Areal implant with x-ray-visible elements

• US 20030010929A1
• Filed: 07/31/2002
• Published: 01/16/2003
• Est. Priority Date: 01/31/2000
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Medical GmbH (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Medical GmbH (Johnson & Johnson)
• Inventors: Schuldt-Hempe, Barbara, Walther, Christoph, Priewe, Jorg
• Application Number:
  US10/182,933
• Publication Number:
  US 20030010929A1
• Time in Patent Office: Days
• US Class Current: 250/443.1
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2002/0068 having a special mesh pattern
• CPC Class Codes: D04B 21/12 characterised by thread material
• CPC Class Codes: D10B 2509/08 Hernia repair mesh

Abstract

An areal implant has a flexible polymer-based basic structure (10) and X-ray-visible elements (12) and is preferably set up as a permanent implant. The X-ray-visible elements can be arranged in an areal pattern in order to be able to judge the position of the implant in the patient at any time by means of an X-ray procedure.

Claims

1. Areal implant with a flexible polymer-based basic structure (10;

20;

31, 32, 33;

40) and with X-ray-visible elements (12;

22;

34;

42), wherein the implant is flexible as a whole.

2. Implant according to claim 1, characterized in that the X-ray-visible elements (12;

22;

34;

42) are arranged in an areal pattern.

3. Implant according to claim 1 or 2, characterized in that the basic structure (10;

20;

31, 32, 33;

40) includes non-resorbable polymer.

4. Implant according to one of claims 1 to 3, characterized in that the basic structure (10;

20;

31, 32, 33;

40) has one of the forms chosen from the following group;

meshes, tapes, foils, perforated foils.

5. Implant according to one of claims 1 to 4, characterized in that the X-ray-visible elements (12;

22;

34;

42) have at least one of the X-ray-visible substances chosen from the following group;

pure zirconium dioxide, stabilized zirconium dioxide, zirconium nitride, zirconium carbide, tantalum, tantalum pentoxide, barium sulphate, silver, silver iodide, gold, platinum, palladium, iridium, copper, ferric oxides, not very magnetic implant steels, non-magnetic implant steels, titanium, alkali iodides, iodated aromatics, iodated aliphatics, iodated oligomers, iodated polymers, alloys of substances thereof capable of being alloyed.

6. Implant according to one of claims 1 to 5, characterized in that at least part of the X-ray-visible elements is formed as pre-shaped bodies (12;

22) of respective length, width and height in the range of 0.1 mm to 50 mm, the pre-shaped bodies (12;

22) being attached to the basic structure (10;

20).

7. Implant according to claim 6, characterized in that at least one pre-shaped body comprises a mixture of at least one X-ray-visible substance with a binding agent, preferably a non- or slowly resorbable polymer and/or a wax.

8. Implant according to claim 6 or 7, characterized in that at least one pre-shaped body (12;

22) has one of the shapes chosen from the following group;

beads, balls, small tubes, rods, small plates, rings, discs, bones, clips.

9. Implant according to one of claims 6 to 8, characterized in that at least one pre-shaped body (22) has a coating and/or outer layer (24) made from non-resorbable material.

10. Implant according to one of claims 6 to 9, characterized in that at least one pre-shaped body (12;

22) is attached to the basic structure or a holding device connected to the basic structure by knotting, compression, welding and/or gluing.

11. Implant according to one of claims 1 to 10, characterized in that at least part of the X-ray-visible elements comprises a polymer tube or a cord which is filled at least partly with particles of a size of at most 2.5 mm made from an X-ray-visible substance.

12. Implant according to claim 11, characterized in that the X-ray-visible substance is additionally fixed in the polymer tube or the cord, preferably by thermal shrinking and/or gluing.

13. Implant according to one of claims 1 to 12, characterized in that at least part of the X-ray-visible elements (34;

42) is designed as polymer, into which an X-ray-visible substance made from particles of a size in the range of 10 nm to 500 μ

m, preferably 10 nm to 100 μ

m, is compounded.

14. Implant according to claim 13, characterized in that the polymer with X-ray-visible substance (34;

42) is present in the implant in at least one of the forms chosen from the following group;

monofilaments, monofilaments reduced along sections, multifilaments, twines, braided threads, cords, foils, films, small film tapes, tapes, such forms which are provided with knots.

15. Implant according to claim 14, characterized in that the basic structure (40) has polymer with X-ray-visible substance (42).

16. Implant according to claim 14 or 15, characterized in that polymer with X-ray-visible substance (34) is attached as additional component to the basic structure (31, 32, 33).

17. Implant according to one of claims 13 to 16, characterized in that the X-ray-visible substance of the polymer comprises zirconium dioxide.

18. Implant according to one of claims 13 to 17, characterized in that the X-ray-visible substance of the polymer comprises barium sulphate and this polymer is additionally coated with a non-resorbable polymer or wax.

19. Implant according to one of claims 1 to 18, characterized in that at least part of the X-ray-visible elements comprises an X-ray-visible metal thread.

20. Implant according to one of claims 1 to 19, characterized in that at least part of the X-ray-visible elements comprises an X-ray-visible symbol, which is preferably provided repeatedly and at equal intervals.

21. Implant according to claim 20, characterized in that the symbol is designed in one of the forms chosen from the following group:

sewn from X-ray-visible threads, stitched from X-ray-visible threads, embossed from X-ray-visible foil, put together from X-ray-visible objects, put together from X-ray-visible powder.

22. Implant according to one of claims 1 to 21, characterized in that the implant contains at least one of the substances chosen from the following group:

polyalkenes, polypropylene, polyethylene, fluorinated polyolefins, polytetrafluoroethylene, polyvinylidenefluoride, polyamides, polyurethanes, polyisoprenes, polystyrenes, polysilicones, polycarbonates, polyaryletherketones, polymethacrylates, polyacrylates, aromatic polyesters, polyimides, copolymers of polymerisable substances thereof.

23. Implant according to one of claims 1 to 22, characterized in that the basic structure has a proportion of resorbable polymer, which preferably contains at least one of the substances chosen from the following group:

polyhydroxy acids, polylactides, polyglycolides, polyhydroxybutyrates, polyhydroxyvaleriates, polycaprolactones, polydioxanones, synthetic and natural oligo- and polyaminoacids, polyphosphazenes, polyanhydrides, polyorthoesters, polyphosphates, polyphosphonates, polyalcohols, polysaccharides, polyethers, resorbable glasses, copolymers of polymerisable substances thereof.

24. Implant according to one of claims 1 to 23, characterized in that the implant is also detectable by means of ultrasound and/or magnetic resonance tomography.