive to the termination signal to decrease the supply of the breathing gas delivered by the medical ventilator so that the pressure of the breathing gas at the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

25. The medical ventilator of claim 20, wherein the pressure sensing means is disposed in a flow path of the breathing gas within the endotracheal tube.

26. The medical ventilator of claim 25, wherein the pressure sensing means for sensing the pressure of the breathing gas is located proximate the distal end of the endotracheal tube.

27. The medical ventilator of claim 20, wherein the gas delivery means comprises a pneumatic system having at least one electrically coupled actuator, in fluid communication with the gas source for providing the supply of the breathing gas upon command.

28. The medical ventilator of claim 27, wherein the actuator regulates a pressure, a flow rate, or a combination of both to regulate the supply of the breathing gas provided by the ventilator to the patient.

29. The medical ventilator of claim 27, wherein the regulating means comprises at least one driver circuit electrically coupled to the monitoring means and to each actuator, wherein the driver circuit adjusts the actuator based on electrical signals received from the monitoring means, thereby regulating the supply of the breathing gas provided by the gas delivery means.

30. The medical ventilator of claim 20, wherein the monitoring means comprises a microprocessor having a memory means for storing signal data.

31. A respiratory support system for a patient, comprising:

a. an endotracheal tube, the endotracheal tube having a distal end adapted for positioning within the patient'"'"'s trachea;

b. a pressure sensor disposed in a flow path of the breathing gas within the endotracheal tube which measures the pressure of the gas proximate the pressure sensor and which provides a pressure signal representative thereof, wherein the pressure sensor is located proximate the distal end of the endotracheal tube;

c. a medical ventilator for providing breath support to the patient, the medical ventilator adapted for connection to a source of one or more breathing gases and to the endotracheal tube, the medical ventilator having a processor responsive to the gas pressure signal generated by the pressure sensor and having at least one actuator, responsive to the processor, to regulate a supply of the breathing gas provided by the ventilator to the patient, wherein the processor has a program for delivering the supply of the breathing gas to the patient at the initiation of an inhalation effort based on a preselected ventilation mode and a program for automatically and proportionally controlling the supply of the breathing gas delivered thereto the endotracheal tube to substantially maintain the pressure of the breathing gas proximate the distal end of the endotracheal tube at a predetermined baseline pressure that is at least zero throughout an inhalation effort of the patient.

32. The respiratory support system of claim 31, wherein the processor detects when the pressure of the gas within the endotracheal tube drops below the predetermined baseline pressure and generates a response signal thereof.

33. The respiratory support system of claim 32, wherein the actuator is responsive to the response signal to increase the supply of the breathing gas provided by the medical ventilator so that the pressure of the breathing gas proximate the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

34. The respiratory support system of claim 32, wherein the processor detects when the pressure of the breathing gas within the endotracheal tube exceeds the predetermined baseline pressure and generates a termination signal thereof.

35. The respiratory support system of claim 34, wherein the actuator is responsive to the termination signal to decrease the supply of the breathing gas provided by the ventilator so that the pressure of the breathing gas at the distal end of the endotracheal tube is maintained at the predetermined baseline pressure.

36. The respiratory support system of claim 31, wherein the actuator regulates a pressure, a flow rate, or a combination of both to regulate the supply of the breathing gas provided by the ventilator to the patient.