Method for treating pain

• US 20030013689A1
• Filed: 08/15/2002
• Published: 01/16/2003
• Est. Priority Date: 03/25/1996
• Status: Active Grant

• Current Assignee: Daniel E. Womer, David Reed Helton, Harlan E. Shannon, Mary Jeanne Kallman
• Original Assignee: Daniel E. Womer, David Reed Helton, Harlan E. Shannon, Mary Jeanne Kallman
• Inventors: Helton, David Reed, Womer, Daniel E., Kallman, Mary Jeanne, Shannon, Harlan E.
• Granted Patent: US 6,936,601 B2
• Time in Patent Office: Days
• US Class Current: 514/161
• CPC Class Codes: A61K 31/38 having sulfur as a ring hetero atom
• CPC Class Codes: A61K 31/454 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/5513 1,4-Benzodiazepines, e.g. diazepam or clozapine
• CPC Class Codes: A61K 31/554 having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention provides a method for treating pain using an atypical antipsychotic compound.

Claims

1. A composition for treating pain comprising an analgesic dose of an atypical antipsychotic selected from the group consisting of risperidone, clozapine, seroquel, sertindole, ziprasidone, and zotepine or a pharmaceutically acceptable salt or solvate thereof;

and one or more Drug Used in the Treatment of Pain in a weight ratio of atypical antipsychotic to another Drug Used in the Treatment of Pain from about one part atypical antipsychotic to from about one (1) to about one thousand (1000) parts Drug Used in the Treatment of Pain.

2. A composition of claim 1 wherein the another Drug Used in the Treatment of Pain is selected from the group consisting aspirin, ibuprophen, acetaminophen, indomethacin, Tylenol #3, tricyclic antidepressants (for example desipramine, imipramine, amytriptiline, nortriptile), anticonvulsants (for example, carbamazepine, valproate), and serotonin reuptake inhibitors (for example, fluoxetine, paraoxetine, sertraline), mixed serotonin-norepinephrine reuptake inhibitors (for example venlafaxine, duloxetine), serotonin receptor agonists and antagonists, cholinergic (muscarinic and nicotinic) analgesics, adrenergic agents, and neurokinin antagonists.

3. A composition of claim 1 wherein the atypical antipsychotic is risperidone.

4. A composition of claim 2 wherein the Drug Used in the Treatment of Pain is selected from the group consisting of acetaminophen, cholinergic analgesics, and neurokinin anatagonists.

5. A composition of claim 1 wherein the weight ratio of atypical antipsychotic to another Drug Used in the Treatment of Pain is from about one part atypical antipsychotic to from about one (1) part to from about one hundred (100) parts Drug Used in the Treatment of Pain.

6. A composition of claim 5 wherein the Drug used in the Treatment of Pain is selected from the group consisting of acetaminophen, meperidine, alphaprodine hydrochloride, fentanyl, tramadol, ketorolac, allopurinol, methysergide maleate, methotrimeprazine, and indomethacin.

7. A composition of claim 5 wherein the weight ratio of atypical antipsychotic to another Drug Used in the Treatment of Pain is from about one part atypical antipsychotic to from about one (1) part to from about ten (10) parts Drug Used in the Treatment of Pain.

8. A composition of claim 7 wherein the weight ratio of atypical antipsychotic to another Drug Used in the Treatment of Pain is from about one part atypical antipsychotic to from about one (1) part to from about three (3) parts Drug Used in the Treatment of Pain.

9. A composition of claim 8 wherein the Drug Used in the Treatment of Pain is acetaminophen.

10. A composition of claim 1 wherein the atypical antipsychotic is clozapine.

11. A composition of claim 1 wherein the atypical antipsychotic is seroquel.

12. A composition of claim 1 wherein the atypical antipsychotic is sertindole.

13. A composition of claim 1 wherein the atypical antipsychotic is ziprasidone.

14. A composition of claim 1 wherein the atypical antipsychotic is zotepine.

16. A method of claim 15 wherein the Drug Used in the Treatment of Pain is selected from the group consisting of group consisting of acetominophen, indomethacin, Tylenol #3, tricyclic antidepressants (for example desipramine, imipramine, amytriptiline, nortriptile), anticonvulsants (for example, carbamazepine, valproate), and serotonin reuptake inhibitors (for example, fluoxetine, paraoxetine, sertraline), mixed serotonin-norepinephrine reuptake inhibitors (for example venlafaxine, duloxetine), serotonin receptor agonists and antagonists, cholinergic (muscarinic and nicotinic) analgesics, adrenergic agents, and neurokinin antagonists.

17. A method of claim 16 wherein Drug Used in the Treatment of Pain is selected from the group consisting of acetaminophen, meperidine, alphaprodine hydrochloride, fentanyl, tramadol, ketorolac, allopurinol, methysergide maleate, methotrimeprazine, and indomethacin.

19. A method of claim 18 wherein the atypical antipsychotic is Clozapine.

20. A method of claim 18 wherein the atypical antipsychotic is risperidone.

21. A method of claim 18 wherein the atypical antipsychotic is seroquel.

22. A method of claim 18 wherein the atypical antipsychotic is sertindole.

23. A method of claim 18 wherein the atypical antipsychotic is ziprasidone.

24. A method of claim 18 wherein the atypical antipsychotic is zotepine.

25. A method of claim 18 wherein pain is neuropathic pain.

26. A method of claim 18 wherein pain is nociceptive pain.

15. A method for treating pain comprising administering an analgesic dose of a composition comprising an atypical antipsychotic selected from the group consisting of risperidone, clozapine, seroquel, sertindole, ziprasidone, and zotepine or a pharmaceutically acceptable salt or solvate thereof;

and one or more Drug Used in the Treatment of Pain in a weight ratio of atypical antispychotic to Drug Used in the Treatment of Pain of from about one (1) part atypical antipsychotic to from about one (1) part to about one thousand (1000) parts Drug Used in the Treatment of Pain.

18. A method for treating pain in a mammal comprising administering an analgesic dose an atypical antipsychotic selected from the group consisting of risperidone, clozapine, seroquel, sertindole, ziprasidone, and zotepine or a pharmaceutically acceptable salt or solvate thereof;

to a mammal in need of such treatment.