Database organization and searching

• US 20030013951A1
• Filed: 09/21/2001
• Published: 01/16/2003
• Est. Priority Date: 09/21/2000
• Status: Abandoned Application

• Current Assignee: MD On-Line, Inc. (ABILITY Network, Inc.)
• Original Assignee: MD On-Line, Inc. (ABILITY Network, Inc.)
• Inventors: Leventon, Michael, Stefanescu, Dan
• Application Number:
  US09/960,874
• Publication Number:
  US 20030013951A1
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: G06F 16/532 Query formulation, e.g. graphical querying
• CPC Class Codes: G06F 16/5838 using colour
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06T 7/30 Determination of transform parameters for the alignment of images, i.e. image registration
• CPC Class Codes: G16H 30/40 for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

The database organization and searching systems disclosed herein provide techniques for organizing large-scale image data sources such as medical image databases. Database records such as medical images may be pre-processed, such as through registration, segmentation, and extraction of feature vectors, to effectively normalize data among different images. Each image, or a portion thereof, is then labeled according to some observed characteristic or other attribute. A model, such as a linear regression model, may then be trained to associate the feature vectors with the labels. The model is then available for labeling other images. In this manner, search techniques for well-organized or indexed databases may be applied automatically to databases that are not well-organized, but that have the same underlying data type. Data that is organized in this way may also be used to construct diagnostic aids or other tools.

Claims

1. A method comprising:

receiving a plurality of images, each one of the plurality of images including an instance of a human body part obtained through a medical imaging technique;

registering each one of the plurality of images in a non-rigid manner to a coordinate system to superimpose one or more like features within each one of the plurality of images within the coordinate system, thereby obtaining a plurality of registered images;

labeling each one of the plurality of registered images with a label according to an observed characteristic;

obtaining one or more feature vectors from each one of the plurality of registered images; and

training a model to associate the one or more feature vectors with the label.

2. The method of claim 1 further comprising applying the model to generate a label for each one of an additional plurality of images.

3. The method of claim 1 wherein each label is a position of an image on a z-axis perpendicular to an image plane of the image.

4. The method of claim 1 wherein each label is a region of interest.

5. The method of claim 1 wherein each label is at least one of an age, a sex, a diagnosis, a presence of contrast agents, an image type, or a diagnostic significance of a region of interest.

6. The method of claim 1 wherein the model is derived from a statistical learning methodology.

7. The method of claim 1 wherein the model is a linear regression model.

8. The method of claim 1 wherein partial least squares are used to determine one or more coefficients of the model.

9. The method of claim 1 wherein the model includes a weighted norm that is a function of a type of the label, the weighted norm used to estimate new labels with the model, and the type of label including at least one of a pathology, a spatial position, or client data.

10. The method of claim 1 further comprising applying the model to generate labels for a second database of images.

11. The method of claim 1 wherein each one of the plurality of images includes at least one of a magnetic resonance image or a computerized tomography image.

12. The method of claim 1 wherein each one of the plurality of images includes at least one of a head image, a neck image, a spine image, a chest image, or a musculo-skeletal image.

13. The method of claim 1 further comprising:

locating an image database that is accessible through a network, the image database including a second plurality of images;

registering each one of the second plurality of images in a non-rigid manner to a coordinate system to superimpose one or more like features within each one of the second plurality of images within the coordinate system, thereby obtaining a second plurality of registered images;

applying the model to label each one of the second plurality of images; and

searching the image database using the labels to evaluate a similarity of a query to one or more of the second plurality of images.

14. The method of claim 11 further comprising organizing a plurality of databases by locating images, registering images, and labeling images within each one of the plurality of databases, each one of the plurality of databases being labeled with a different model, and searching the plurality of databases using the labels to evaluate a similarity of a query to one or more records in each of the plurality of databases.

17. The computer program product of claim 16 further comprising computer executable code for applying the model to generate a label for each one of an additional plurality of images.

19. The method of claim 16 wherein the header includes a magnetic resonance imaging characteristic.

20. The method of claim 18 wherein the header includes at least one of a contrast agent attribute that indicates a presence or absence of a contrast agent, or a sequence type attribute that indicates a sequence type for the plurality of images, the sequence type being at least one of MRA or T1.

24. The method of claim 1 further comprising using the spatial probability map as a medical diagnostic aid.

15. A system comprising:

receiving means for receiving a plurality of images, each one of the plurality of images including an instance of a human body part obtained through a medical imaging technique;

registering means for registering each one of the plurality of images in a non-rigid manner to a coordinate system to superimpose one or more like features within each one of the plurality of images within the coordinate system, thereby obtaining a plurality of registered images;

labeling means for labeling each one of the plurality of registered images with a label according to an observed characteristic;

obtaining means for obtaining one or more feature vectors from each one of the plurality of registered images; and

training means for training a model to associate the one or more feature vectors with the label.

16. A computer program product comprising:

computer executable code for receiving a plurality of images, each one of the plurality of images including an instance of a human body part obtained through a medical imaging technique;

computer executable code for registering each one of the plurality of images in a non-rigid manner to a coordinate system to superimpose one or more like features within each one of the plurality of images within the coordinate system, thereby obtaining a plurality of registered images;

computer executable code for labeling each one of the plurality of registered images with a label according to an observed characteristic;

computer executable code for obtaining one or more feature vectors from each one of the plurality of registered images; and

computer executable code for training a model to associate the one or more feature vectors with the label.

18. A method comprising:

receiving a plurality of images, each one of the plurality of images including an instance of a human body part obtained through a medical imaging technique;

registering each one of the plurality of images in a non-rigid manner to a coordinate system to superimpose one or more like features within each one of the plurality of images within the coordinate system, thereby obtaining a plurality of registered images;

receiving a header for each one of the plurality of images that includes data associated with the one of the plurality of images;

obtaining one or more feature vectors from each one of the plurality of registered images;

training a model to associate the one or more feature vectors with the header; and

applying the model to identify the presence of any errors in a new header for a new image.

21. A method comprising:

receiving a plurality of images, each one of the plurality of images including an instance of a human body part obtained through a medical imaging technique;

registering each one of the plurality of images in a non-rigid manner to a coordinate system to superimpose one or more like features within each one of the plurality of images within the coordinate system, thereby obtaining a plurality of registered images;

obtaining one or more feature vectors from each one of the plurality of registered images;

associating a pathology with each one of the plurality of images;

training a model to associate the pathology associated with each image with the one or more feature vectors for that image; and

applying the model to identify the presence of the pathology in a new image.

22. The method of claim 21 further comprising obtaining each one of the one or more feature vectors from a region of interest within one of the plurality of images.

23. A method comprising:

receiving a plurality of images, each one of the plurality of images including an instance of a human body part obtained through a medical imaging technique;

registering each one of the plurality of images in a non-rigid manner to a coordinate system to superimpose one or more like features within each one of the plurality of images within the coordinate system, thereby obtaining a plurality of registered images;

identifying one or more regions of interest in each of the plurality of registered images, the regions of interest including a pathology; and

generating a spatial probability map of locations of the pathology from the plurality of registered images and the regions of interest.